PMID- 32630483
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 6
DP  - 2020 Jun 25
TI  - Left Ventricular Geometry and Replacement Fibrosis Detected by cMRI Are 
      Associated with Major Adverse Cardiovascular Events in Nonischemic Dilated 
      Cardiomyopathy.
LID - 10.3390/jcm9061997 [doi]
LID - 1997
AB  - To investigate the relationship between left ventricular (LV) long-axis strain 
      (LAS) and LV sphericity index (LVSI) and outcomes in patients with nonischemic 
      dilated cardiomyopathy (NIDCM) and myocardial replacement fibrosis confirmed by 
      late gadolinium enhancement (LGE) using cardiac magnetic resonance imaging 
      (cMRI), we conducted a prospective study on 178 patients (48 +/- 14.4 years; 25.2% 
      women) with first NIDCM diagnosis. The evaluation protocol included ECG 
      monitoring, echocardiography and cMRI. LAS and LVSI were cMRI-determined. Major 
      adverse cardiovascular events (MACEs) were defined as a composite outcome 
      including heart failure (HF), ventricular arrhythmias (VAs) and sudden cardiac 
      death (SCD). After a median follow-up of 17 months, patients with LGE+ had 
      increased risk of MACEs. Kaplan-Meier curves showed significantly higher rate of 
      MACEs in patients with LGE+ (p < 0.001), increased LVSI (p < 0.01) and decreased 
      LAS (p < 0.001). In Cox analysis, LAS (HR = 1.32, 95%CI (1.54-9.14), p = 0.001), 
      LVSI [HR = 1.17, 95%CI (1.45-7.19), p < 0.01] and LGE+ (HR = 1.77, 95%CI 
      (2.79-12.51), p < 0.0001) were independent predictors for MACEs. In a 4-point 
      risk scoring system based on LV ejection fraction (LVEF) < 30%, LGE+, LAS > -7.8% 
      and LVSI > 0.48%, patients with 3 and 4 points had a significantly higher risk 
      for MACEs. LAS and LVSI are independent predictors of MACEs and provide 
      incremental value beyond LVEF and LGE+ in patients with NIDCM and myocardial 
      fibrosis.
FAU - Cojan-Minzat, Bianca Olivia
AU  - Cojan-Minzat BO
AD  - Department of Internal Medicine, Iuliu Hatieganu University of Medicine and 
      Pharmacy, 400006 Cluj-Napoca, Romania.
AD  - Department of Family Medicine, Iuliu Hatieganu University of Medicine and 
      Pharmacy, 400001 Cluj-Napoca, Romania.
FAU - Zlibut, Alexandru
AU  - Zlibut A
AD  - Department of Internal Medicine, Iuliu Hatieganu University of Medicine and 
      Pharmacy, 400006 Cluj-Napoca, Romania.
FAU - Muresan, Ioana Danuta
AU  - Muresan ID
AD  - Department of Internal Medicine, Iuliu Hatieganu University of Medicine and 
      Pharmacy, 400006 Cluj-Napoca, Romania.
FAU - Cionca, Carmen
AU  - Cionca C
AD  - Department of Radiology, Affidea Hiperdia Diagnostic Imaging Center, 400015 
      Cluj-Napoca, Romania.
FAU - Horvat, Dalma
AU  - Horvat D
AUID- ORCID: 0000-0003-4857-6941
AD  - Department of Internal Medicine, Iuliu Hatieganu University of Medicine and 
      Pharmacy, 400006 Cluj-Napoca, Romania.
FAU - Kiss, Eva
AU  - Kiss E
AD  - Department of Internal Medicine, Iuliu Hatieganu University of Medicine and 
      Pharmacy, 400006 Cluj-Napoca, Romania.
FAU - Revnic, Radu
AU  - Revnic R
AD  - Department of Family Medicine, Iuliu Hatieganu University of Medicine and 
      Pharmacy, 400001 Cluj-Napoca, Romania.
FAU - Florea, Mira
AU  - Florea M
AD  - Department of Family Medicine, Iuliu Hatieganu University of Medicine and 
      Pharmacy, 400001 Cluj-Napoca, Romania.
FAU - Ciortea, Razvan
AU  - Ciortea R
AD  - Department of Internal Medicine, Iuliu Hatieganu University of Medicine and 
      Pharmacy, 400006 Cluj-Napoca, Romania.
AD  - Department of Obstetrics and Gynecology, Emergency County Hospital, 400124 
      Cluj-Napoca, Romania.
FAU - Agoston-Coldea, Lucia
AU  - Agoston-Coldea L
AD  - Department of Internal Medicine, Iuliu Hatieganu University of Medicine and 
      Pharmacy, 400006 Cluj-Napoca, Romania.
AD  - Department of Radiology, Affidea Hiperdia Diagnostic Imaging Center, 400015 
      Cluj-Napoca, Romania.
AD  - 2nd Department of Internal Medicine, Emergency County Hospital, 400006 
      Cluj-Napoca, Romania.
LA  - eng
PT  - Journal Article
DEP - 20200625
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7355464
OTO - NOTNLM
OT  - cardiac magnetic resonance imaging
OT  - late gadolinium enhancement
OT  - left ventricle sphericity index
OT  - long axis strain
OT  - major adverse cardiovascular events
OT  - nonischemic dilated cardiomyopathy
COIS- The authors declare no conflict of interest.
EDAT- 2020/07/08 06:00
MHDA- 2020/07/08 06:01
PMCR- 2020/06/25
CRDT- 2020/07/08 06:00
PHST- 2020/05/07 00:00 [received]
PHST- 2020/06/18 00:00 [revised]
PHST- 2020/06/22 00:00 [accepted]
PHST- 2020/07/08 06:00 [entrez]
PHST- 2020/07/08 06:00 [pubmed]
PHST- 2020/07/08 06:01 [medline]
PHST- 2020/06/25 00:00 [pmc-release]
AID - jcm9061997 [pii]
AID - jcm-09-01997 [pii]
AID - 10.3390/jcm9061997 [doi]
PST - epublish
SO  - J Clin Med. 2020 Jun 25;9(6):1997. doi: 10.3390/jcm9061997.