PMID- 32630731
OWN - NLM
STAT- MEDLINE
DCOM- 20210419
LR  - 20210419
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 10
IP  - 7
DP  - 2020 Jul 2
TI  - Hydrogen Sulfide Alleviates Anxiety, Motor, and Cognitive Dysfunctions in Rats 
      with Maternal Hyperhomocysteinemia via Mitigation of Oxidative Stress.
LID - 10.3390/biom10070995 [doi]
LID - 995
AB  - Hydrogen sulfide (H(2)S) is endogenously produced from sulfur containing amino 
      acids, including homocysteine and exerts neuroprotective effects. An increase of 
      homocysteine during pregnancy impairs fetal growth and development of the 
      offspring due to severe oxidative stress. We analyzed the effects of the H(2)S 
      donor-sodium hydrosulfide (NaHS) administered to female rats with 
      hyperhomocysteinemia (hHcy) on behavioral impairments and levels of oxidative 
      stress of their offspring. Rats born from females fed with control or high 
      methionine diet, with or without H(2)S donor injections were investigated. Rats 
      with maternal hHcy exhibit increased levels of total locomotor activity and 
      anxiety, decreased muscle endurance and motor coordination, abnormalities of fine 
      motor control, as well as reduced spatial memory and learning. Oxidative stress 
      in brain tissues measured by activity of glutathione peroxidases and the level of 
      malondialdehyde was higher in rats with maternal hHcy. Concentrations of H(2)S 
      and the activity and expression of the H(2)S generating enzyme-cystathionine-beta 
      synthase-were lower compared to the control group. Administration of the H(2)S 
      donor to females with hHcy during pregnancy prevented behavioral alterations and 
      oxidative stress of their offspring. The acquisition of behavioral together with 
      biochemical studies will add to our knowledge about homocysteine neurotoxicity 
      and proposes H(2)S as a potential agent for therapy of hHcy associated disorders.
FAU - Yakovleva, Olga
AU  - Yakovleva O
AD  - Department of Human and Animal physiology, Kazan Federal University, 18 
      Kremlevskaya str., 420008 Kazan, Russia.
FAU - Bogatova, Ksenia
AU  - Bogatova K
AD  - Department of Human and Animal physiology, Kazan Federal University, 18 
      Kremlevskaya str., 420008 Kazan, Russia.
FAU - Mukhtarova, Renata
AU  - Mukhtarova R
AD  - Department of Human and Animal physiology, Kazan Federal University, 18 
      Kremlevskaya str., 420008 Kazan, Russia.
FAU - Yakovlev, Aleksey
AU  - Yakovlev A
AD  - Department of Human and Animal physiology, Kazan Federal University, 18 
      Kremlevskaya str., 420008 Kazan, Russia.
FAU - Shakhmatova, Viktoria
AU  - Shakhmatova V
AD  - Department of Human and Animal physiology, Kazan Federal University, 18 
      Kremlevskaya str., 420008 Kazan, Russia.
FAU - Gerasimova, Elena
AU  - Gerasimova E
AD  - Department of Human and Animal physiology, Kazan Federal University, 18 
      Kremlevskaya str., 420008 Kazan, Russia.
FAU - Ziyatdinova, Guzel
AU  - Ziyatdinova G
AUID- ORCID: 0000-0002-8219-2813
AD  - Department of analytical chemistry, Kazan Federal University, 18 Kremlevskaya 
      str., 420008 Kazan, Russia.
FAU - Hermann, Anton
AU  - Hermann A
AD  - Department of Biosciences, University of Salzburg, Salzburg 5020, Austria.
FAU - Sitdikova, Guzel
AU  - Sitdikova G
AUID- ORCID: 0000-0001-5412-2204
AD  - Department of Human and Animal physiology, Kazan Federal University, 18 
      Kremlevskaya str., 420008 Kazan, Russia.
LA  - eng
GR  - numero sign 20-15-00100/Russian Science Foundation/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200702
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 0 (Reactive Oxygen Species)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - EC 4.2.1.22 (Cystathionine beta-Synthase)
RN  - YY9FVM7NSN (Hydrogen Sulfide)
SB  - IM
MH  - Animals
MH  - Anxiety/etiology/metabolism/*prevention & control
MH  - Cognitive Dysfunction/etiology/*prevention & control
MH  - Cystathionine beta-Synthase/metabolism
MH  - Female
MH  - Homocysteine/blood
MH  - Hydrogen Sulfide/*administration & dosage/pharmacology
MH  - Hyperhomocysteinemia/*drug therapy/psychology
MH  - Male
MH  - Oxidative Stress/*drug effects
MH  - Pregnancy
MH  - Pregnancy Complications/*drug therapy/psychology
MH  - Rats
MH  - Reactive Oxygen Species/metabolism
MH  - Treatment Outcome
PMC - PMC7408246
OTO - NOTNLM
OT  - H2S production
OT  - anxiety
OT  - hydrogen sulfide (H2S)
OT  - learning and memory
OT  - locomotor activity
OT  - maternal hyperhomocysteinemia (hHcy)
OT  - motor dysfunction
OT  - oxidative stress
COIS- The authors declare no conflict of interest.
EDAT- 2020/07/08 06:00
MHDA- 2021/04/20 06:00
PMCR- 2020/07/01
CRDT- 2020/07/08 06:00
PHST- 2020/05/25 00:00 [received]
PHST- 2020/06/26 00:00 [revised]
PHST- 2020/06/30 00:00 [accepted]
PHST- 2020/07/08 06:00 [entrez]
PHST- 2020/07/08 06:00 [pubmed]
PHST- 2021/04/20 06:00 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - biom10070995 [pii]
AID - biomolecules-10-00995 [pii]
AID - 10.3390/biom10070995 [doi]
PST - epublish
SO  - Biomolecules. 2020 Jul 2;10(7):995. doi: 10.3390/biom10070995.