PMID- 32631269 OWN - NLM STAT- MEDLINE DCOM- 20210216 LR - 20210216 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 20 IP - 1 DP - 2020 Jul 6 TI - Effects of pre-pregnancy body mass index and gestational weight gain on maternal and infant complications. PG - 390 LID - 10.1186/s12884-020-03071-y [doi] LID - 390 AB - BACKGROUND: The potential effects of pre-pregnancy body mass (BMI) and gestational weight gain (GWG) on pregnancy outcomes remain unclear. Thus, we investigated socio-demographic characteristics that affect pre-pregnancy BMIs and GWG and the effects of pre-pregnancy BMI and GWG on Chinese maternal and infant complications. METHODS: 3172 women were enrolled in the Chinese Pregnant Women Cohort Study-Peking Union Medical College from July 25, 2017 to July 24, 2018, whose babies were delivered before December 31, 2018. Regression analysis was employed to evaluate the socio-demographic characteristics affecting pre-pregnancy BMI and GWG values and their effects on adverse maternal and infant complications. RESULTS: Multivariate logistic regression analysis revealed that age groups < 20 years (OR: 1.97), 25-30 years (OR: 1.66), 30-35 years (OR: 2.24), 35-40 years (OR: 3.90) and >/= 40 years (OR: 3.33) as well as elementary school or education below (OR: 3.53), middle school (OR: 1.53), high school (OR: 1.40), and living in the north (OR: 1.37) were risk factors in maintaining a normal pre-pregnancy BMI. An age range of 30-35 years (OR: 0.76), living in the north (OR: 1.32) and race of ethnic minorities (OR: 1.51) were factors affecting GWG. Overweight (OR: 2.01) and inadequate GWG (OR: 1.60) were risk factors for gestational diabetes mellitus (GDM). Overweight (OR: 2.80) and obesity (OR: 5.42) were risk factors for gestational hypertension (GHp). Overweight (OR: 1.92), obesity (OR: 2.48) and excessive GWG (OR: 1.95) were risk factors for macrosomia. Overweight and excessive GWG were risk factors for a large gestational age (LGA) and inadequate GWG was a risk factor for low birth weights. CONCLUSIONS: Overweight and obesity before pregnancy and an excessive GWG are associated with a greater risk of developing GDM, GHp, macrosomia and LGA. The control of body weight before and during the course of pregnancy is recommended to decrease adverse pregnancy outcomes, especially in pregnant women aged < 20 or > 25 years old educated below university and college levels, for ethnic minorities and those women who live in the north of China. TRIAL REGISTRATION: Registered at Clinical Trials ( NCT03403543 ), September 29, 2017. FAU - Sun, Yin AU - Sun Y AD - Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing, 100730, China. FAU - Shen, Zhongzhou AU - Shen Z AD - Department of Epidemiology and Health Statistics, School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9 Dongdan Santiao, Dongcheng District, Beijing, 100730, China. FAU - Zhan, Yongle AU - Zhan Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9 Dongdan Santiao, Dongcheng District, Beijing, 100730, China. FAU - Wang, Yawen AU - Wang Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9 Dongdan Santiao, Dongcheng District, Beijing, 100730, China. FAU - Ma, Shuai AU - Ma S AD - Department of Epidemiology and Health Statistics, School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9 Dongdan Santiao, Dongcheng District, Beijing, 100730, China. FAU - Zhang, Suhan AU - Zhang S AD - Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing, 100730, China. FAU - Liu, Juntao AU - Liu J AD - Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing, 100730, China. FAU - Wu, Sansan AU - Wu S AD - Department of Epidemiology and Health Statistics, School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9 Dongdan Santiao, Dongcheng District, Beijing, 100730, China. FAU - Feng, Yahui AU - Feng Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9 Dongdan Santiao, Dongcheng District, Beijing, 100730, China. FAU - Chen, Yunli AU - Chen Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9 Dongdan Santiao, Dongcheng District, Beijing, 100730, China. FAU - Cai, Shuya AU - Cai S AD - Department of Epidemiology and Health Statistics, School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9 Dongdan Santiao, Dongcheng District, Beijing, 100730, China. FAU - Shi, Yingjie AU - Shi Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9 Dongdan Santiao, Dongcheng District, Beijing, 100730, China. FAU - Ma, Liangkun AU - Ma L AD - Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing, 100730, China. maliangkun@pumch.cn. FAU - Jiang, Yu AU - Jiang Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9 Dongdan Santiao, Dongcheng District, Beijing, 100730, China. jiangyu@pumc.edu.cn. LA - eng SI - ClinicalTrials.gov/NCT03403543 GR - 2016-I2/Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences/ GR - M-1-008/Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences/ PT - Clinical Trial PT - Journal Article DEP - 20200706 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Adult MH - Birth Weight MH - *Body Mass Index MH - China/epidemiology MH - Cohort Studies MH - Diabetes, Gestational/epidemiology MH - Female MH - Fetal Macrosomia/epidemiology MH - Gestational Age MH - *Gestational Weight Gain MH - Humans MH - Hypertension, Pregnancy-Induced/epidemiology MH - Infant, Newborn MH - Obesity/complications MH - Overweight/complications MH - Pregnancy MH - Pregnancy Complications/*epidemiology MH - Pregnancy Outcome/*epidemiology MH - Risk Factors MH - Socioeconomic Factors MH - Young Adult PMC - PMC7336408 OTO - NOTNLM OT - Chinese pregnant women OT - Cohort study OT - Gestational weight gain OT - Maternal outcomes OT - Neonatal outcomes OT - Pre-pregnancy BMI COIS- The authors declare that they have no conflict of interest. EDAT- 2020/07/08 06:00 MHDA- 2021/02/17 06:00 PMCR- 2020/07/06 CRDT- 2020/07/08 06:00 PHST- 2020/01/22 00:00 [received] PHST- 2020/06/19 00:00 [accepted] PHST- 2020/07/08 06:00 [entrez] PHST- 2020/07/08 06:00 [pubmed] PHST- 2021/02/17 06:00 [medline] PHST- 2020/07/06 00:00 [pmc-release] AID - 10.1186/s12884-020-03071-y [pii] AID - 3071 [pii] AID - 10.1186/s12884-020-03071-y [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2020 Jul 6;20(1):390. doi: 10.1186/s12884-020-03071-y.