PMID- 32633609
OWN - NLM
STAT- MEDLINE
DCOM- 20210419
LR  - 20210419
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 164
IP  - 2
DP  - 2021 Feb
TI  - Pathologic Tumor Size as a Predictor of the Survival Outcomes of Patients With 
      Glottic Carcinoma.
PG  - 353-358
LID - 10.1177/0194599820937296 [doi]
AB  - OBJECTIVES: The purpose of this study was to evaluate the potential predictor of 
      tumor size on rates of overall and disease-free survival (OS and DFS) as 
      determined by postoperative pathologic examination in patients with glottic 
      carcinoma. STUDY DESIGN: Retrospective cohort study. SETTING: Tertiary care 
      university hospital. SUBJECTS AND METHODS: In this study, 1337 consecutive 
      patients with glottic carcinoma who underwent surgical treatment from 2005 to 
      2010 were retrospectively reviewed. The influence of tumor size that was 
      evaluated by tumor area (tumor length x tumor width) on OS and DFS outcomes was 
      assessed by Cox regression analyses. RESULTS: In all, 1303 (97.5%) patients were 
      male, and 34 (2.5%) were female, with a mean +/- SD age of 60.4 +/- 10 years. The 
      10-year OS and DFS rates were 72.9% and 69.9%, respectively. The tumor area 
      cutoff values that best discriminated OS and DFS rates were both 1.80 cm(2). 
      Patients with glottic carcinoma with a larger tumor area had inferior OS and DFS 
      rates. Based on the results of multivariate analyses, tumor area was an 
      independent prognostic factor for rates of OS (hazard ratio, 1.87; 95% CI, 
      1.37-2.56; P < .001) and DFS (hazard ratio, 1.79; 95% CI, 1.34-2.38; P < .001) in 
      patients with glottic carcinoma. CONCLUSIONS: The results of this study indicate 
      that patients with glottic carcinoma with a tumor area >1.8 cm(2) have inferior 
      survival outcomes, and this factor independently predicts survival outcomes in 
      these patients.
FAU - Gong, Hongli
AU  - Gong H
AD  - Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan 
      University, Shanghai, China.
FAU - Zhou, Liang
AU  - Zhou L
AD  - Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan 
      University, Shanghai, China.
FAU - Wu, Haitao
AU  - Wu H
AD  - Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan 
      University, Shanghai, China.
FAU - Tao, Lei
AU  - Tao L
AD  - Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan 
      University, Shanghai, China.
FAU - Zhang, Ming
AU  - Zhang M
AD  - Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan 
      University, Shanghai, China.
FAU - Chen, Xiaoling
AU  - Chen X
AD  - Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan 
      University, Shanghai, China.
FAU - Li, Xiaoming
AU  - Li X
AD  - Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan 
      University, Shanghai, China.
FAU - Li, Cai
AU  - Li C
AD  - Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan 
      University, Shanghai, China.
FAU - Zhou, Jian
AU  - Zhou J
AD  - Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan 
      University, Shanghai, China.
FAU - Wang, Shuyi
AU  - Wang S
AD  - Department of Pathology, Eye, Ear, Nose, and Throat Hospital, Fudan University, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200707
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - China/epidemiology
MH  - Disease-Free Survival
MH  - Female
MH  - Follow-Up Studies
MH  - Glottis/*pathology/surgery
MH  - Humans
MH  - Laryngeal Neoplasms/mortality/*pathology/surgery
MH  - Laryngectomy
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging/*methods
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate/trends
OTO - NOTNLM
OT  - glottic carcinoma
OT  - prognosis
OT  - surgery
OT  - survival
OT  - tumor size
EDAT- 2020/07/08 06:00
MHDA- 2021/04/20 06:00
CRDT- 2020/07/08 06:00
PHST- 2020/07/08 06:00 [pubmed]
PHST- 2021/04/20 06:00 [medline]
PHST- 2020/07/08 06:00 [entrez]
AID - 10.1177/0194599820937296 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2021 Feb;164(2):353-358. doi: 
      10.1177/0194599820937296. Epub 2020 Jul 7.