PMID- 32634177
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2155-1790 (Print)
IS  - 2155-1790 (Electronic)
IS  - 2155-1790 (Linking)
VI  - 10
DP  - 2018
TI  - Therapeutic Cocktail Approach for Treatment of Hyperhomocysteinemia in 
      Alzheimer's Disease.
PG  - 2155179017722280
LID - 10.1177/2155179017722280 [doi]
LID - 2155179017722280
AB  - In the United States, Alzheimer's disease (AD) is the most common cause of 
      dementia, accompanied by substantial economic and emotional costs. During 2015, 
      more than 15 million family members who provided care to AD patients had an 
      estimated total cost of 221 billion dollars. Recent studies have shown that 
      elevated total plasma levels of homocysteine (tHcy), a condition known as 
      hyperhomocysteinemia (HHcy), is a risk factor for AD. HHcy is associated with 
      cognitive decline, brain atrophy, and dementia; enhances the vulnerability of 
      neurons to oxidative injury; and damages the blood-brain barrier. Many 
      therapeutic supplements containing vitamin B12 and folate have been studied to 
      help decrease tHcy to a certain degree. However, a therapeutic cocktail approach 
      with 5-methyltetrahydrofolate, methyl B12, betaine, and N-acetylcysteine (NAC) 
      have not been studied. This novel approach may help target multiple pathways 
      simultaneously to decrease tHcy and its toxicity substantially.
CI  - (c) The Author(s) 2018.
FAU - Leon, Michael
AU  - Leon M
AD  - Department of Psychiatry and Behavioral Neurosciences, Rashid Laboratory for 
      Developmental Neurobiology, Silver Child Development Center, Morsani College of 
      Medicine, University of South Florida, Tampa, FL, USA.
FAU - Sawmiller, Darrell
AU  - Sawmiller D
AD  - Department of Psychiatry and Behavioral Neurosciences, Rashid Laboratory for 
      Developmental Neurobiology, Silver Child Development Center, Morsani College of 
      Medicine, University of South Florida, Tampa, FL, USA.
FAU - Shytle, R Douglas
AU  - Shytle RD
AD  - Department of Neurosurgery and Brain Repair, Center for Excellence in Aging and 
      Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, 
      FL, USA.
FAU - Tan, Jun
AU  - Tan J
AD  - Department of Psychiatry and Behavioral Neurosciences, Rashid Laboratory for 
      Developmental Neurobiology, Silver Child Development Center, Morsani College of 
      Medicine, University of South Florida, Tampa, FL, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180125
PL  - United States
TA  - Cell Med
JT  - Cell medicine
JID - 101544564
PMC - PMC6172991
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - N-acetylcysteine (NAC)
OT  - betaine
OT  - folate
OT  - glutathione (GSH)
OT  - hyperhomocysteinemia (HHcy)
OT  - reactive oxygen species (ROS)
OT  - total homocysteine (tHcy)
OT  - vitamin B12
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2018/01/25 00:00
MHDA- 2018/01/25 00:01
PMCR- 2018/01/25
CRDT- 2020/07/08 06:00
PHST- 2020/07/08 06:00 [entrez]
PHST- 2018/01/25 00:00 [pubmed]
PHST- 2018/01/25 00:01 [medline]
PHST- 2018/01/25 00:00 [pmc-release]
AID - 10.1177_2155179017722280 [pii]
AID - 10.1177/2155179017722280 [doi]
PST - epublish
SO  - Cell Med. 2018 Jan 25;10:2155179017722280. doi: 10.1177/2155179017722280. 
      eCollection 2018.