PMID- 32634656
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1873-1597 (Electronic)
IS  - 1572-1000 (Linking)
VI  - 32
DP  - 2020 Dec
TI  - Modified photodynamic therapy to minimize pain in the treatment of condylomata 
      acuminata: A prospective, randomized, self-controlled study.
PG  - 101915
LID - S1572-1000(20)30269-6 [pii]
LID - 10.1016/j.pdpdt.2020.101915 [doi]
AB  - BACKGROUND: Pain is a major concern associated with conventional photodynamic 
      therapy (C-PDT). OBJECTIVE: To evaluate the efficacy, pain and safety of modified 
      photodynamic therapy(M-PDT) for the treatment of condylomata acuminata. METHODS: 
      A prospective, randomized, self-controlled study was conducted. Warts were 
      randomized to the M-PDT or C-PDT side. 5-aminolevulinic acid (ALA; 20 %) was 
      incubated for 3 h before patients were exposed to LED red light (100 J/cm2) on 
      the C-PDT side and for 30 min before being exposed to LED red light (300 J/cm2) 
      on the M-PDT side. Treatment was administered with 1-week interval for three 
      weeks. The clearance rates were determined at one week and the recurrence rates 
      at 4, 8, and 12 weeks after treatment. The pain and other side effects were also 
      investigated. RESULTS: A total of 24 patients with condylomata acuminata were 
      enrolled in this trial. Twenty patients completed the trial. The clearance rates 
      were 98.17 % in the M-PDT side and 98.20 % in the C-PDT side(P > 0.05). The 
      recurrence rates were 11.11 % and 10.53 % (P > 0.05). However, M-PDT was almost 
      painless (mean score 0.3 +/- 0.47, range 0 approximately 1), which was significantly less than 
      that on the C-PDT side (mean score 3.6 +/- 0.94, range 0 approximately 1) (P < 0.05). Local 
      erythema, mild edema and erosion were observed on both sides. CONCLUSION: The 
      modified PDT is basically painless with similar efficacy to conventional PDT, 
      which is a major breakthrough of pain management in PDT.
CI  - Copyright (c) 2020. Published by Elsevier B.V.
FAU - Zhang, Haiyan
AU  - Zhang H
AD  - Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Shi, Lei
AU  - Shi L
AD  - Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Zhang, Yunfeng
AU  - Zhang Y
AD  - Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Wang, Peiru
AU  - Wang P
AD  - Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Zhang, Guolong
AU  - Zhang G
AD  - Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Cao, Yajing
AU  - Cao Y
AD  - Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Zhou, Zhongxia
AU  - Zhou Z
AD  - Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Wang, Xiuli
AU  - Wang X
AD  - Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University 
      School of Medicine, Shanghai, China. Electronic address: 
      wangxiuli_1400023@tongji.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200704
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
RN  - 0 (Photosensitizing Agents)
RN  - 88755TAZ87 (Aminolevulinic Acid)
SB  - IM
MH  - Aminolevulinic Acid/therapeutic use
MH  - *Condylomata Acuminata/drug therapy
MH  - Humans
MH  - Pain/drug therapy
MH  - *Photochemotherapy/methods
MH  - Photosensitizing Agents/therapeutic use
MH  - Prospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - 5-aminolevulinic acid
OT  - Condylomata acuminata
OT  - Pain
OT  - Painless
OT  - Photodynamic therapy
EDAT- 2020/07/08 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/07/08 06:00
PHST- 2020/04/27 00:00 [received]
PHST- 2020/06/27 00:00 [revised]
PHST- 2020/06/29 00:00 [accepted]
PHST- 2020/07/08 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/07/08 06:00 [entrez]
AID - S1572-1000(20)30269-6 [pii]
AID - 10.1016/j.pdpdt.2020.101915 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2020 Dec;32:101915. doi: 
      10.1016/j.pdpdt.2020.101915. Epub 2020 Jul 4.