PMID- 32634783
OWN - NLM
STAT- MEDLINE
DCOM- 20210316
LR  - 20210316
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 12
IP  - 13
DP  - 2020 Jul 7
TI  - Changes of saliva microbiota in the onset and after the treatment of diabetes in 
      patients with periodontitis.
PG  - 13090-13114
LID - 10.18632/aging.103399 [doi]
AB  - The relationship between type 2 diabetes mellitus (T2DM) and oral microbiota is 
      still insufficiently recognized. In the present study, we compared the salivary 
      microbiome of nondiabetic individuals, treatment-naive diabetic patients, and 
      diabetic patients treated with metformin or a combination of insulin and other 
      drugs. The alpha- and beta-diversity demonstrated significant differences in the 
      salivary microbiome between the nondiabetic people and patients with a history of 
      diabetes, while little divergence was found among individuals with a history of 
      diabetes. After characterizing the effects of periodontitis on the microbial 
      composition of each group, the salivary microbiome of the treatment-naive 
      diabetic patient group was compared with that of nondiabetic people and the 
      metformin/combined treatment groups. The results revealed changes in the contents 
      of certain bacteria after both the onset and the treatment of diabetes; among 
      these differential bacteria, Blautia_wexlerae, Lactobacillus_fermentum, 
      Nocardia_coeliaca and Selenomonas_artemidis varied in all processes. A subsequent 
      correlational analysis of the differential bacteria and clinical characteristics 
      demonstrated that salivary microbes were related to drug treatment and certain 
      pathological changes. Finally, the four common differential bacteria were 
      employed for distinguishing the treatment-naive diabetic patients from the 
      nondiabetic people and the treated patients, with prediction accuracies of 83.3%, 
      75% and 75%, respectively.
FAU - Yang, Ying
AU  - Yang Y
AD  - Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, 
      Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 
      Shandong, China.
FAU - Liu, Shili
AU  - Liu S
AD  - Department of Human Microbiome, School and Hospital of Stomatology, Cheeloo 
      College of Medicine, Shandong University, Jinan, Shandong, China.
AD  - Shandong Provincial Key Laboratory of Oral Tissue Regeneration and Shandong 
      Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, 
      Shandong, China.
AD  - School of Basic Medical Science, Cheeloo College of Medicine Shandong University, 
      Jinan, Shandong, China.
FAU - Wang, Yihua
AU  - Wang Y
AD  - Department of Human Microbiome, School and Hospital of Stomatology, Cheeloo 
      College of Medicine, Shandong University, Jinan, Shandong, China.
AD  - Shandong Provincial Key Laboratory of Oral Tissue Regeneration and Shandong 
      Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, 
      Shandong, China.
FAU - Wang, Zhibin
AU  - Wang Z
AD  - Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, 
      Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 
      Shandong, China.
FAU - Ding, Wenyu
AU  - Ding W
AD  - Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, 
      Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 
      Shandong, China.
FAU - Sun, Xiaoyuan
AU  - Sun X
AD  - Shandong University Hospital, Jinan, Shandong, China.
FAU - He, Kunlun
AU  - He K
AD  - Beijing Key Laboratory for Precision Medicine of Chronic Heart Failure, Chinese 
      PLA General Hospital, Beijing, China.
FAU - Feng, Qiang
AU  - Feng Q
AD  - Department of Human Microbiome, School and Hospital of Stomatology, Cheeloo 
      College of Medicine, Shandong University, Jinan, Shandong, China.
AD  - Shandong Provincial Key Laboratory of Oral Tissue Regeneration and Shandong 
      Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, 
      Shandong, China.
AD  - State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 
      Shandong, China.
FAU - Zhang, Xiandang
AU  - Zhang X
AD  - Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, 
      Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 
      Shandong, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200707
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (DNA, Bacterial)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Cohort Studies
MH  - DNA, Bacterial/classification/genetics
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy
MH  - Gastrointestinal Microbiome/*genetics
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Periodontitis/*complications
MH  - Saliva/*microbiology
PMC - PMC7377876
OTO - NOTNLM
OT  - T2DM
OT  - differential bacteria
OT  - microbial markers
OT  - salivary microbiota
OT  - treatment
COIS- CONFLICTS OF INTEREST: The authors indicate no potential conflicts of interest.
EDAT- 2020/07/08 06:00
MHDA- 2021/03/17 06:00
PMCR- 2020/07/15
CRDT- 2020/07/08 06:00
PHST- 2020/01/09 00:00 [received]
PHST- 2020/05/25 00:00 [accepted]
PHST- 2020/07/08 06:00 [pubmed]
PHST- 2021/03/17 06:00 [medline]
PHST- 2020/07/08 06:00 [entrez]
PHST- 2020/07/15 00:00 [pmc-release]
AID - 103399 [pii]
AID - 10.18632/aging.103399 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2020 Jul 7;12(13):13090-13114. doi: 10.18632/aging.103399. 
      Epub 2020 Jul 7.