PMID- 32635423
OWN - NLM
STAT- MEDLINE
DCOM- 20210218
LR  - 20210218
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 13
DP  - 2020 Jul 4
TI  - Role of Human Leukocyte Antigens at the Feto-Maternal Interface in Normal and 
      Pathological Pregnancy: An Update.
LID - 10.3390/ijms21134756 [doi]
LID - 4756
AB  - The successful maternal tolerance of the semi-allogeneic fetus provides an 
      apparent immunologic paradox. Indeed, deep invasion of placental trophoblast 
      cells into maternal uterine tissue and the following growth of the fetus have to 
      be tolerated by a pregnant woman's immune system. Among the various possible 
      protective mechanisms that may be involved in human pregnancy, the expression of 
      a non-classical pattern of human leukocyte antigen (HLA) class I molecules and 
      the complete lack of expression of HLA class II molecules in placental tissues 
      seem to be the most relevant mechanisms of fetal escape from maternal immune 
      recognition. The importance of HLA molecules in fetal toleration by the maternal 
      immune system is highlighted by pregnancy complications occurring in cases of 
      abnormal HLA molecule expression at the maternal-fetal interface. In this review, 
      we summarize evidences about the role of placental HLA molecules in normal and 
      pathological pregnancies.
FAU - Tersigni, Chiara
AU  - Tersigni C
AUID- ORCID: 0000-0003-1590-3942
AD  - Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanita 
      Pubblica, U.O.C. di Ostetricia e Patologia Ostetrica, Fondazione Policlinico 
      Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
FAU - Meli, Federica
AU  - Meli F
AD  - Facolta di Medicina e Chirurgia A. A Gemelli, Universita Cattolica del Sacro 
      Cuore, 00168 Rome, Italy.
FAU - Neri, Caterina
AU  - Neri C
AD  - Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanita 
      Pubblica, U.O.C. di Ostetricia e Patologia Ostetrica, Fondazione Policlinico 
      Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
FAU - Iacoangeli, Azzurra
AU  - Iacoangeli A
AD  - Facolta di Medicina e Chirurgia A. A Gemelli, Universita Cattolica del Sacro 
      Cuore, 00168 Rome, Italy.
FAU - Franco, Rita
AU  - Franco R
AD  - Facolta di Medicina e Chirurgia A. A Gemelli, Universita Cattolica del Sacro 
      Cuore, 00168 Rome, Italy.
FAU - Lanzone, Antonio
AU  - Lanzone A
AD  - Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanita 
      Pubblica, U.O.C. di Ostetricia e Patologia Ostetrica, Fondazione Policlinico 
      Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
AD  - Facolta di Medicina e Chirurgia A. A Gemelli, Universita Cattolica del Sacro 
      Cuore, 00168 Rome, Italy.
FAU - Scambia, Giovanni
AU  - Scambia G
AD  - Facolta di Medicina e Chirurgia A. A Gemelli, Universita Cattolica del Sacro 
      Cuore, 00168 Rome, Italy.
AD  - Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanita 
      Pubblica, U.O.C. di Ginecologia Oncologica, Fondazione Policlinico Universitario 
      A. Gemelli IRCCS, 00168 Rome, Italy.
FAU - Di Simone, Nicoletta
AU  - Di Simone N
AD  - Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanita 
      Pubblica, U.O.C. di Ostetricia e Patologia Ostetrica, Fondazione Policlinico 
      Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
AD  - Facolta di Medicina e Chirurgia A. A Gemelli, Universita Cattolica del Sacro 
      Cuore, 00168 Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200704
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Animals
MH  - Female
MH  - Fetus/*immunology
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Immune Tolerance/immunology
MH  - Maternal-Fetal Exchange/*immunology
MH  - Placenta/immunology
MH  - Pregnancy
MH  - Trophoblasts/immunology
PMC - PMC7370064
OTO - NOTNLM
OT  - Human Leukocyte Antigen (HLA)
OT  - Major Histocompatibility Complex (MHC)
OT  - maternal-fetal interface
OT  - pre-eclampsia.
OT  - pregnancy
OT  - syncytiotrophoblast
COIS- The authors declare no conflict of interest.
EDAT- 2020/07/09 06:00
MHDA- 2021/02/20 06:00
PMCR- 2020/07/01
CRDT- 2020/07/09 06:00
PHST- 2020/05/08 00:00 [received]
PHST- 2020/06/24 00:00 [revised]
PHST- 2020/07/02 00:00 [accepted]
PHST- 2020/07/09 06:00 [entrez]
PHST- 2020/07/09 06:00 [pubmed]
PHST- 2021/02/20 06:00 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - ijms21134756 [pii]
AID - ijms-21-04756 [pii]
AID - 10.3390/ijms21134756 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Jul 4;21(13):4756. doi: 10.3390/ijms21134756.