PMID- 3263703
OWN - NLM
STAT- MEDLINE
DCOM- 19881214
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 242
IP  - 4880
DP  - 1988 Nov 11
TI  - Induction of manganous superoxide dismutase by tumor necrosis factor: possible 
      protective mechanism.
PG  - 941-4
AB  - Manganous superoxide dismutase (MnSOD) scavenges potentially toxic superoxide 
      radicals produced in the mitochondria. Tumor necrosis factor-alpha (TNF-alpha) 
      was found to induce the messenger RNA for MnSOD, but not the mRNAs for other 
      antioxidant or mitochondrial enzymes tested. The increase in MnSOD mRNA occurred 
      rapidly and was blocked by actinomycin D, but not by cycloheximide. Induction of 
      MnSOD mRNA was also observed with TNF-beta, interleukin-1 alpha (IL-1 alpha), and 
      IL-1 beta but not with other cytokines or agents tested. TNF-alpha induced MnSOD 
      mRNA in all cell lines and normal cells examined in vitro and in various organs 
      of mice in vivo. These effects of TNF-alpha and IL-1 on target cells may 
      contribute to their reported protective activity against radiation as well as 
      their ability to induce resistance to cell killing induced by the combination of 
      TNF-alpha and cycloheximide.
FAU - Wong, G H
AU  - Wong GH
AD  - Department of Molecular Biology, Genentech, San Francisco, CA 94080.
FAU - Goeddel, D V
AU  - Goeddel DV
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Interleukin-1)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 1CC1JFE158 (Dactinomycin)
RN  - 98600C0908 (Cycloheximide)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - Catalase/metabolism
MH  - Cell Line
MH  - Cycloheximide/pharmacology
MH  - Dactinomycin/pharmacology
MH  - Enzyme Induction/drug effects
MH  - Humans
MH  - Interleukin-1/pharmacology
MH  - Kinetics
MH  - Mice
MH  - Mitochondria/enzymology
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Superoxide Dismutase/*biosynthesis/genetics/metabolism
MH  - Tissue Distribution
MH  - Tumor Necrosis Factor-alpha/*pharmacology
EDAT- 1988/11/11 00:00
MHDA- 1988/11/11 00:01
CRDT- 1988/11/11 00:00
PHST- 1988/11/11 00:00 [pubmed]
PHST- 1988/11/11 00:01 [medline]
PHST- 1988/11/11 00:00 [entrez]
AID - 10.1126/science.3263703 [doi]
PST - ppublish
SO  - Science. 1988 Nov 11;242(4880):941-4. doi: 10.1126/science.3263703.