PMID- 32638437
OWN - NLM
STAT- MEDLINE
DCOM- 20210907
LR  - 20210907
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 34
IP  - 11
DP  - 2020 Nov
TI  - Reference interval and the role of soluble suppression of tumorigenicity 2 (sST2) 
      in subclinical cardiac dysfunction at health checkups.
PG  - e23461
LID - 10.1002/jcla.23461 [doi]
LID - e23461
AB  - BACKGROUND: Soluble ST2 (sST2) is known to predict adverse outcomes and death in 
      individuals with established heart failure. However, the role of sST2 testing in 
      the general population has not been established. The aims of this study were to 
      determine the reference interval (RI) and the clinical utility of sST2 in 
      subclinical cardiac dysfunction in general population. METHODS: This 
      cross-sectional study consecutively selected 41,806 general subjects at health 
      checkups who underwent echocardiography and sST2 testing at 16 health promotion 
      centers in 13 Korean cities. The reference subjects were obtained among those 
      with normal findings in echocardiography. Sex-specific RIs were established 
      according to the CLSI C28-A3 guidelines. sST2 was measured using immunoassay with 
      the Presage ST2 assay (Critical Diagnostics). RESULTS: In the general subjects, 
      age, sex, BMI, systolic blood pressure, blood glucose, creatinine, liver 
      function, and triglycerides were associated with the sST2 levels. The RI for sST2 
      was higher in males (</=49.6 ng/mL, 95% CI = 48.5-51.5) than in females 
      (</=44.5 ng/mL, 95% CI = 43.5-45.6) and higher in subjects aged < 40 years 
      than >/= 40 years in both sexes. The sST2 levels were 29.1 +/- 10.7 (mean +/- SD) and 
      29.1 +/- 14.4 ng/mL in the groups with normal cardiac function and subclinical 
      cardiac dysfunction, respectively. The sST2 level was not associated with 
      subclinical cardiac dysfunction (odd ratio = 1.002, P = .13). CONCLUSIONS: RIs 
      obtained from a large and echocardiography-proven healthy community-based sample 
      are presented. Subclinical cardiac dysfunction was associated with older age, 
      male sex, and metabolic factors but not with the sST2 level.
CI  - (c) 2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley 
      Periodicals LLC.
FAU - Nah, Eun-Hee
AU  - Nah EH
AUID- ORCID: 0000-0003-0637-4364
AD  - Department of Laboratory Medicine, Health Promotion Research Institute, Korea 
      Association of Health Promotion, Seoul, Korea.
FAU - Cho, Seon
AU  - Cho S
AUID- ORCID: 0000-0002-6432-5897
AD  - Department of Laboratory Medicine, Health Promotion Research Institute, Korea 
      Association of Health Promotion, Seoul, Korea.
FAU - Kim, Suyoung
AU  - Kim S
AUID- ORCID: 0000-0003-0512-1189
AD  - Department of Laboratory Medicine, Health Promotion Research Institute, Korea 
      Association of Health Promotion, Seoul, Korea.
FAU - Cho, Han-Ik
AU  - Cho HI
AUID- ORCID: 0000-0001-6075-7636
AD  - MEDIcheck LAB, Korea Association of Health Promotion, Cheongju, Korea.
LA  - eng
PT  - Journal Article
DEP - 20200707
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (IL1RL1 protein, human)
RN  - 0 (Interleukin-1 Receptor-Like 1 Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Echocardiography
MH  - Female
MH  - *Heart Diseases/blood/diagnosis/epidemiology/physiopathology
MH  - Humans
MH  - Interleukin-1 Receptor-Like 1 Protein/*blood
MH  - Male
MH  - Middle Aged
MH  - Reference Values
PMC - PMC7676181
OTO - NOTNLM
OT  - cardiac dysfunction
OT  - echocardiography
OT  - reference interval
OT  - soluble ST2
EDAT- 2020/07/09 06:00
MHDA- 2021/09/08 06:00
PMCR- 2020/07/07
CRDT- 2020/07/09 06:00
PHST- 2020/06/01 00:00 [received]
PHST- 2020/06/16 00:00 [revised]
PHST- 2020/06/19 00:00 [accepted]
PHST- 2020/07/09 06:00 [pubmed]
PHST- 2021/09/08 06:00 [medline]
PHST- 2020/07/09 06:00 [entrez]
PHST- 2020/07/07 00:00 [pmc-release]
AID - JCLA23461 [pii]
AID - 10.1002/jcla.23461 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2020 Nov;34(11):e23461. doi: 10.1002/jcla.23461. Epub 2020 Jul 
      7.