PMID- 32639946
OWN - NLM
STAT- MEDLINE
DCOM- 20210316
LR  - 20210316
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 12
IP  - 13
DP  - 2020 Jul 8
TI  - A validated survival nomogram for early-onset diffuse gastric cancer.
PG  - 13160-13171
LID - 10.18632/aging.103406 [doi]
AB  - This study aimed to establish and independently validate a prognostic nomogram 
      for individual risk prediction in patients with early-onset diffuse gastric 
      cancer (EODGC). Data for 794 patients with EODGC from the SEER database were 
      randomly assigned to training (N=558) and internal validation (N=236) sets, and 
      data for 82 patients from the Renmin Hospital of Wuhan University (RMHWHU) were 
      used as an independent validation cohort. Our LASSO regression analyses of the 
      training set yielded five clinicopathological features (race, AJCC stage, surgery 
      for primary site, chemotherapy and tumor size), which were used to create a 
      survival nomogram. Our survival nomogram achieved better predictive performance 
      than the AJCC staging system, the current standard. Additionally, the calibration 
      curves of the prognostic nomogram revealed good agreement between the predicted 
      survival probabilities and the ground truth values. Indeed, our nomogram, which 
      estimates individualized survival probabilities for patients with EODGC, shows 
      good predictive accuracy and calibration ability for both the SEER and RMHWHU 
      cohorts. These results suggest that a survival nomogram may be better at 
      predicting OS for EODGC patients than the AJCC staging system.
FAU - Liao, Fei
AU  - Liao F
AD  - Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 
      430061, Hubei Province, China.
FAU - Guo, Xufeng
AU  - Guo X
AD  - Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430061, Hubei 
      Province, China.
FAU - Lu, Xiaohong
AU  - Lu X
AD  - Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 
      430061, Hubei Province, China.
FAU - Dong, Weiguo
AU  - Dong W
AD  - Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 
      430061, Hubei Province, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200708
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
SB  - IM
MH  - Adult
MH  - Databases, Factual
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - *Nomograms
MH  - ROC Curve
MH  - Stomach Neoplasms/*diagnosis/epidemiology/*mortality
MH  - Survival Analysis
PMC - PMC7377898
OTO - NOTNLM
OT  - AJCC stage
OT  - SEER database
OT  - early-onset diffuse gastric cancer
OT  - overall survival
OT  - prognostic nomogram
COIS- CONFLICTS OF INTEREST: The authors declare that there are no conflicts of 
      interest.
EDAT- 2020/07/09 06:00
MHDA- 2021/03/17 06:00
PMCR- 2020/07/15
CRDT- 2020/07/09 06:00
PHST- 2020/02/10 00:00 [received]
PHST- 2020/05/25 00:00 [accepted]
PHST- 2020/07/09 06:00 [pubmed]
PHST- 2021/03/17 06:00 [medline]
PHST- 2020/07/09 06:00 [entrez]
PHST- 2020/07/15 00:00 [pmc-release]
AID - 103406 [pii]
AID - 10.18632/aging.103406 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2020 Jul 8;12(13):13160-13171. doi: 10.18632/aging.103406. 
      Epub 2020 Jul 8.