PMID- 32640336
OWN - NLM
STAT- MEDLINE
DCOM- 20210422
LR  - 20231213
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 143
DP  - 2020 Sep
TI  - Perinatal exposure to glyphosate or a glyphosate-based formulation disrupts 
      hormonal and uterine milieu during the receptive state in rats.
PG  - 111560
LID - S0278-6915(20)30450-6 [pii]
LID - 10.1016/j.fct.2020.111560 [doi]
AB  - We investigated the effects of perinatal exposure to a glyphosate-based herbicide 
      (GBH) or glyphosate alone (Gly) on female fertility and the hormonal and uterine 
      milieu during the preimplantation period. F0 pregnant rats orally received a GBH 
      or Gly in a dose of 2 mg of glyphosate/kg/day from gestational day (GD) 9 until 
      weaning. F1 females were evaluated to determine the reproductive performance on 
      GD19; and the sex steroid serum levels, the expression of estrogen receptor alpha 
      (ERalpha), progesterone receptor (PR) and implantation-related genes on GD5 
      (preimplantation period). GBH and Gly induced preimplantation losses in F1 rats. 
      GBH and Gly groups exhibited higher 17beta-estradiol serum levels, without changes 
      in progesterone. Both compounds increased the uterine ERalpha protein expression, 
      with no differences at transcript level; and only Gly decreased PR mRNA 
      expression. Also, GBH and Gly downregulated Hoxa10 and Lif genes, with no 
      difference in Muc1 and Areg expression. To conclude, perinatal exposure to a GBH 
      or Gly disrupted critical hormonal and uterine molecular targets during the 
      receptive state, possibly associated with the implantation failures. Overall, 
      similar results were found in GBH- and Gly-exposed rats, suggesting that the 
      active principle might be the main responsible for the deleterious effects.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Lorenz, Virginia
AU  - Lorenz V
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral (UNL) - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas (CONICET), Santa Fe, Argentina.
FAU - Pacini, Guillermina
AU  - Pacini G
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral (UNL) - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas (CONICET), Santa Fe, Argentina.
FAU - Luque, Enrique H
AU  - Luque EH
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral (UNL) - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas (CONICET), Santa Fe, Argentina; Catedra de 
      Fisiologia Humana, Facultad de Bioquimica y Ciencias Biologicas, Universidad 
      Nacional del Litoral, Santa Fe, Argentina.
FAU - Varayoud, Jorgelina
AU  - Varayoud J
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral (UNL) - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas (CONICET), Santa Fe, Argentina; Catedra de 
      Fisiologia Humana, Facultad de Bioquimica y Ciencias Biologicas, Universidad 
      Nacional del Litoral, Santa Fe, Argentina.
FAU - Milesi, Maria M
AU  - Milesi MM
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral (UNL) - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas (CONICET), Santa Fe, Argentina; Catedra de 
      Fisiologia Humana, Facultad de Bioquimica y Ciencias Biologicas, Universidad 
      Nacional del Litoral, Santa Fe, Argentina. Electronic address: 
      mmilesi@fbcb.unl.edu.ar.
LA  - eng
PT  - Journal Article
DEP - 20200705
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Herbicides)
RN  - 0 (Hormones)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Embryo Implantation/*drug effects
MH  - Estrus
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Glycine/*analogs & derivatives/toxicity
MH  - Herbicides/*toxicity
MH  - Hormones/*metabolism
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Reproduction/drug effects
MH  - *Uterus
MH  - Glyphosate
OTO - NOTNLM
OT  - 17beta-estradiol
OT  - Estrogen receptor alpha
OT  - Glyphosate
OT  - Implantation
OT  - Implantation-related genes
OT  - Uterus
EDAT- 2020/07/09 06:00
MHDA- 2021/04/23 06:00
CRDT- 2020/07/09 06:00
PHST- 2020/04/06 00:00 [received]
PHST- 2020/06/19 00:00 [revised]
PHST- 2020/06/24 00:00 [accepted]
PHST- 2020/07/09 06:00 [pubmed]
PHST- 2021/04/23 06:00 [medline]
PHST- 2020/07/09 06:00 [entrez]
AID - S0278-6915(20)30450-6 [pii]
AID - 10.1016/j.fct.2020.111560 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2020 Sep;143:111560. doi: 10.1016/j.fct.2020.111560. Epub 2020 
      Jul 5.