PMID- 32640925
OWN - NLM
STAT- MEDLINE
DCOM- 20211203
LR  - 20211214
IS  - 1478-6427 (Electronic)
IS  - 1478-6419 (Linking)
VI  - 35
IP  - 23
DP  - 2021 Dec
TI  - Amicoumacins from a desert bacterium: quorum sensing inhibitor against 
      Chromobacterium violaceum.
PG  - 5508-5512
LID - 10.1080/14786419.2020.1788554 [doi]
AB  - In our study, the anti-quorum sensing (QS) activity of fermentation broth from 
      TRM B-02, a bacterium isolated from Taklimakan desert, was investigated using the 
      biosensor bioassay on Chromobacterium violaceum ATCC12472. TRM B-02 was 100% 
      similar to Bacillus subtilis subsp. Inaquosorum KCTC 13429((T)) by genotypic and 
      phenotypic analyses. Based on anti-QS activity tracking, six known amicoumacins, 
      named as AI-77-H (1), AI-77-F (2), amicoumacin B (3), amicoumacin C (4), AI-77-C 
      (5) and bacilosarcins D (6), were isolated and identified. Among them, compounds 
      1-3 exhibited a better inhibitory effect on C. violaceum ATCC12472. Further 
      research suggested that compounds 1-3 could significantly down-regulate the 
      expressions of violacein operon A (vioA), vioB, vioD and vioE and up-regulate 
      vioC. Docking experiments indicated that compounds 1-3 may act as an inhibitor of 
      violacein biosynthetic pathway competitively inhibiting the binding of flavin 
      adenine dinucleotide (FAD) with the vioD enzyme.[Figure: see text].
FAU - Shi, Wen-Pan
AU  - Shi WP
AD  - Xinjiang Production & Construction Corps Key Laboratory of Protection and 
      Utilization of Biological Resources in Tarim Basin, Tarim University, Alaer, P. 
      R. China.
FAU - Zeng, Hong
AU  - Zeng H
AD  - Xinjiang Production & Construction Corps Key Laboratory of Protection and 
      Utilization of Biological Resources in Tarim Basin, Tarim University, Alaer, P. 
      R. China.
FAU - Wan, Chuan-Xing
AU  - Wan CX
AD  - Xinjiang Production & Construction Corps Key Laboratory of Protection and 
      Utilization of Biological Resources in Tarim Basin, Tarim University, Alaer, P. 
      R. China.
FAU - Zhou, Zhong-Bo
AU  - Zhou ZB
AD  - Xinjiang Production & Construction Corps Key Laboratory of Protection and 
      Utilization of Biological Resources in Tarim Basin, Tarim University, Alaer, P. 
      R. China.
AD  - Engineering Laboratory of Chemical Resources Utilization in South Xinjiang of 
      Xinjiang Production and Construction Corps, Tarim University, Alaer, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20200708
PL  - England
TA  - Nat Prod Res
JT  - Natural product research
JID - 101167924
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Plant Extracts)
RN  - Chromobacterium violaceum
SB  - IM
MH  - *Anti-Bacterial Agents/pharmacology
MH  - Chromobacterium
MH  - Plant Extracts/pharmacology
MH  - *Quorum Sensing
OTO - NOTNLM
OT  - Bacillus subtilis
OT  - Quorum sensing inhibitor
OT  - amicoumacins
EDAT- 2020/07/10 06:00
MHDA- 2021/12/15 06:00
CRDT- 2020/07/10 06:00
PHST- 2020/07/10 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2020/07/10 06:00 [entrez]
AID - 10.1080/14786419.2020.1788554 [doi]
PST - ppublish
SO  - Nat Prod Res. 2021 Dec;35(23):5508-5512. doi: 10.1080/14786419.2020.1788554. Epub 
      2020 Jul 8.