PMID- 32640981 OWN - NLM STAT- MEDLINE DCOM- 20200817 LR - 20210110 IS - 1471-2105 (Electronic) IS - 1471-2105 (Linking) VI - 21 IP - 1 DP - 2020 Jul 8 TI - HEnRY: a DZIF LIMS tool for the collection and documentation of biomaterials in multicentre studies. PG - 290 LID - 10.1186/s12859-020-03596-1 [doi] LID - 290 AB - BACKGROUND: Well-characterized biomaterials of high quality have great potential for acceleration and quality improvement in translational biomedical research. To improve accessibility of local sample collections, efforts have been made to create central biomaterial banks and catalogues. Available technical solutions for creating professional local sample catalogues and connecting them to central systems are cost intensive and/or technically complex to implement. Therefore, the Translational Thematic Unit HIV of the German Center for Infection Research (DZIF) developed a Laboratory Information and Management System (LIMS) called HIV Engaged Research Technology (HEnRY) for implementation into the Translational Platform HIV (TP-HIV) at the DZIF and other research networks. RESULTS: HEnRY is developed at the University Hospital of Cologne. It is an advanced LIMS to manage processing and storage of samples and aliquots of different sample types. Features include: monitoring of stored samples and associated information data selection via query tools or Structured Query Language (SQL) preparation of summary documents, including scannable search lists centralized management of the practical laboratory part of multicentre studies (e.g. import of drawing schemes and sample processing steps), preparation of aliquot shipments, including associated documents to be added to shipments unique and secure identification of aliquots through use of customizable Quick Response (QR) code labels directly from HEnRY support of aliquot data transmission to central registries. In summary, HEnRY offers all features necessary for a LIMS software. In addition, the structure of HEnRY provides sufficient flexibility to allow the implementation in other research areas. CONCLUSION: HEnRY is a free biobanking tool published under the MIT license. While it was developed to support HIV research in Germany, the feature set and language options, allow much broader applications and make this a powerful free research tool. FAU - Heinen, Stephanie AU - Heinen S AD - Faculty of Medicine and University Hospital Cologne, Department I for Internal Medicine, University of Cologne, Herderstr. 52-54, 50931, Cologne, Germany. stephanie.heinen@uk-koeln.de. AD - German Center for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany. stephanie.heinen@uk-koeln.de. FAU - Schulze, Nick AU - Schulze N AD - Faculty of Medicine and University Hospital Cologne, Department I for Internal Medicine, University of Cologne, Herderstr. 52-54, 50931, Cologne, Germany. FAU - Franke, Bernd AU - Franke B AD - Faculty of Medicine and University Hospital Cologne, Department I for Internal Medicine, University of Cologne, Herderstr. 52-54, 50931, Cologne, Germany. FAU - Klein, Florian AU - Klein F AD - Institute of Virology, University Hospital Cologne, Furst-Puckler-Str. 56, 50935, Cologne, Germany. FAU - Lehmann, Clara AU - Lehmann C AD - Medizinisches Versorgungszentrum, Fachbereich Infektiologie, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany. FAU - Vehreschild, Maria J G T AU - Vehreschild MJGT AD - German Center for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany. AD - Head of Infectious Diseases, Department II of Internal Medicine, Goethe University Frankfurt, Frankfurt am Main, Germany. AD - Head of Clinical Microbiome Research Group, Department I for Internal Medicine, University of Cologne, Cologne, Germany. FAU - Gloistein, Claas AU - Gloistein C AD - Faculty of Medicine and University Hospital Cologne, Department II for Internal Medicine, University of Cologne, Cologne, Germany. FAU - Stecher, Melanie AU - Stecher M AD - Faculty of Medicine and University Hospital Cologne, Department I for Internal Medicine, University of Cologne, Herderstr. 52-54, 50931, Cologne, Germany. AD - German Center for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany. FAU - Vehreschild, Jorg Janne AU - Vehreschild JJ AD - Faculty of Medicine and University Hospital Cologne, Department I for Internal Medicine, University of Cologne, Herderstr. 52-54, 50931, Cologne, Germany. AD - German Center for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany. AD - Department of Internal Medicine, Hematology/Oncology, Goethe University Frankfurt, Frankfurt am Main, Germany. LA - eng PT - Journal Article DEP - 20200708 PL - England TA - BMC Bioinformatics JT - BMC bioinformatics JID - 100965194 RN - 0 (Biocompatible Materials) SB - IM MH - Biocompatible Materials MH - *Biological Specimen Banks MH - Computer Systems MH - Data Management MH - Documentation MH - Humans MH - Laboratories MH - Multicenter Studies as Topic MH - *Software PMC - PMC7346399 OTO - NOTNLM OT - Biobanking OT - DZIF OT - LIMS OT - Multicentre studies OT - Sample documentation OT - Sample management OT - Sample processing OT - Sample storage OT - TI biobanking OT - TP HIV COIS- The authors declare that they have no competing interests. EDAT- 2020/07/10 06:00 MHDA- 2020/08/18 06:00 PMCR- 2020/07/08 CRDT- 2020/07/10 06:00 PHST- 2019/09/12 00:00 [received] PHST- 2020/06/10 00:00 [accepted] PHST- 2020/07/10 06:00 [entrez] PHST- 2020/07/10 06:00 [pubmed] PHST- 2020/08/18 06:00 [medline] PHST- 2020/07/08 00:00 [pmc-release] AID - 10.1186/s12859-020-03596-1 [pii] AID - 3596 [pii] AID - 10.1186/s12859-020-03596-1 [doi] PST - epublish SO - BMC Bioinformatics. 2020 Jul 8;21(1):290. doi: 10.1186/s12859-020-03596-1.