PMID- 32641664
OWN - NLM
STAT- MEDLINE
DCOM- 20210222
LR  - 20210222
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Print)
IS  - 0918-2918 (Linking)
VI  - 59
IP  - 20
DP  - 2020 Oct 15
TI  - Two-year Follow-up Results of Magnetic Resonance Imaging-guided Focused 
      Ultrasound Unilateral Thalamotomy for Medication-refractory Essential Tremor.
PG  - 2481-2483
LID - 10.2169/internalmedicine.4360-19 [doi]
AB  - Objective To investigate the long-term efficacy and safety of magnetic resonance 
      imaging-guided focused ultrasound (MRgFUS) unilateral ventral intermediate 
      nucleus (Vim) thalamotomy for medication-refractory essential tremor (ET). 
      Methods We performed MRgFUS left-sided Vim thalamotomy for 10 
      medication-refractory ET patients (8 men and 2 women, aged 67.1+/-17.5 years, all 
      right-handed). We followed them for 2 years using the clinical rating scale for 
      tremor (CRST) and the quality of life in essential tremor questionnaire (QUEST). 
      Results Right-handed tremor improved immediately after the left Vim thalamotomy 
      in all patients. The tremor became re-exacerbated in 2 patients by 6 months after 
      treatment; however, an approximately 60% decrease in the average CRST score of 
      the right hand persisted until 2 years. On the other hand, the average CRST score 
      of the left hand and the average QUEST score showed no improvement. Headache was 
      the most common adverse event during the sonication (8 patients), followed by a 
      floating sensation (4 patients). On the other hand, sensory disturbances (4 
      patients) and gait instability (4 patients) were observed after the treatment, 
      but most of them were mild and transient. There were no delayed adverse events. 
      Conclusion MRgFUS unilateral Vim thalamotomy could be adopted as one of the 
      therapeutic options for intractable ET. Further improvement of tremor in the 
      targeted hand or contralateral Vim thalamotomy may be necessary to improve the 
      quality of life.
FAU - Ito, Hisashi
AU  - Ito H
AD  - Department of Neurology, Shonan Fujisawa Tokushukai Hospital, Japan.
FAU - Yamamoto, Kazuaki
AU  - Yamamoto K
AD  - Department of Neurosurgery, Tokyo Women's Medical University, Japan.
FAU - Fukutake, Shigeru
AU  - Fukutake S
AD  - Department of Neurology, Shonan Fujisawa Tokushukai Hospital, Japan.
FAU - Odo, Takashi
AU  - Odo T
AD  - Department of Neurology, Shonan Fujisawa Tokushukai Hospital, Japan.
FAU - Kamei, Tetsumasa
AU  - Kamei T
AD  - Department of Neurology, Shonan Fujisawa Tokushukai Hospital, Japan.
LA  - eng
PT  - Journal Article
DEP - 20200707
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Essential Tremor/*etiology/*surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Gait Disorders, Neurologic/*diagnostic imaging/*surgery
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*complications
MH  - Thalamus/*diagnostic imaging/*surgery
MH  - Treatment Outcome
MH  - Ultrasonography, Interventional/methods
PMC - PMC7662049
OTO - NOTNLM
OT  - MRI-guided focused ultrasound
OT  - essential tremor
OT  - thalamotomy
OT  - ventral intermediate nucleus
COIS- The authors state that they have no Conflict of Interest (COI).
EDAT- 2020/07/10 06:00
MHDA- 2021/02/23 06:00
PMCR- 2020/10/15
CRDT- 2020/07/10 06:00
PHST- 2020/07/10 06:00 [pubmed]
PHST- 2021/02/23 06:00 [medline]
PHST- 2020/07/10 06:00 [entrez]
PHST- 2020/10/15 00:00 [pmc-release]
AID - 10.2169/internalmedicine.4360-19 [doi]
PST - ppublish
SO  - Intern Med. 2020 Oct 15;59(20):2481-2483. doi: 10.2169/internalmedicine.4360-19. 
      Epub 2020 Jul 7.