PMID- 32643224
OWN - NLM
STAT- MEDLINE
DCOM- 20210331
LR  - 20210331
IS  - 1521-3773 (Electronic)
IS  - 1433-7851 (Linking)
VI  - 59
IP  - 41
DP  - 2020 Oct 5
TI  - Carrier-Free Delivery of Precise Drug-Chemogene Conjugates for Synergistic 
      Treatment of Drug-Resistant Cancer.
PG  - 17944-17950
LID - 10.1002/anie.202006895 [doi]
AB  - Combinatorial antitumor therapies using different combinations of drugs and genes 
      are emerging as promising ways to overcome drug resistance, which is a major 
      cause for the failure of cancer treatment. However, dramatic pharmacokinetic 
      differences of drugs greatly impede their combined use in cancer therapy, raising 
      the demand for drug delivery systems (DDSs) for tumor treatment. By employing 
      fluorescent dithiomaleimide (DTM) as a linker, we conjugate two paclitaxel (PTX) 
      molecules with a floxuridine (FdU)-integrated antisense oligonucleotide (termed 
      chemogene) to form a drug-chemogene conjugate. This PTX-chemogene conjugate can 
      self-assemble into a spherical nucleic acid (SNA)-like micellular nanoparticle as 
      a carrier-free DDS, which knocks down the expression of P-glycoprotein and 
      subsequently releases FdU and PTX to exert a synergistic antitumor effect and 
      greatly inhibit tumor growth.
CI  - (c) 2020 Wiley-VCH GmbH.
FAU - Zhu, Lijuan
AU  - Zhu L
AD  - Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai 
      Jiao Tong University, 160 Pujian Road, Shanghai, 200127, China.
AD  - School of Chemistry and Chemical Engineering, Frontiers Science Center for 
      Transformative Molecules, and, State Key Laboratory of Metal Matrix Composites, 
      Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
FAU - Guo, Yuanyuan
AU  - Guo Y
AD  - School of Chemistry and Chemical Engineering, Frontiers Science Center for 
      Transformative Molecules, and, State Key Laboratory of Metal Matrix Composites, 
      Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
FAU - Qian, Qiuhui
AU  - Qian Q
AD  - School of Chemistry and Chemical Engineering, Frontiers Science Center for 
      Transformative Molecules, and, State Key Laboratory of Metal Matrix Composites, 
      Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
FAU - Yan, Deyue
AU  - Yan D
AD  - Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai 
      Jiao Tong University, 160 Pujian Road, Shanghai, 200127, China.
AD  - School of Chemistry and Chemical Engineering, Frontiers Science Center for 
      Transformative Molecules, and, State Key Laboratory of Metal Matrix Composites, 
      Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
FAU - Li, Yuehua
AU  - Li Y
AD  - Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine, 600, Yi Shan Road, 
      Shanghai, 200233, China.
FAU - Zhu, Xinyuan
AU  - Zhu X
AD  - School of Chemistry and Chemical Engineering, Frontiers Science Center for 
      Transformative Molecules, and, State Key Laboratory of Metal Matrix Composites, 
      Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
FAU - Zhang, Chuan
AU  - Zhang C
AUID- ORCID: 0000-0002-9311-0799
AD  - School of Chemistry and Chemical Engineering, Frontiers Science Center for 
      Transformative Molecules, and, State Key Laboratory of Metal Matrix Composites, 
      Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200813
PL  - Germany
TA  - Angew Chem Int Ed Engl
JT  - Angewandte Chemie (International ed. in English)
JID - 0370543
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*therapeutic use
MH  - Drug Resistance, Neoplasm/*drug effects
MH  - HeLa Cells
MH  - Humans
MH  - Mice
MH  - Microscopy, Atomic Force
MH  - Microscopy, Electron, Transmission
MH  - Neoplasms/*drug therapy
OTO - NOTNLM
OT  - chemotherapy
OT  - drug delivery
OT  - gene therapy
OT  - nucleoside analogue
OT  - self-assembly
EDAT- 2020/07/10 06:00
MHDA- 2021/04/01 06:00
CRDT- 2020/07/10 06:00
PHST- 2020/05/13 00:00 [received]
PHST- 2020/06/26 00:00 [revised]
PHST- 2020/07/10 06:00 [pubmed]
PHST- 2021/04/01 06:00 [medline]
PHST- 2020/07/10 06:00 [entrez]
AID - 10.1002/anie.202006895 [doi]
PST - ppublish
SO  - Angew Chem Int Ed Engl. 2020 Oct 5;59(41):17944-17950. doi: 
      10.1002/anie.202006895. Epub 2020 Aug 13.