PMID- 32643487
OWN - NLM
STAT- MEDLINE
DCOM- 20210303
LR  - 20220531
IS  - 1502-3850 (Electronic)
IS  - 0001-6357 (Linking)
VI  - 79
IP  - 2
DP  - 2021 Mar
TI  - Genetic polymorphisms in interleukin-6 and interleukin-1-beta were associated 
      with dental caries and gingivitis.
PG  - 96-102
LID - 10.1080/00016357.2020.1788722 [doi]
AB  - OBJECTIVE: Evaluate the association between single nucleotide polymorphisms 
      (SNPs) in Interleukin-6 (IL-6) gene (rs1800795) and in Interleukin-1-beta (IL-1beta) 
      gene (rs1143627 and rs1143629) with dental caries and gingivitis in Brazilian 
      children. MATERIAL AND METHODS: Three hundred and fifty-three children aged 
      8-11 years were included. Visible biofilm and gingival bleeding were evaluated by 
      Community Periodontal Index. The International System for Detection and 
      Assessment of Carious Lesions (ICDAS) was used to investigate dental caries. 
      Real-time PCR evaluated SNPs in the DNA. Chi-square test, haplotype analysis and 
      logistic regression were applied (alpha of 5%). RESULTS: The GG genotype in 
      rs1800795 (IL-6) decreases the risk of gingivitis in a co-dominant model 
      (p = .05; OR = 0.64). The GG genotype in rs1143627 (IL-1beta) reduces the risk of 
      dental caries (Co-dominant model: ICDAS(0) versus ICDAS(1-6): p = .05; OR = 0.55. 
      ICDAS(0-2) versus ICDAS(3-6): p = .02; OR = 0.49. Recessive model: ICDAS(0) 
      versus ICDAS(1-6): p = .005; OR = 0.48. ICDAS(0-2) versus ICDAS(3-6): p = .004; 
      OR = 0.45. Logistic regression: ICDAS(0-2) versus ICDAS(3-6): p = .05; OR = 0.24; 
      CI 95%= 0.05-1.00). The GG genotype in rs1143629 was more frequent in ICDAS(0) 
      (p = .05; OR: 0.60). In the haplotype analysis, IL-1beta was associated with 
      gingivitis. CONCLUSION: The rs1800795 in IL-6 gene was associated with 
      gingivitis. The rs1143627 and rs1143629 in IL-1beta were associated with dental 
      caries and gingivitis.
FAU - Reis, Caio Luiz Bitencourt
AU  - Reis CLB
AUID- ORCID: 0000-0003-0606-1632
AD  - School of Dentistry, Federal University of Alfenas, Minas Gerais, Brazil.
FAU - Barbosa, Mariane Carolina Faria
AU  - Barbosa MCF
AUID- ORCID: 0000-0002-2870-8364
AD  - School of Dentistry, Federal University of Alfenas, Minas Gerais, Brazil.
FAU - Machado, Barbara Maria de Souza Moreira
AU  - Machado BMSM
AUID- ORCID: 0000-0002-0338-8667
AD  - School of Dentistry, Federal University of Alfenas, Minas Gerais, Brazil.
FAU - Baratto, Samantha Schaffer Pugsley
AU  - Baratto SSP
AUID- ORCID: 0000-0001-6682-5601
AD  - School of Health Sciences, Positivo University, Curitiba, Brazil.
FAU - de Lima, Daniela Coelho
AU  - de Lima DC
AUID- ORCID: 0000-0002-7945-435X
AD  - School of Dentistry, Federal University of Alfenas, Minas Gerais, Brazil.
FAU - Paza, Aleysson Olimpio
AU  - Paza AO
AD  - School of Health Science, University of Joinville, Joinville, Brazil.
FAU - Filho, Flares Baratto
AU  - Filho FB
AUID- ORCID: 0000-0002-5649-7234
AD  - School of Health Sciences, Positivo University, Curitiba, Brazil.
FAU - Brancher, Joao Armando
AU  - Brancher JA
AUID- ORCID: 0000-0002-8914-702X
AD  - School of Health Sciences, Positivo University, Curitiba, Brazil.
FAU - Kuchler, Erika Calvano
AU  - Kuchler EC
AUID- ORCID: 0000-0001-5351-2526
AD  - School of Health Sciences, Positivo University, Curitiba, Brazil.
FAU - de Oliveira, Daniela Silva Barroso
AU  - de Oliveira DSB
AUID- ORCID: 0000-0003-2691-1411
AD  - School of Dentistry, Federal University of Alfenas, Minas Gerais, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20200709
PL  - Sweden
TA  - Acta Odontol Scand
JT  - Acta odontologica Scandinavica
JID - 0370344
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Brazil
MH  - Child
MH  - Dental Caries/*genetics
MH  - Genotype
MH  - Gingivitis/*genetics
MH  - Humans
MH  - Interleukin-1beta/*genetics
MH  - Interleukin-6/*genetics
OTO - NOTNLM
OT  - Dental caries
OT  - genetic polymorphisms
OT  - gingivitis
OT  - interleukin 1 beta
OT  - interleukin 6
EDAT- 2020/07/10 06:00
MHDA- 2021/03/04 06:00
CRDT- 2020/07/10 06:00
PHST- 2020/07/10 06:00 [pubmed]
PHST- 2021/03/04 06:00 [medline]
PHST- 2020/07/10 06:00 [entrez]
AID - 10.1080/00016357.2020.1788722 [doi]
PST - ppublish
SO  - Acta Odontol Scand. 2021 Mar;79(2):96-102. doi: 10.1080/00016357.2020.1788722. 
      Epub 2020 Jul 9.