PMID- 32643639
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220415
IS  - 0970-2113 (Print)
IS  - 0974-598X (Electronic)
IS  - 0970-2113 (Linking)
VI  - 37
IP  - 4
DP  - 2020 Jul-Aug
TI  - Exploring the effect of presence and type of allergen sensitization on fractional 
      exhaled nitric oxide, immunoglobulin E, and interleukins 4, 5, and 13 among 
      asthmatics.
PG  - 310-315
LID - 10.4103/lungindia.lungindia_493_19 [doi]
AB  - OBJECTIVE: Asthma is associated with airway inflammation. Allergen sensitization 
      (atopy) is common in asthma. This study explored the effect of food and/or 
      aeroallergen sensitization; on airway and systemic inflammation using fractional 
      exhaled nitric oxide (FE(NO)) and interleukins (ILs) 4, 5, and 13. METHODS: The 
      study enrolled asthmatics (diagnosed using Global Initiative for Asthma 
      guidelines). Atopy was diagnosed using skin-prick testing (SPT). All subjects 
      underwent testing for FE(NO), blood absolute eosinophil count (AEC), and serum 
      levels of immunoglobulin E (IgE), and ILs 4, 5, and 13. Asthmatics (BA) were 
      classified as atopic (BA-A) and nonatopic (BA-N). Atopic-asthmatics were 
      subclassified as exclusively food allergen (AtAA) or aeroallergen (AtAA); or 
      dually (AtFAA) sensitized. RESULTS: The study enrolled 203 asthmatics (BA) and 50 
      controls. Among BA, 169 were BA-A and 34 were BA-N. Mean values of AEC, serum IgE 
      and FE(NO), and ILs 4 and 13 were significantly higher in BA-A than BA-N (659 vs. 
      218/mm(3), 638 vs. 217 IU/ml, 39.2 vs. 20.0 ppb, 14.96 vs. 8.04 pg/ml, and 22.12 
      vs. 11.64 pg/ml, respectively). Meanwhile, mean IL-5 was higher in BA-A (11.01 
      vs. 8.76 pg/ml; P = 0.22), but not statistically significant. Subgroup analysis 
      of atopic asthmatics (i.e., AtFA, AtAA, and AtFAA), revealed similar mean values 
      for FE(NO) (31.99 vs. 40.16 vs. 39.46 ppb), AEC (691.00 vs. 653.07 vs. 
      659.88/mm(3)), IgE (635.60 vs. 630.32 vs. 646.39 IU/ml), IL-4 (12.63 vs. 14.74 
      vs. 15.44 pg/ml), and IL-13 (18.38 vs. 19.87 vs. 24.57 pg/ml). No difference was 
      observed among subgroups of atopic-asthmatics. CONCLUSION: Subgroups of 
      atopic-asthmatics did not show any consistent difference across all the studied 
      parameters.
FAU - Malhotra, Nipun
AU  - Malhotra N
AD  - Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, New Delhi, 
      India.
FAU - Gupta, Nitesh
AU  - Gupta N
AD  - Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung 
      Hospital, New Delhi, India.
FAU - Kumar, Raj
AU  - Kumar R
AD  - Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, New Delhi, 
      India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Lung India
JT  - Lung India : official organ of Indian Chest Society
JID - 8405380
PMC - PMC7507927
OTO - NOTNLM
OT  - Aero allergen
OT  - atopic
OT  - biomarkers
OT  - food allergen
OT  - nonatopic
COIS- None
EDAT- 2020/07/10 06:00
MHDA- 2020/07/10 06:01
PMCR- 2020/07/01
CRDT- 2020/07/10 06:00
PHST- 2020/07/10 06:00 [entrez]
PHST- 2020/07/10 06:00 [pubmed]
PHST- 2020/07/10 06:01 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - LungIndia_2020_37_4_310_288750 [pii]
AID - LI-37-310 [pii]
AID - 10.4103/lungindia.lungindia_493_19 [doi]
PST - ppublish
SO  - Lung India. 2020 Jul-Aug;37(4):310-315. doi: 10.4103/lungindia.lungindia_493_19.