PMID- 32644206
OWN - NLM
STAT- MEDLINE
DCOM- 20210824
LR  - 20231213
IS  - 1600-0560 (Electronic)
IS  - 0303-6987 (Linking)
VI  - 47
IP  - 12
DP  - 2020 Dec
TI  - Nevus cell aggregates massively occupying parenchyma of an external iliac lymph 
      node: A case report and review of the literature.
PG  - 1175-1180
LID - 10.1111/cup.13805 [doi]
AB  - We report a case of nevus cell aggregates (NCAs) in an external iliac lymph node 
      from a patient with a compound congenital nevus in the corresponding drainage 
      skin. Melanocytes in parenchyma were in band, nest-like or nodular fashion, and 
      partly continuous with those in capsule and trabeculae. The largest nodule in 
      parenchyma measured 6.5 mm. Melanocytes mostly exhibited benign appearance 
      identical to cutaneous nevus. A few regions abundant in cells displayed atypical 
      features, including increased nucleo-cytoplasmic ratio, small nucleoli, and 
      occasional mitotic figures. Immunohistochemistry showed that melanocytes stained 
      positive for p16, but negative for HMB-45 and nestin. Ki-67 labeling was less 
      than 1% and reticulin mainly surrounded individual melanocytes. Besides, Vysis 
      melanoma fluorescence in situ hybridization (FISH) plus another 2 probes 
      targeting 9p21(CDKN2A) and 8q24(MYC) showed normal results. The patient is alive 
      without malignant tumor after 52-month follow up. Our case provides a new 
      evidence for the existence of intraparenchymal NCAs in deep lymph node and 
      indicates that melanocytes with some atypical features can occur in nodal nevi. 
      Nevus cells in parenchyma connected to those in capsule and trabeculae are a 
      significant clue to distinguish nodal nevi from metastatic melanomas. 
      Additionally, immunohistochemistry and FISH assay are useful in differential 
      diagnosis.
CI  - (c) 2020 John Wiley & Sons A/S . Published by John Wiley & Sons Ltd.
FAU - Hu, Jue
AU  - Hu J
AUID- ORCID: 0000-0003-3221-5957
AD  - Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 
      People's Republic of China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 
      People's Republic of China.
FAU - Ren, Min
AU  - Ren M
AD  - Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 
      People's Republic of China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 
      People's Republic of China.
FAU - Cai, Xu
AU  - Cai X
AD  - Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 
      People's Republic of China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 
      People's Republic of China.
FAU - Zhang, Yan
AU  - Zhang Y
AUID- ORCID: 0000-0001-7387-8269
AD  - Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 
      People's Republic of China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 
      People's Republic of China.
FAU - Lv, Jiao-Jie
AU  - Lv JJ
AD  - Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 
      People's Republic of China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 
      People's Republic of China.
FAU - Kong, Yun-Yi
AU  - Kong YY
AUID- ORCID: 0000-0001-9547-5890
AD  - Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 
      People's Republic of China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 
      People's Republic of China.
LA  - eng
GR  - 19MC1911000/Shanghai Science and Technology Development Foundation/
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20200910
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cell Aggregation
MH  - Diagnosis, Differential
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Ilium/*pathology
MH  - Immunohistochemistry/methods
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Lymph Nodes/*pathology
MH  - Lymphatic Metastasis/diagnosis/pathology
MH  - Male
MH  - Melanocytes/metabolism/*pathology
MH  - Melanoma/diagnosis/secondary
MH  - Middle Aged
MH  - Nevus/pathology
MH  - Nevus, Pigmented/congenital/*pathology/ultrastructure
MH  - Skin Neoplasms/diagnosis/secondary
MH  - Melanoma, Cutaneous Malignant
OTO - NOTNLM
OT  - FISH
OT  - congenital nevus
OT  - immunohistochemistry
OT  - nevus cell aggregates
OT  - nodal nevi
EDAT- 2020/07/10 06:00
MHDA- 2021/08/25 06:00
CRDT- 2020/07/10 06:00
PHST- 2020/03/20 00:00 [received]
PHST- 2020/06/30 00:00 [revised]
PHST- 2020/07/01 00:00 [accepted]
PHST- 2020/07/10 06:00 [pubmed]
PHST- 2021/08/25 06:00 [medline]
PHST- 2020/07/10 06:00 [entrez]
AID - 10.1111/cup.13805 [doi]
PST - ppublish
SO  - J Cutan Pathol. 2020 Dec;47(12):1175-1180. doi: 10.1111/cup.13805. Epub 2020 Sep 
      10.