PMID- 3264588
OWN - NLM
STAT- MEDLINE
DCOM- 19890201
LR  - 20071115
IS  - 0368-2811 (Print)
IS  - 0368-2811 (Linking)
VI  - 18
IP  - 4
DP  - 1988 Dec
TI  - Immunodeficiency in preclinical smoldering adult T-cell leukemia.
PG  - 363-9
AB  - We treated two Japanese patients with Pneumocystis carinii pneumonia. Inclusion 
      bodies in both adrenal glands of patient no. 1 indicated a herpesvirus infection. 
      The patient no. 2 recovered from the pneumonia upon sulfametoxazole-trimethoprim 
      medication and high-dose methylprednisolone therapy. In both patients, anti-human 
      T-cell leukemia virus type I (HTLV-I) antibodies were positive and anti-human 
      immunodeficiency virus antibodies were negative. Peripheral leukocytes in patient 
      no. 1 numbered 13.6 X 10(3)/microliter with 25% morphologically normal 
      lymphocytes and 4% abnormal. Lymphocyte surface markers were 72.6%, CD4+, 13.6% 
      CD8+ and 46.4% CD3+. In patient no. 2, leukocytes numbered 13.8 X 
      10(3)/microliter, including 18% lymphocytes, although no morphologically abnormal 
      lymphocyte was evident. Lymphocyte markers were 36.6% CD4+, 16.8% CD8+ and 46.6% 
      CD3+. Monoclonal integration HTLV-I proviral DNA in lymphocytes of patient no. 2 
      was demonstrated by Southern blotting. Thus, both patients must have had 
      smoldering adult T-cell leukemia (ATL) without any cutaneous involvement, whereas 
      the morphological diagnosis from peripheral blood smears was one of HTLV-I 
      carrier status with a few atypical lymphocytes, i.e., the preclinical state of 
      smoldering ATL. Pneumocystis carinii infections, a viral infection of the 
      adrenals (no. 1), negative purified protein derivatives of the tuberculin 
      reaction and suppressed blastogenesis of the peripheral lymphocytes indicated 
      HTLV-I-induced impairment of the immune mechanism to have already occurred in 
      both patients without there being a vast proliferation of ATL cells.
FAU - Moriyama, K
AU  - Moriyama K
AD  - Department of Internal Medicine, Hamanomachi General Hospital, Fukuoka.
FAU - Muranishi, H
AU  - Muranishi H
FAU - Nishimura, J
AU  - Nishimura J
FAU - Tanaka, K
AU  - Tanaka K
FAU - Asayama, R
AU  - Asayama R
FAU - Takita, A
AU  - Takita A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Jpn J Clin Oncol
JT  - Japanese journal of clinical oncology
JID - 0313225
SB  - IM
MH  - Adult
MH  - Humans
MH  - Immune Tolerance
MH  - Leukemia-Lymphoma, Adult T-Cell/blood/*immunology/pathology
MH  - Male
MH  - Pneumonia, Pneumocystis/immunology/pathology
EDAT- 1988/12/01 00:00
MHDA- 1988/12/01 00:01
CRDT- 1988/12/01 00:00
PHST- 1988/12/01 00:00 [pubmed]
PHST- 1988/12/01 00:01 [medline]
PHST- 1988/12/01 00:00 [entrez]
PST - ppublish
SO  - Jpn J Clin Oncol. 1988 Dec;18(4):363-9.