PMID- 32646924
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20221207
IS  - 2052-4897 (Electronic)
IS  - 2052-4897 (Linking)
VI  - 8
IP  - 1
DP  - 2020 Jul
TI  - Incidence of diabetes and prediabetes and predictors of glycemic change among 
      South Asians in the USA: the MASALA study.
LID - 10.1136/bmjdrc-2019-001063 [doi]
LID - e001063
AB  - INTRODUCTION: South Asians have a high prevalence of type 2 diabetes mellitus 
      (T2DM). This may be associated with high rates of conversion through the natural 
      history of disease. However, there is a paucity of data on prediabetes and T2DM 
      incidence and related predictors in South Asians in the USA. RESEARCH DESIGN AND 
      METHODS: We estimated prediabetes and T2DM incidence after 5 years of follow-up 
      in the Mediators of Atherosclerosis in South Asians Living in America study 
      (n=481) and examined the associated correlates. We defined T2DM and prediabetes 
      using the American Diabetes Association criteria. Prediabetes included isolated 
      impaired fasting glucose (iIFG), isolated impaired glucose tolerance (iIGT) and 
      combined IFG and IGT. RESULTS: Overall, 152 (32%, 95% CI: 27.6 to 35.9) 
      individuals progressed either from normal glucose tolerance to prediabetes or 
      T2DM, or from prediabetes to T2DM. In standardised logistic regression models 
      controlling for age and sex, only hepatic fat attenuation (increased hepatic fat) 
      (OR: 0.67 (95% CI: 0.55 to 0.87) per SD, visceral fat area (OR: 1.36 (95% CI: 
      1.06 to 1.74) per SD and hypertension (OR: 2.21 (95% CI: 1.44 to 3.40) were 
      associated with any glycemic progression. CONCLUSIONS: South Asians in the USA 
      have a high incidence of dysglycemia. Hepatic and visceral fat may be factors in 
      glycemic progression, and prevention efforts should target ectopic fat reduction.
CI  - (c) Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Gujral, Unjali P
AU  - Gujral UP
AUID- ORCID: 0000-0002-0352-813X
AD  - Rollins School of Public Health, Hubert Department of Global Health, Emory 
      University, Atlanta, Georgia, USA ugujral@emory.edu.
FAU - Narayan, K M Venkat
AU  - Narayan KMV
AD  - Hubert Department of Global Health, Emory RSPH, Atlanta, Georgia, USA.
FAU - Kandula, Namratha R
AU  - Kandula NR
AD  - Division of General Internal Medicine, Northwestern University, Chicago, 
      Illinois, USA.
FAU - Liu, Kiang
AU  - Liu K
AD  - Department of Community Health & Preventive Medicine, Northwestern University 
      Medical School, Chicago, Illinois, USA.
FAU - Kanaya, Alka M
AU  - Kanaya AM
AD  - Epidemiology and Biostatistics-Diabetes Center, University of California San 
      Francisco, San Francisco, California, USA.
LA  - eng
GR  - M01 RR001271/RR/NCRR NIH HHS/United States
GR  - K24 HL112827/HL/NHLBI NIH HHS/United States
GR  - P30 DK098722/DK/NIDDK NIH HHS/United States
GR  - R01 HL125442/HL/NHLBI NIH HHS/United States
GR  - P30 DK092924/DK/NIDDK NIH HHS/United States
GR  - UL1 RR024131/RR/NCRR NIH HHS/United States
GR  - P30 DK111024/DK/NIDDK NIH HHS/United States
GR  - R01 HL093009/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - BMJ Open Diabetes Res Care
JT  - BMJ open diabetes research & care
JID - 101641391
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Asian People
MH  - Blood Glucose
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - Humans
MH  - Incidence
MH  - *Prediabetic State/epidemiology
MH  - United States/epidemiology
PMC - PMC7351272
OTO - NOTNLM
OT  - Asian Indians
OT  - impaired fasting glucose
OT  - incidence
OT  - type 2 diabetes
COIS- Competing interests: None declared.
EDAT- 2020/07/11 06:00
MHDA- 2021/06/22 06:00
PMCR- 2020/07/09
CRDT- 2020/07/11 06:00
PHST- 2019/11/19 00:00 [received]
PHST- 2020/03/26 00:00 [revised]
PHST- 2020/06/06 00:00 [accepted]
PHST- 2020/07/11 06:00 [entrez]
PHST- 2020/07/11 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/07/09 00:00 [pmc-release]
AID - 8/1/e001063 [pii]
AID - bmjdrc-2019-001063 [pii]
AID - 10.1136/bmjdrc-2019-001063 [doi]
PST - ppublish
SO  - BMJ Open Diabetes Res Care. 2020 Jul;8(1):e001063. doi: 
      10.1136/bmjdrc-2019-001063.