PMID- 3264880
OWN - NLM
STAT- MEDLINE
DCOM- 19890223
LR  - 20210526
IS  - 0270-7306 (Print)
IS  - 1098-5549 (Electronic)
IS  - 0270-7306 (Linking)
VI  - 8
IP  - 8
DP  - 1988 Aug
TI  - Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 
      2/interleukin 6.
PG  - 3546-9
AB  - B-cell stimulatory factor 2 (BSF-2) is a lymphokine which induces the final 
      maturation of B cells. BSF-2 acts on a variety of cells other than B cells, and 
      moreover, expression of BSF-2 mRNA is detected in interleukin-1 beta-stimulated 
      glioblastoma and astrocytoma cell lines. Here, we studied the function of BSF-2 
      on pheochromocytoma PC12 cells, a model system for induction of neuronal 
      differentiation. PC12 cells possess specific receptors for BSF-2. The 
      BSF-2-stimulated PC12 cells expressed the c-fos proto-oncogene transiently, and 
      they began to change morphologically to neurite-extending cells after several 
      days. The number of voltage-dependent Na+ channels was also increased.
FAU - Satoh, T
AU  - Satoh T
AD  - Institute of Medical Science, University of Tokyo, Japan.
FAU - Nakamura, S
AU  - Nakamura S
FAU - Taga, T
AU  - Taga T
FAU - Matsuda, T
AU  - Matsuda T
FAU - Hirano, T
AU  - Hirano T
FAU - Kishimoto, T
AU  - Kishimoto T
FAU - Kaziro, Y
AU  - Kaziro Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adrenal Gland Neoplasms
MH  - Animals
MH  - Cell Differentiation/*drug effects
MH  - Cell Line
MH  - Interleukin-6
MH  - Interleukins/*pharmacology
MH  - Kinetics
MH  - Neurons/*cytology
MH  - Oncogenes/drug effects
MH  - Pheochromocytoma
MH  - RNA, Messenger/genetics
MH  - Transcription, Genetic/drug effects
PMC - PMC363593
EDAT- 1988/08/01 00:00
MHDA- 1988/08/01 00:01
PMCR- 1988/08/01
CRDT- 1988/08/01 00:00
PHST- 1988/08/01 00:00 [pubmed]
PHST- 1988/08/01 00:01 [medline]
PHST- 1988/08/01 00:00 [entrez]
PHST- 1988/08/01 00:00 [pmc-release]
AID - 10.1128/mcb.8.8.3546-3549.1988 [doi]
PST - ppublish
SO  - Mol Cell Biol. 1988 Aug;8(8):3546-9. doi: 10.1128/mcb.8.8.3546-3549.1988.