PMID- 32650278
OWN - NLM
STAT- MEDLINE
DCOM- 20210709
LR  - 20210709
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 14
IP  - 5
DP  - 2020 Sep-Oct
TI  - Necrotizing soft tissue infection of the upper extremities in patients with 
      diabetes mellitus in a tertiary care center-a retrospective study.
PG  - 1071-1075
LID - S1871-4021(20)30151-X [pii]
LID - 10.1016/j.dsx.2020.05.032 [doi]
AB  - BACKGROUND: Necrotizing soft tissue infection (NSTI) of the upper extremities is 
      a rare, but potentially life-threatening infection in patients with type 2 
      diabetes mellitus (T2DM). We analyzed the clinical characteristics and the 
      outcome of NSTI of upper extremities in these patients. METHODS: This was a 
      retrospective study analyzing the clinical characteristics and the outcomes of 33 
      T2DM patients with NSTI of upper extremities, who were treated in the department 
      of hand surgery between January 2011 and December 2017. RESULTS: Predisposing 
      factors for NSTI were recognized in 16 (48.5%) patients. Eleven (33.3)% patients 
      had septic shock while ten (30.3%) had acute renal insufficiency at the time of 
      presentation, of which six required dialysis. The mean glycosylated hemoglobin 
      was 9.6(+/-2.6)% and the random plasma glucose at admission was 271(+/-96) mg/dl. 
      Monomicrobial infection was seen in 16(49%) patients and polymicrobial infection 
      in 9(27%) patients. Gram-positive causation was found in 25(66%) patients. Twelve 
      (36.4%) patients required amputation, six (18.2%) of which were major. Death 
      occurred in more than one-fifth (21.2%) of the patients during treatment. 
      CONCLUSION: Necrotizing soft tissue infection of the upper extremities in T2DM is 
      associated with increased risk of severe infection, amputation and mortality.
CI  - Copyright (c) 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Naik, Dukhabandhu
AU  - Naik D
AD  - Department of Endocrinology, Diabetes & Metabolism, Christian Medical College, 
      Vellore, 632004, India.
FAU - Jebasingh, Felix K
AU  - Jebasingh FK
AD  - Department of Endocrinology, Diabetes & Metabolism, Christian Medical College, 
      Vellore, 632004, India.
FAU - Thomas, Nihal
AU  - Thomas N
AD  - Department of Endocrinology, Diabetes & Metabolism, Christian Medical College, 
      Vellore, 632004, India.
FAU - Raveendran, Sreekanth
AU  - Raveendran S
AD  - Dr Paul Brand Centre for Hand Surgery, Christian Medical College, Vellore, 
      632004, India. Electronic address: drsreekanthr@gmail.com.
FAU - Raj Pallapati, Samuel C
AU  - Raj Pallapati SC
AD  - Dr Paul Brand Centre for Hand Surgery, Christian Medical College, Vellore, 
      632004, India.
FAU - Prakash, John Jude
AU  - Prakash JJ
AD  - Department of Microbiology, Christian Medical College, Vellore, 632004, India.
FAU - Gowri, Mahasampath
AU  - Gowri M
AD  - Department of Biostatistics, Christian Medical College, Vellore, 632004, India.
FAU - Thomas, Binu Prathap
AU  - Thomas BP
AD  - Dr Paul Brand Centre for Hand Surgery, Christian Medical College, Vellore, 
      632004, India.
LA  - eng
PT  - Journal Article
DEP - 20200528
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Follow-Up Studies
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - India/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Necrosis
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Soft Tissue Infections/epidemiology/microbiology/*pathology
MH  - Tertiary Care Centers/*statistics & numerical data
MH  - Upper Extremity/*microbiology
OTO - NOTNLM
OT  - Amputation
OT  - Diabetes mellitus
OT  - Necrotizing soft tissue infection
OT  - Septic shock
COIS- Declaration of competing interest None of the authors has any conflict of 
      interest to disclose.
EDAT- 2020/07/11 06:00
MHDA- 2021/07/10 06:00
CRDT- 2020/07/11 06:00
PHST- 2019/09/24 00:00 [received]
PHST- 2020/05/14 00:00 [revised]
PHST- 2020/05/16 00:00 [accepted]
PHST- 2020/07/11 06:00 [pubmed]
PHST- 2021/07/10 06:00 [medline]
PHST- 2020/07/11 06:00 [entrez]
AID - S1871-4021(20)30151-X [pii]
AID - 10.1016/j.dsx.2020.05.032 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2020 Sep-Oct;14(5):1071-1075. doi: 
      10.1016/j.dsx.2020.05.032. Epub 2020 May 28.