PMID- 32650426
OWN - NLM
STAT- MEDLINE
DCOM- 20201130
LR  - 20201130
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 17
IP  - 14
DP  - 2020 Jul 8
TI  - Evaluation of the Suitability of an Existing Job-Exposure Matrix for the 
      Assessment of Exposure of UK Biobank Participants to Dust, Fumes, and Diesel 
      Exhaust Particulates.
LID - 10.3390/ijerph17144919 [doi]
LID - 4919
AB  - Many epidemiological studies have shown an association between outdoor 
      particulate air pollutants and increased morbidity and mortality. Inhalation of 
      ambient aerosols can exacerbate or promote the development of cardiovascular and 
      pulmonary diseases as well as other diseases, such as type 2 diabetes mellitus 
      (T2DM) and neurodegenerative diseases. Occupational exposure to dust, fumes and 
      diesel exhaust particulates can also cause adverse health outcomes and there are 
      numerous occupations where workers are exposed to airborne particles that are 
      similar to ambient air pollution. An individual's job title has normally been 
      identified as a major determinant of workplace exposure in epidemiological 
      studies. This has led to the development of Job-Exposure Matrices (JEMs) as a way 
      of characterising specific workplace exposures. One JEM for airborne chemical 
      exposures is the Airborne Chemical Exposure Job-Exposure Matrix (ACE JEM), 
      developed specifically for the UK Biobank cohort. The objective of this paper is 
      to evaluate the suitability of the ACE JEM in assessing occupational aerosol 
      exposure of participants in the UK Biobank. We searched the scientific literature 
      to identify exposure data linked to selected jobs in the ACE JEM and compared 
      these data with the JEM assessments. Additionally, we carried out an independent 
      expert-based assessment of exposure to compare with the JEM estimates. There is 
      good published evidence to substantiate the high dust and biological dust 
      assignments in the JEM and more limited evidence for diesel exhaust particulates. 
      There is limited evidence in the published literature to substantiate moderate or 
      low exposure assignments in the JEM. The independent expert-based assessment 
      found good agreement at the two extremes of exposure in the JEM (high and no 
      exposure), with uncertainty in all other classifications. The ACE JEM assignments 
      are probably reliable for highly exposed jobs and for jobs assigned as unexposed. 
      However, the assignments for medium and low exposures are less reliable. The ACE 
      JEM is likely to be a good tool to examine associations between occupational 
      exposures to particulates and chronic disease, although it should be used with 
      caution. Further efforts should be made to improve the reliability of the ACE 
      JEM.
FAU - Dimakakou, Eirini
AU  - Dimakakou E
AUID- ORCID: 0000-0003-1806-6086
AD  - School of Engineering and Physical Sciences, Institute of Biological Chemistry, 
      Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK.
FAU - Johnston, Helinor J
AU  - Johnston HJ
AD  - School of Engineering and Physical Sciences, Institute of Biological Chemistry, 
      Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK.
FAU - Streftaris, George
AU  - Streftaris G
AD  - Maxwell Institute for Mathematical Sciences, School of Mathematical and Computer 
      Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK.
FAU - Cherrie, John W
AU  - Cherrie JW
AUID- ORCID: 0000-0001-8901-6890
AD  - School of Engineering and Physical Sciences, Institute of Biological Chemistry, 
      Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK.
AD  - Institute of Occupational Medicine (IOM), Edinburgh EH14 4AP, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200708
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Air Pollutants, Occupational)
RN  - 0 (Dust)
RN  - 0 (Vehicle Emissions)
SB  - IM
MH  - *Air Pollutants, Occupational/analysis
MH  - *Biological Specimen Banks
MH  - *Diabetes Mellitus, Type 2
MH  - Dust/analysis
MH  - Humans
MH  - *Occupational Exposure/analysis
MH  - Occupations
MH  - Reproducibility of Results
MH  - Tissue Banks
MH  - United Kingdom/epidemiology
MH  - *Vehicle Emissions/analysis
PMC - PMC7400423
OTO - NOTNLM
OT  - ACE JEM
OT  - JEM
OT  - Job-Exposure Matrix
OT  - UK Biobank
OT  - diesel exhaust particulate
OT  - dust
OT  - epidemiology
OT  - fumes
OT  - occupational exposure
OT  - particulate air pollutants
COIS- The authors declare no conflict of interest.
EDAT- 2020/07/12 06:00
MHDA- 2020/12/01 06:00
PMCR- 2020/07/01
CRDT- 2020/07/12 06:00
PHST- 2020/05/19 00:00 [received]
PHST- 2020/07/02 00:00 [revised]
PHST- 2020/07/03 00:00 [accepted]
PHST- 2020/07/12 06:00 [entrez]
PHST- 2020/07/12 06:00 [pubmed]
PHST- 2020/12/01 06:00 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - ijerph17144919 [pii]
AID - ijerph-17-04919 [pii]
AID - 10.3390/ijerph17144919 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2020 Jul 8;17(14):4919. doi: 
      10.3390/ijerph17144919.