PMID- 32651133 OWN - NLM STAT- MEDLINE DCOM- 20210623 LR - 20210623 IS - 1538-9375 (Electronic) IS - 1525-8610 (Linking) VI - 21 IP - 11 DP - 2020 Nov TI - Erythrocyte Characteristics and the Risk of Depression in Late Life: A Population-Based Prospective Study. PG - 1677-1683 LID - S1525-8610(20)30414-X [pii] LID - 10.1016/j.jamda.2020.05.012 [doi] AB - OBJECTIVES: Inflammation and vascular dysregulation may contribute to the development of depression and impose a burden on erythropoiesis. This study aimed to identify the association of erythrocyte indices with the severity of depressive symptoms and risk of developing depressive disorders in the older people. DESIGN: A prospective cohort study on a randomly sampled Korean older population; the baseline assessment from 2010 to 2012, the first follow-up assessment from 2012 to 2014, and the second follow-up assessment from 2014 to 2016 (mean follow-up duration = 3.4 years). SETTING: A nationwide and community-based cohort. PARTICIPANTS: A total of 4451 Koreans aged 60 years or older. METHODS: We examined the associations of the values and changes in mean corpuscular volume, mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) with the risk of prevalent and incident depression using logistic regression analyses. RESULTS: High MCH and MCHC in female participants and high MCHC in male participants were associated with high geriatric depression scale scores and risk of prevalent depression. In female participants, high- and middle-MCH tertile groups showed a 2.68- and 2.34-fold higher risk of incident depression than did the low tertile group. In male participants, the high-MCH tertile group showed a 1.79-fold higher risk of incident depression than did the low tertile group. In both sexes, the participants whose MCV changed to the high or middle tertile or remained in the high or middle tertile during the follow-up period, and whose MCH increased to the high tertile or remained in the high tertile, were at a higher risk of incident depression. CONCLUSIONS AND IMPLICATIONS: Changes in erythrocyte may be associated with the risk of depression in older adults. This prospective study proposes a new perspective of the old hematologic parameters for understanding the pathophysiology of late-life depression. CI - Copyright (c) 2020 AMDA - The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved. FAU - Oh, Dae Jong AU - Oh DJ AD - Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggido, Korea; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea. FAU - Han, Ji Won AU - Han JW AD - Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggido, Korea. FAU - Bae, Jong Bin AU - Bae JB AD - Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggido, Korea. FAU - Kim, Hye Sung AU - Kim HS AD - Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggido, Korea. FAU - Suh, Seung Wan AU - Suh SW AD - Department of Psychiatry, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. FAU - Byun, Seonjeong AU - Byun S AD - Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea; Department of Neuropsychiatry, National Medical Center, Seoul, Korea. FAU - Kim, Tae Hui AU - Kim TH AD - Department of Psychiatry, Yonsei University Wonju Severance Christian Hospital, Wonju, Korea. FAU - Kwak, Kyung Phil AU - Kwak KP AD - Department of Psychiatry, Dongguk University Gyeongju Hospital, Gyeongju, Korea. FAU - Kim, Bong Jo AU - Kim BJ AD - Department of Psychiatry, Gyeongsang National University School of Medicine, Jinju, Korea. FAU - Kim, Shin Gyeom AU - Kim SG AD - Department of Neuropsychiatry, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. FAU - Kim, Jeong Lan AU - Kim JL AD - Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, Korea. FAU - Moon, Seok Woo AU - Moon SW AD - Department of Psychiatry, School of Medicine, Konkuk University, Konkuk University Chungju Hospital, Chungju, Korea. FAU - Park, Joon Hyuk AU - Park JH AD - Department of Neuropsychiatry, Jeju National University Hospital, Jeju, Korea. FAU - Ryu, Seung-Ho AU - Ryu SH AD - Department of Psychiatry, School of Medicine, Konkuk University, Konkuk University Medical Center, Seoul, Korea. FAU - Youn, Jong Chul AU - Youn JC AD - Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Yongin, Korea. FAU - Lee, Dong Young AU - Lee DY AD - Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggido, Korea; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea. FAU - Lee, Dong Woo AU - Lee DW AD - Department of Neuropsychiatry, Inje University Sanggye Paik Hospital, Seoul, Korea. FAU - Lee, Seok Bum AU - Lee SB AD - Department of Psychiatry, Dankook University Hospital, Cheonan, Korea. FAU - Lee, Jung Jae AU - Lee JJ AD - Department of Psychiatry, Dankook University Hospital, Cheonan, Korea. FAU - Jhoo, Jin Hyeong AU - Jhoo JH AD - Department of Psychiatry, Kangwon National University School of Medicine, Chuncheon, Korea. FAU - Kim, Ki Woong AU - Kim KW AD - Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggido, Korea; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea; Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences, Seoul, Korea. Electronic address: kwkimmd@snu.ac.kr. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200707 PL - United States TA - J Am Med Dir Assoc JT - Journal of the American Medical Directors Association JID - 100893243 SB - IM MH - Aged MH - *Depression/epidemiology MH - *Erythrocyte Indices MH - Erythrocytes MH - Female MH - Humans MH - Male MH - Prospective Studies OTO - NOTNLM OT - Depression OT - biomarker OT - erythrocyte index OT - erythropoiesis OT - geriatric psychiatry OT - late life depression EDAT- 2020/07/12 06:00 MHDA- 2021/06/24 06:00 CRDT- 2020/07/12 06:00 PHST- 2019/10/18 00:00 [received] PHST- 2020/02/12 00:00 [revised] PHST- 2020/05/09 00:00 [accepted] PHST- 2020/07/12 06:00 [pubmed] PHST- 2021/06/24 06:00 [medline] PHST- 2020/07/12 06:00 [entrez] AID - S1525-8610(20)30414-X [pii] AID - 10.1016/j.jamda.2020.05.012 [doi] PST - ppublish SO - J Am Med Dir Assoc. 2020 Nov;21(11):1677-1683. doi: 10.1016/j.jamda.2020.05.012. Epub 2020 Jul 7.