PMID- 32652957
OWN - NLM
STAT- MEDLINE
DCOM- 20201019
LR  - 20240329
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Jul 11
TI  - LSVT-BIG therapy in Parkinson's disease: physiological evidence for 
      proprioceptive recalibration.
PG  - 276
LID - 10.1186/s12883-020-01858-2 [doi]
LID - 276
AB  - BACKGROUND: There is growing evidence for proprioceptive dysfunction in patients 
      with Parkinson's disease (PD). The Lee Silvermann Voice Treatment-BIG therapy 
      (LSVT-BIG), a special training program aiming at an increase of movement 
      amplitudes in persons with PD (PwPD), has shown to be effective on motor 
      symptoms. LSVT-BIG is conceptionally based on improving bradykinesia, in 
      particular the decrement of repetitive movements, by proprioceptive 
      recalibration. OBJECTIVE: To assess proprioceptive impairment in PwPD as compared 
      to matched controls and to probe potential recalibration effects of the LSVT-BIG 
      therapy on proprioception. METHODS: Proprioceptive performance and fine motor 
      skills were assessed in 30 PwPD and 15 matched controls. Measurements with 
      significant impairment in PwPD were chosen as outcome parameters for a 
      standardized 4 weeks amplitude-based training intervention (LSVT-BIG) in 11 PwPD. 
      Proprioceptive performance served as primary outcome measure. Secondary outcome 
      measures included the motor part of the MDS-UPDRS, the nine-hole-peg test, and a 
      questionnaire on quality of life. Post-interventional assessments were conducted 
      at weeks 4 and 8. RESULTS: Compared to the control group, PwPD showed 
      significantly larger pointing errors. After 4 weeks of LSVT-BIG therapy and even 
      more so after an additional 4 weeks of continued training, proprioceptive 
      performance improved significantly. In addition, quality of life improved as 
      indicated by a questionnaire. CONCLUSION: LSVT-BIG training may achieve a 
      recalibration of proprioceptive processing in PwPD. Our data indicates a probable 
      physiological mechanism of a symptom-specific, amplitude-based behavioral 
      intervention in PwPD.
FAU - Peterka, Manuel
AU  - Peterka M
AUID- ORCID: 0000-0002-4618-9115
AD  - Department of Neurology, University of Wurzburg, Josef-Schneider-Str. 11, 97080, 
      Wurzburg, Germany. manuelpeterka@gmx.net.
FAU - Odorfer, Thorsten
AU  - Odorfer T
AD  - Department of Neurology, University of Wurzburg, Josef-Schneider-Str. 11, 97080, 
      Wurzburg, Germany.
FAU - Schwab, Michael
AU  - Schwab M
AD  - Stiftung Burgerspital zum Hl. Geist, 97070, Wurzburg, Germany.
FAU - Volkmann, Jens
AU  - Volkmann J
AD  - Department of Neurology, University of Wurzburg, Josef-Schneider-Str. 11, 97080, 
      Wurzburg, Germany.
FAU - Zeller, Daniel
AU  - Zeller D
AD  - Department of Neurology, University of Wurzburg, Josef-Schneider-Str. 11, 97080, 
      Wurzburg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20200711
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
SB  - IM
MH  - Aged
MH  - *Exercise Therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*therapy
MH  - Proprioception/*physiology
MH  - Quality of Life
PMC - PMC7353788
OTO - NOTNLM
OT  - Amplitude
OT  - LSVT-big therapy
OT  - Pointing error
OT  - Proprioception
OT  - Training
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2020/07/13 06:00
MHDA- 2020/10/21 06:00
PMCR- 2020/07/11
CRDT- 2020/07/13 06:00
PHST- 2020/04/13 00:00 [received]
PHST- 2020/07/07 00:00 [accepted]
PHST- 2020/07/13 06:00 [entrez]
PHST- 2020/07/13 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2020/07/11 00:00 [pmc-release]
AID - 10.1186/s12883-020-01858-2 [pii]
AID - 1858 [pii]
AID - 10.1186/s12883-020-01858-2 [doi]
PST - epublish
SO  - BMC Neurol. 2020 Jul 11;20(1):276. doi: 10.1186/s12883-020-01858-2.