PMID- 32652980
OWN - NLM
STAT- MEDLINE
DCOM- 20201229
LR  - 20220531
IS  - 1472-6831 (Electronic)
IS  - 1472-6831 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Jul 11
TI  - Epidemiologic relationship between periodontitis and type 2 diabetes mellitus.
PG  - 204
LID - 10.1186/s12903-020-01180-w [doi]
LID - 204
AB  - BACKGROUND: To systematically review the epidemiologic relationship between 
      periodontitis and type 2 diabetes mellitus (T2DM). METHODS: Four electronic 
      databases were searched up until December 2018. The manual search included the 
      reference lists of the included studies and relevant journals. Observational 
      studies evaluating the relationship between T2DM and periodontitis were included. 
      Meta-analyses were conducted using STATA. RESULTS: A total of 53 observational 
      studies were included. The Adjusted T2DM prevalence was significantly higher in 
      periodontitis patients (OR = 4.04, p = 0.000), and vice versa (OR = 1.58, 
      p = 0.000). T2DM patients had significantly worse periodontal status, as 
      reflected in a 0.61 mm deeper periodontal pocket, a 0.89 mm higher attachment 
      loss and approximately 2 more lost teeth (all p = 0.000), than those without 
      T2DM. The results of the cohort studies found that T2DM could elevate the risk of 
      developing periodontitis by 34% (p = 0.002). The glycemic control of T2DM 
      patients might result in different periodontitis outcomes. Severe periodontitis 
      increased the incidence of T2DM by 53% (p = 0.000), and this result was stable. 
      In contrast, the impact of mild periodontitis on T2DM incidence (RR = 1.28, 
      p = 0.007) was less robust. CONCLUSIONS: There is an evident bidirectional 
      relationship between T2DM and periodontitis. Further well-designed cohort studies 
      are needed to confirm this finding. Our results suggest that both dentists and 
      physicians need to be aware of the strong connection between periodontitis and 
      T2DM. Controlling these two diseases might help prevent each other's incidence.
FAU - Wu, Chen-Zhou
AU  - Wu CZ
AD  - State Key Laboratory of Oral Diseases & National Clinical Research Center for 
      Oral Diseases & Department of Head and Neck Oncology, West China Hospital of 
      Stomatology, Sichuan University, Number 14, Unit 3, Renmin Nan Road, Chengdu 
      City, 610041, Sichuan, China.
FAU - Yuan, Yi-Hang
AU  - Yuan YH
AD  - State Key Laboratory of Oral Diseases & National Clinical Research Center for 
      Oral Diseases & Department of Head and Neck Oncology, West China Hospital of 
      Stomatology, Sichuan University, Number 14, Unit 3, Renmin Nan Road, Chengdu 
      City, 610041, Sichuan, China.
FAU - Liu, Hang-Hang
AU  - Liu HH
AD  - State Key Laboratory of Oral Diseases & National Clinical Research Center for 
      Oral Diseases & Department of Orthognathic and Temporomandibular Joint Surgery, 
      West China Hospital of Stomatology, Sichuan University, Chengdu, China.
FAU - Li, Shen-Sui
AU  - Li SS
AD  - State Key Laboratory of Oral Diseases & National Clinical Research Center for 
      Oral Diseases & Department of Head and Neck Oncology, West China Hospital of 
      Stomatology, Sichuan University, Number 14, Unit 3, Renmin Nan Road, Chengdu 
      City, 610041, Sichuan, China.
FAU - Zhang, Bo-Wen
AU  - Zhang BW
AD  - State Key Laboratory of Oral Diseases & National Clinical Research Center for 
      Oral Diseases & Department of Head and Neck Oncology, West China Hospital of 
      Stomatology, Sichuan University, Number 14, Unit 3, Renmin Nan Road, Chengdu 
      City, 610041, Sichuan, China.
FAU - Chen, Wen
AU  - Chen W
AD  - State Key Laboratory of Oral Diseases & National Clinical Research Center for 
      Oral Diseases & Department of Head and Neck Oncology, West China Hospital of 
      Stomatology, Sichuan University, Number 14, Unit 3, Renmin Nan Road, Chengdu 
      City, 610041, Sichuan, China.
FAU - An, Zi-Jian
AU  - An ZJ
AD  - State Key Laboratory of Oral Diseases & National Clinical Research Center for 
      Oral Diseases & Department of Head and Neck Oncology, West China Hospital of 
      Stomatology, Sichuan University, Number 14, Unit 3, Renmin Nan Road, Chengdu 
      City, 610041, Sichuan, China.
FAU - Chen, Si-Yu
AU  - Chen SY
AD  - State Key Laboratory of Oral Diseases & National Clinical Research Center for 
      Oral Diseases & Department of Head and Neck Oncology, West China Hospital of 
      Stomatology, Sichuan University, Number 14, Unit 3, Renmin Nan Road, Chengdu 
      City, 610041, Sichuan, China.
FAU - Wu, Yong-Zhi
AU  - Wu YZ
AD  - State Key Laboratory of Oral Diseases & National Clinical Research Center for 
      Oral Diseases & Department of Head and Neck Oncology, West China Hospital of 
      Stomatology, Sichuan University, Number 14, Unit 3, Renmin Nan Road, Chengdu 
      City, 610041, Sichuan, China.
FAU - Han, Bo
AU  - Han B
AD  - State Key Laboratory of Oral Diseases & National Clinical Research Center for 
      Oral Diseases & Department of Head and Neck Oncology, West China Hospital of 
      Stomatology, Sichuan University, Number 14, Unit 3, Renmin Nan Road, Chengdu 
      City, 610041, Sichuan, China.
FAU - Li, Chun-Jie
AU  - Li CJ
AD  - State Key Laboratory of Oral Diseases & National Clinical Research Center for 
      Oral Diseases & Department of Head and Neck Oncology, West China Hospital of 
      Stomatology, Sichuan University, Number 14, Unit 3, Renmin Nan Road, Chengdu 
      City, 610041, Sichuan, China.
FAU - Li, Long-Jiang
AU  - Li LJ
AD  - State Key Laboratory of Oral Diseases & National Clinical Research Center for 
      Oral Diseases & Department of Head and Neck Oncology, West China Hospital of 
      Stomatology, Sichuan University, Number 14, Unit 3, Renmin Nan Road, Chengdu 
      City, 610041, Sichuan, China. lilongjiang63@163.com.
LA  - eng
GR  - 81972538/National Nature Science Foundation of China/International
GR  - 2016SZ0063/Key Technology R&D Program of Sichuan Province of 
      China/International
GR  - 2018YJSY106/Graduate Student's Research and Innovation Fund of Sichuan 
      University/International
GR  - 81672669/National Nature Science Foundation of China/International
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20200711
PL  - England
TA  - BMC Oral Health
JT  - BMC oral health
JID - 101088684
SB  - IM
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Humans
MH  - Periodontal Pocket
MH  - *Periodontitis/complications/epidemiology
PMC - PMC7353775
OTO - NOTNLM
OT  - Diabetes mellitus, type 2
OT  - Epidemiologic studies
OT  - Meta-analysis
OT  - Periodontitis
OT  - Systematic review
COIS- The authors declare that they have no competing interests.
EDAT- 2020/07/13 06:00
MHDA- 2020/12/30 06:00
PMCR- 2020/07/11
CRDT- 2020/07/13 06:00
PHST- 2019/05/09 00:00 [received]
PHST- 2020/06/29 00:00 [accepted]
PHST- 2020/07/13 06:00 [entrez]
PHST- 2020/07/13 06:00 [pubmed]
PHST- 2020/12/30 06:00 [medline]
PHST- 2020/07/11 00:00 [pmc-release]
AID - 10.1186/s12903-020-01180-w [pii]
AID - 1180 [pii]
AID - 10.1186/s12903-020-01180-w [doi]
PST - epublish
SO  - BMC Oral Health. 2020 Jul 11;20(1):204. doi: 10.1186/s12903-020-01180-w.