PMID- 32653093
OWN - NLM
STAT- MEDLINE
DCOM- 20210917
LR  - 20210917
IS  - 1958-5578 (Electronic)
IS  - 0040-5957 (Linking)
VI  - 75
IP  - 6
DP  - 2020 Nov-Dec
TI  - [Summary of the recommendations of the International Association of Therapeutic 
      Drug Monitoring and Clinical Toxicology (IATDMCT) on the therapeutic drug 
      monitoring of tacrolimus].
PG  - 681-685
LID - S0040-5957(20)30108-6 [pii]
LID - 10.1016/j.therap.2020.06.004 [doi]
AB  - Recently, the International Association of Therapeutic Drug Monitoring (IATDMCT), 
      that is the learning society for biological pharmacology and toxicology, issued 
      recommendations on the therapeutic drug monitoring (TDM) of tacrolimus. This is 
      the second consensus after the one issued in 2009. In this document, the role of 
      tacrolimus TDM for the four principal transplanted organs is discussed. The 
      analytical aspects, pharmacogenetics, TDM alternative approaches and the 
      positioning of biomarkers are also presented. Stronger recommendations are about 
      trough concentration targets in kidney and liver transplantation and for other 
      indication of tacrolimus use. For the first time, an area under the curve of 
      tacrolimus concentrations target is recommended for recipients management. 
      Eventually, another set of recommendations are proposed for pharmacodynamic 
      biomarkers used in patients' follow-up.
CI  - Copyright (c) 2020 Societe francaise de pharmacologie et de therapeutique. 
      Published by Elsevier Masson SAS. All rights reserved.
FAU - Lemaitre, Florian
AU  - Lemaitre F
AD  - Inserm, EHESP, institut de recherche en sante, environnement et travail 
      (Irset) - UMRS 1085, universite Rennes, CHU Rennes, 35000 Rennes, France; Inserm, 
      centre d'investigation clinique 1414, 35000 Rennes, France. Electronic address: 
      florian.lemaitre@chu-rennes.fr.
FAU - Monchaud, Caroline
AU  - Monchaud C
AD  - Service de pharmacologie, toxicologie et pharmacovigilance, CHU Limoges, 87000 
      Limoges, France; Inserm, UMR-1248, 87000 Limoges, France.
FAU - Woillard, Jean-Baptiste
AU  - Woillard JB
AD  - Service de pharmacologie, toxicologie et pharmacovigilance, CHU Limoges, 87000 
      Limoges, France; Inserm, UMR-1248, 87000 Limoges, France; Faculte de medicine, 
      univeriste Limoges, 87000 Limoges, France.
FAU - Picard, Nicolas
AU  - Picard N
AD  - Service de pharmacologie, toxicologie et pharmacovigilance, CHU Limoges, 87000 
      Limoges, France; Inserm, UMR-1248, 87000 Limoges, France; Faculte de medicine, 
      univeriste Limoges, 87000 Limoges, France.
FAU - Marquet, Pierre
AU  - Marquet P
AD  - Service de pharmacologie, toxicologie et pharmacovigilance, CHU Limoges, 87000 
      Limoges, France; Inserm, UMR-1248, 87000 Limoges, France; Faculte de medicine, 
      univeriste Limoges, 87000 Limoges, France.
LA  - fre
PT  - Journal Article
TT  - Synthese des recommandations de l'International Association of Therapeutic Drug 
      Monitoring and Clinical Toxicology (IATDMCT) sur le suivi therapeutique 
      pharmacologique du tacrolimus.
DEP - 20200620
PL  - France
TA  - Therapie
JT  - Therapie
JID - 0420544
RN  - 0 (Immunosuppressive Agents)
RN  - WM0HAQ4WNM (Tacrolimus)
SB  - IM
MH  - *Drug Monitoring
MH  - Graft Rejection/prevention & control
MH  - Humans
MH  - Immunosuppressive Agents/adverse effects
MH  - Pharmacogenetics
MH  - *Tacrolimus/adverse effects
OTO - NOTNLM
OT  - Adverse events
OT  - Calcineurin inhibitors
OT  - Effets indesirables
OT  - Inhibiteur de calcineurine
OT  - Pharmacocinetique
OT  - Pharmacokinetics
OT  - Rejection
OT  - Rejet
OT  - Transplantation
EDAT- 2020/07/13 06:00
MHDA- 2021/09/18 06:00
CRDT- 2020/07/13 06:00
PHST- 2020/02/11 00:00 [received]
PHST- 2020/04/20 00:00 [revised]
PHST- 2020/06/15 00:00 [accepted]
PHST- 2020/07/13 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2020/07/13 06:00 [entrez]
AID - S0040-5957(20)30108-6 [pii]
AID - 10.1016/j.therap.2020.06.004 [doi]
PST - ppublish
SO  - Therapie. 2020 Nov-Dec;75(6):681-685. doi: 10.1016/j.therap.2020.06.004. Epub 
      2020 Jun 20.