PMID- 32653734
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20231115
IS  - 2211-0356 (Electronic)
IS  - 2211-0348 (Linking)
VI  - 45
DP  - 2020 Oct
TI  - Neutrophil-to-lymphocyte ratio correlates with disease activity in myelin 
      oligodendrocyte glycoprotein antibody associated disease (MOGAD) in children.
PG  - 102345
LID - S2211-0348(20)30420-X [pii]
LID - 10.1016/j.msard.2020.102345 [doi]
AB  - The neutrophil-to-lymphocyte ratio (NLR) was shown correlate with disease 
      activity in systemic autoimmunity and MS. In a cohort of 62 children with 
      demyelinating diseases; NLR was high both acutely (P<.001) and during remission 
      (P=.01) in AQP4-Ab NMOSD; higher only at time of clinical attack (P<.001) but not 
      at time of remission in MOGAD and not different to that of controls neither 
      during relapse nor remission in MS. The temporal correlation of NLR with MOGAD 
      activity could be used as a supportive biomarker for acute relapse, given that 
      the clinical differentiation between relapses and pseudo-relapses can be 
      challenging.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Benetou, Christina
AU  - Benetou C
AD  - Department of Children's Neurosciences, Evelina London Children's Hospital, Guys 
      and St. Thomas' Hospital NHS Foundation Trust, Kings Health Partners, London, UK.
FAU - Berti, Francesco
AU  - Berti F
AD  - Department of Paediatric Neurology, Great Ormond Street Hospital for Children, 
      London, UK.
FAU - Hemingway, Cheryl
AU  - Hemingway C
AD  - Department of Paediatric Neurology, Great Ormond Street Hospital for Children, 
      London, UK.
FAU - Hacohen, Yael
AU  - Hacohen Y
AD  - Department of Paediatric Neurology, Great Ormond Street Hospital for Children, 
      London, UK; Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain 
      Sciences, University College London, London, UK.
FAU - Lim, Ming
AU  - Lim M
AD  - Department of Children's Neurosciences, Evelina London Children's Hospital, Guys 
      and St. Thomas' Hospital NHS Foundation Trust, Kings Health Partners, London, UK; 
      School of Life Course Sciences, Facultly of Life Sciences and Medicine, King's 
      College London, London, UK. Electronic address: ming.lim@gstt.nhs.uk.
LA  - eng
GR  - MR/T024437/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20200630
PL  - Netherlands
TA  - Mult Scler Relat Disord
JT  - Multiple sclerosis and related disorders
JID - 101580247
RN  - 0 (Aquaporin 4)
RN  - 0 (Autoantibodies)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
SB  - IM
MH  - Aquaporin 4
MH  - Autoantibodies
MH  - Child
MH  - Humans
MH  - Lymphocytes
MH  - Myelin-Oligodendrocyte Glycoprotein
MH  - *Neuromyelitis Optica
MH  - Neutrophils
OTO - NOTNLM
OT  - Acquired demyelinating syndromes (ADS)
OT  - Aquaporin-4 antibody neuromyelitis optica spectrum disorder (NMOSD)
OT  - Multiple sclerosis (MS)
OT  - Myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD)
OT  - Neutrophil-to-lymphocyte ratio (NLR)
EDAT- 2020/07/13 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/07/13 06:00
PHST- 2020/06/08 00:00 [received]
PHST- 2020/06/27 00:00 [revised]
PHST- 2020/06/29 00:00 [accepted]
PHST- 2020/07/13 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/07/13 06:00 [entrez]
AID - S2211-0348(20)30420-X [pii]
AID - 10.1016/j.msard.2020.102345 [doi]
PST - ppublish
SO  - Mult Scler Relat Disord. 2020 Oct;45:102345. doi: 10.1016/j.msard.2020.102345. 
      Epub 2020 Jun 30.