PMID- 32654677 OWN - NLM STAT- MEDLINE DCOM- 20211027 LR - 20211027 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 24 IP - 12 DP - 2021 Aug TI - The association of urine markers of iodine intake with development and growth among children in rural Uganda: a secondary analysis of a randomised education trial. PG - 3730-3739 LID - 10.1017/S1368980020001603 [doi] AB - OBJECTIVE: We examined associations of urine iodide excretion, proxy for iodine intake, with child development and growth. DESIGN: This is a secondary analysis of a 1:1 cluster-randomised trial with a 6-month nutrition/stimulation/hygiene education intervention among mothers of children aged 6-8 months to improve child development and growth. Development was assessed using Bayley Scales of Infant and Toddler Development-III (BSID-III) and Ages and Stages Questionnaire (ASQ), whereas anthropometry was used to assess growth. Urine iodide concentration (UIC) and urine iodide/creatinine ratio (ICR) were measured. SETTING: The current study was conducted in southern Uganda. PARTICIPANTS: We randomly selected 155 children from the 511 enrolled into the original trial and analysed data when they were aged 20-24 and 36 months. RESULTS: Median UIC for both study groups at 20-24 and 36 months were similar (P > 0.05) and within the normal range of 100-199 microg/l (0.79-1.60 micromol/l), whereas the intervention group had significantly higher ICR at 20-24 months. The BSID-III cognitive score was positively associated (P = 0.028) with ICR at 20-24 months in the intervention group. The ASQ gross motor score was negatively associated (P = 0.020) with ICR at 20-24 months among the controls. ICR was not significantly associated with anthropometry in the two study groups at either time-point. CONCLUSIONS: Following the intervention, a positive association was noted between ICR and child's cognitive score at 20-24 months, whereas no positive association with ICR and growth was detected. Iodine sufficiency may be important for child's cognitive development in this setting. FAU - Atukunda, Prudence AU - Atukunda P AD - Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 0317Oslo, Norway. FAU - Muhoozi, Grace Km AU - Muhoozi GK AD - Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 0317Oslo, Norway. AD - Department of Human Nutrition and Home Economics, Kyambogo University, Kampala, Uganda. FAU - Diep, Lien M AU - Diep LM AD - Oslo Center for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway. FAU - Berg, Jens P AU - Berg JP AD - Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway. AD - Institute of Clinical Medicine, University of Oslo, Oslo, Norway. FAU - Westerberg, Ane C AU - Westerberg AC AD - Institute of Health Sciences, Kristiania University College, Oslo, Norway. FAU - Iversen, Per O AU - Iversen PO AD - Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 0317Oslo, Norway. AD - Department of Haematology, Oslo University Hospital, Oslo, Norway. AD - Division of Human Nutrition, Stellenbosch University, Tygerberg, South Africa. LA - eng SI - ClinicalTrials.gov/NCT02098031 PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200713 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 RN - 9679TC07X4 (Iodine) SB - IM MH - *Child Development MH - Female MH - Humans MH - Infant MH - *Iodine MH - Mothers MH - Rural Population MH - Uganda PMC - PMC8369454 OTO - NOTNLM OT - Child development OT - Education OT - Growth OT - Iodide OT - Mothers OT - Nutrition OT - Uganda EDAT- 2020/07/14 06:00 MHDA- 2021/10/28 06:00 PMCR- 2021/08/17 CRDT- 2020/07/14 06:00 PHST- 2020/07/14 06:00 [pubmed] PHST- 2021/10/28 06:00 [medline] PHST- 2020/07/14 06:00 [entrez] PHST- 2021/08/17 00:00 [pmc-release] AID - S1368980020001603 [pii] AID - 10.1017/S1368980020001603 [doi] PST - ppublish SO - Public Health Nutr. 2021 Aug;24(12):3730-3739. doi: 10.1017/S1368980020001603. Epub 2020 Jul 13.