PMID- 32656171
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 8
DP  - 2020
TI  - The rs1051931 G>A Polymorphism in the PLA2G7 Gene Confers Resistance to 
      Immunoglobulin Therapy in Kawasaki Disease in a Southern Chinese Population.
PG  - 338
LID - 10.3389/fped.2020.00338 [doi]
LID - 338
AB  - Background: Kawasaki disease (KD) is a common cardiovascular disease in infants 
      and young children, with fever, rash, and conjunctivitis as the main clinical 
      manifestations, which can lead to the occurrence of coronary aneurysms. 
      Intravenous immunoglobulin (IVIG) is the preferred treatment for KD patients, but 
      10-20% of patients are resistant to IVIG. Lipoprotein-associated phospholipase A 
      2 (Lp-PLA2) is a potential therapeutic target for coronary atherosclerotic heart 
      disease, and the polymorphism of Phospholipase A2 Group VII (PLA2G7) is closely 
      related to the activity of Lp-PLA2, of which rs1051931 is the strongest. 
      Therefore, the rs1051931 polymorphism may be a predictor of IVIG resistance in KD 
      patients. Methods: A total of 760 KD cases, including 148 IVIG-resistant patients 
      and 612 IVIG-responsive patients, were genotyped for rs1051931 in PLA2G7, we 
      compared the effects of rs1051931 on IVIG treatment in KD patients by odds ratios 
      (OR) and 95% confidence interval (CI). Results: The homozygous mutation AA may be 
      a protective factor for IVIG resistance in KD patients (adjusted OR = 3.47, 95% 
      CI = 1.14-10.57, P = 0.0284) and is more evident in patients with KD aged <60 
      months (adjusted OR = 3.68, 95% CI = 1.10-12.28, P = 0.0399). Conclusions: The 
      PLA2G7 rs1051931 G>A polymorphism may be suitable as a biomarker for the 
      diagnosis or prognosis of IVIG resistance in KD in a southern Chinese population.
CI  - Copyright (c) 2020 Gu, Lin, Xu, Che, Tan, Lu, Pi, Fu, Zhou, Jiang and Gu.
FAU - Gu, Xueping
AU  - Gu X
AD  - Department of Blood Transfusion and Clinical Lab, Guangzhou Women and Children's 
      Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, 
      Guangzhou, China.
FAU - Lin, Wenchun
AU  - Lin W
AD  - Department of Pneumology, Guangzhou Women and Children's Medical Center, 
      Guangzhou Medical College, Guangzhou, China.
FAU - Xu, Yufen
AU  - Xu Y
AD  - Department of Clinical Biological Resource Bank, Guangzhou Women and Children's 
      Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, 
      Guangzhou, China.
FAU - Che, Di
AU  - Che D
AD  - Department of Clinical Biological Resource Bank, Guangzhou Women and Children's 
      Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, 
      Guangzhou, China.
FAU - Tan, Yaqian
AU  - Tan Y
AD  - Department of Clinical Biological Resource Bank, Guangzhou Women and Children's 
      Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, 
      Guangzhou, China.
FAU - Lu, Zhaoliang
AU  - Lu Z
AD  - Department of Clinical Biological Resource Bank, Guangzhou Women and Children's 
      Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, 
      Guangzhou, China.
FAU - Pi, Lei
AU  - Pi L
AD  - Department of Clinical Biological Resource Bank, Guangzhou Women and Children's 
      Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, 
      Guangzhou, China.
FAU - Fu, Lanyan
AU  - Fu L
AD  - Department of Clinical Biological Resource Bank, Guangzhou Women and Children's 
      Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, 
      Guangzhou, China.
FAU - Zhou, Huazhong
AU  - Zhou H
AD  - Department of Clinical Biological Resource Bank, Guangzhou Women and Children's 
      Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, 
      Guangzhou, China.
FAU - Jiang, Zhiyong
AU  - Jiang Z
AD  - Department of Blood Transfusion and Clinical Lab, Guangzhou Women and Children's 
      Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, 
      Guangzhou, China.
FAU - Gu, Xiaoqiong
AU  - Gu X
AD  - Department of Blood Transfusion and Clinical Lab, Guangzhou Women and Children's 
      Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, 
      Guangzhou, China.
AD  - Department of Clinical Biological Resource Bank, Guangzhou Women and Children's 
      Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, 
      Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20200623
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC7324548
OTO - NOTNLM
OT  - Kawasaki disease
OT  - PLA2G7
OT  - immunoglobulin therapy
OT  - polymorphism
OT  - rs1051931
EDAT- 2020/07/14 06:00
MHDA- 2020/07/14 06:01
PMCR- 2020/06/23
CRDT- 2020/07/14 06:00
PHST- 2019/08/14 00:00 [received]
PHST- 2020/05/21 00:00 [accepted]
PHST- 2020/07/14 06:00 [entrez]
PHST- 2020/07/14 06:00 [pubmed]
PHST- 2020/07/14 06:01 [medline]
PHST- 2020/06/23 00:00 [pmc-release]
AID - 10.3389/fped.2020.00338 [doi]
PST - epublish
SO  - Front Pediatr. 2020 Jun 23;8:338. doi: 10.3389/fped.2020.00338. eCollection 2020.