PMID- 32656253
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2297-1769 (Print)
IS  - 2297-1769 (Electronic)
IS  - 2297-1769 (Linking)
VI  - 7
DP  - 2020
TI  - Circulating Methemoblogin Fraction in Dogs With Sepsis.
PG  - 341
LID - 10.3389/fvets.2020.00341 [doi]
LID - 341
AB  - Large amount of nitric oxide (NO) can be released in patients with sepsis. 
      Methemoglobin is formed from the interaction between NO and hemoglobin. Mild 
      methemoglobinemia reflecting NO overproduction has been reported in septic 
      people, and occasionally associated to septic shock and organ dysfunction. The 
      aim of this retrospective study was to evaluate circulating methemoglobin 
      fraction in dogs with sepsis and to assess its prognostic value. Methemoglobin 
      reference interval (RI) was calculated in 41 healthy dogs and was set at 0-2.2%. 
      A total of 131 dogs with sepsis were included in the study; 24/131 had a 
      circulating methemoglobin >/=2.2%. The median methemoglobin fraction was 
      significantly higher in dogs with sepsis compared to healthy ones (1.7%, 0.4-3.5% 
      vs. 1.0, 0.3-2.2%, P = 0.0005). No significant difference was observed between 
      dogs with uncomplicated sepsis (n = 98) vs. dogs with septic shock (n = 33) 
      (1.8%, 0.4-2.8% vs. 1.5%, 0.4-3.5%, P = 0.74), between dogs with and without 
      multi-organ dysfunction (n = 38 and n = 93, respectively) (1.7%, 0.4-3.5% vs. 
      1.7%, 0.5-2.8%, P = 0.27), and between survivors (n = 77) vs. non survivors (n = 
      54) (1.5%, 0.4-2.8% vs. 1.8%, 0.4-3.5%, P = 0.05). Dogs with methemoglobin 
      fraction above or equal to the upper limit of the RI had a significantly higher 
      frequency of death compared to dogs with methemoglobin levels <2.2% (60.0% vs. 
      36.8%, P = 0.04). In conclusion, mild methemoglobinemia is detected in dogs with 
      sepsis, and methemoglobin values above the RI might be associated with a worse 
      outcome.
CI  - Copyright (c) 2020 Troia, Ciuffoli, Vasylyeva, Foglia, Dondi and Giunti.
FAU - Troia, Roberta
AU  - Troia R
AD  - Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of 
      Bologna, Bologna, Italy.
FAU - Ciuffoli, Elena
AU  - Ciuffoli E
AD  - Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of 
      Bologna, Bologna, Italy.
FAU - Vasylyeva, Kateryna
AU  - Vasylyeva K
AD  - Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of 
      Bologna, Bologna, Italy.
FAU - Foglia, Armando
AU  - Foglia A
AD  - Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of 
      Bologna, Bologna, Italy.
FAU - Dondi, Francesco
AU  - Dondi F
AD  - Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of 
      Bologna, Bologna, Italy.
FAU - Giunti, Massimo
AU  - Giunti M
AD  - Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of 
      Bologna, Bologna, Italy.
LA  - eng
PT  - Journal Article
DEP - 20200616
PL  - Switzerland
TA  - Front Vet Sci
JT  - Frontiers in veterinary science
JID - 101666658
PMC - PMC7326004
OTO - NOTNLM
OT  - CO-oximetry
OT  - canine
OT  - methemoglobin
OT  - nitric oxide
OT  - sepsis
OT  - septic shock
EDAT- 2020/07/14 06:00
MHDA- 2020/07/14 06:01
PMCR- 2020/01/01
CRDT- 2020/07/14 06:00
PHST- 2020/02/18 00:00 [received]
PHST- 2020/05/15 00:00 [accepted]
PHST- 2020/07/14 06:00 [entrez]
PHST- 2020/07/14 06:00 [pubmed]
PHST- 2020/07/14 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fvets.2020.00341 [doi]
PST - epublish
SO  - Front Vet Sci. 2020 Jun 16;7:341. doi: 10.3389/fvets.2020.00341. eCollection 
      2020.