PMID- 32657022
OWN - NLM
STAT- MEDLINE
DCOM- 20210624
LR  - 20210624
IS  - 2162-3279 (Electronic)
VI  - 10
IP  - 9
DP  - 2020 Sep
TI  - Intra and inter: Alterations in functional brain resting-state networks after 
      peripheral nerve injury.
PG  - e01747
LID - 10.1002/brb3.1747 [doi]
LID - e01747
AB  - INTRODUCTION: Numerous treatments suggest that brain plasticity changes after 
      peripheral nerve injury (PNI), and most studies examining functional magnetic 
      resonance imaging focused on abnormal changes in specific brain regions. However, 
      it is the large-scale interaction of neuronal networks instead of isolated brain 
      regions contributed to the functional recovery after PNI. In the present study, 
      we examined the intra- and internetworks alterations between the related 
      functional resting-state networks (RSNs) in a sciatic nerve injury rat model. 
      METHODS: Ninety-six female rats were divided into a control and model group. 
      Unilateral sciatic nerve transection and direct anastomosis were performed in the 
      latter group. We used an independent component analysis (ICA) algorithm to 
      observe the changes in RSNs and assessed functional connectivity between 
      different networks using the functional networks connectivity (FNC) toolbox. 
      RESULTS: Six RSNs related to PNI were identified, including the basal ganglia 
      network (BGN), sensorimotor network (SMN), salience network (SN), interoceptive 
      network (IN), cerebellar network (CN), and default mode network (DMN). The model 
      group showed significant changes in whole-brain FC changes within these 
      resting-state networks (RSNs), but four of these RSNs exhibited a conspicuous 
      decrease. The interalterations performed that significantly decreased FNC existed 
      between the BGN and SMN, BGN and IN, and BGN and DMN (p < .05, corrected). A 
      significant increase in FNC existed between DMN and CN and between CN and SN 
      (p < .05, corrected). CONCLUSION: The results showed the large-scale functional 
      reorganization at the network level after PNI. This evidence reveals new 
      implications to the pathophysiological mechanisms in brain plasticity of PNI.
CI  - (c) 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
FAU - Xing, Xiang-Xin
AU  - Xing XX
AD  - School of Rehabilitation Science, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
FAU - Hua, Xu-Yun
AU  - Hua XY
AD  - Department of Traumatology and Orthopedics, Yueyang Hospital, Shanghai University 
      of Traditional Chinese Medicine, Shanghai, China.
AD  - Yangzhi Rehabilitation Hospital, Tongji University, Shanghai, China.
FAU - Zheng, Mou-Xiong
AU  - Zheng MX
AD  - Department of Traumatology and Orthopedics, Yueyang Hospital, Shanghai University 
      of Traditional Chinese Medicine, Shanghai, China.
FAU - Ma, Zhen-Zhen
AU  - Ma ZZ
AD  - School of Rehabilitation Science, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
FAU - Huo, Bei-Bei
AU  - Huo BB
AD  - School of Rehabilitation Science, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
FAU - Wu, Jia-Jia
AU  - Wu JJ
AD  - Center of Rehabilitation Medicine, Yueyang Hospital, Shanghai University of 
      Traditional Chinese Medicine, Shanghai, China.
FAU - Ma, Shu-Jie
AU  - Ma SJ
AD  - School of Rehabilitation Science, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
FAU - Ma, Jie
AU  - Ma J
AD  - School of Rehabilitation Science, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
FAU - Xu, Jian-Guang
AU  - Xu JG
AUID- ORCID: 0000-0003-0601-3403
AD  - School of Rehabilitation Science, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
AD  - Center of Rehabilitation Medicine, Yueyang Hospital, Shanghai University of 
      Traditional Chinese Medicine, Shanghai, China.
LA  - eng
GR  - 2018YFC2001600/National Key R&amp;D Program of China/
GR  - 18511108300/Shanghai Science and Technology Committee/
GR  - 18441903903900/Shanghai Science and Technology Committee/
GR  - 18441903800/Shanghai Science and Technology Committee/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200712
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
SB  - IM
MH  - Animals
MH  - Brain/diagnostic imaging
MH  - *Brain Mapping
MH  - Female
MH  - Magnetic Resonance Imaging
MH  - Nerve Net/diagnostic imaging
MH  - Neuronal Plasticity
MH  - *Peripheral Nerve Injuries/diagnostic imaging
MH  - Rats
PMC - PMC7507705
OTO - NOTNLM
OT  - functional connectivity
OT  - independent component analysis
OT  - peripheral nerve injury
OT  - resting-state network
COIS- The authors declare no conflict of interest. None of the authors have a 
      commercial interest in the material presented in this work.
EDAT- 2020/07/14 06:00
MHDA- 2021/06/25 06:00
PMCR- 2020/07/12
CRDT- 2020/07/14 06:00
PHST- 2020/01/05 00:00 [received]
PHST- 2020/05/18 00:00 [revised]
PHST- 2020/06/04 00:00 [accepted]
PHST- 2020/07/14 06:00 [pubmed]
PHST- 2021/06/25 06:00 [medline]
PHST- 2020/07/14 06:00 [entrez]
PHST- 2020/07/12 00:00 [pmc-release]
AID - BRB31747 [pii]
AID - 10.1002/brb3.1747 [doi]
PST - ppublish
SO  - Brain Behav. 2020 Sep;10(9):e01747. doi: 10.1002/brb3.1747. Epub 2020 Jul 12.