PMID- 32657547
OWN - NLM
STAT- MEDLINE
DCOM- 20210930
LR  - 20210930
IS  - 1097-0339 (Electronic)
IS  - 1097-0339 (Linking)
VI  - 48
IP  - 9
DP  - 2020 Sep
TI  - A comprehensive diagnosis of a desmoplastic small round cell tumor of unusual 
      location based on fine-needle aspiration cytology: Report of a case arising in 
      the parotid gland and review of the literature.
PG  - 827-832
LID - 10.1002/dc.24542 [doi]
AB  - Desmoplastic small round cell tumor (DSRCT) is rare and a highly aggressive 
      neoplasm that typically involves the soft tissues of the abdomen or pelvis in 
      children or young adults, showing a male predilection. Although it can occurs 
      over a wide age range, the peak incidence is in the third decade of life. DSRCT 
      usually shows widespread abdominal serosal involvement, and overall patient 
      survival is poor. On the other hand, extra-abdominal DSRCT is very rare. DSRCT in 
      major salivary glands has been reported, but it is extremely rare. In the 
      majority of reported series diagnosis is made by the histological analysis of 
      FFPE tissues together with immunohistochemistry (IHC) and molecular analysis, 
      particularly the demonstration of chromosomal translocation involving EWSR1. Very 
      few cases have been diagnosed so far by Fine Needle Aspiration (FNA) cytology. 
      Moreover ancillary studies have been performed in all reported cases in FFPE 
      samples. There is still controversy and lack of consensus regarding the 
      suitability of cytological samples especially smears for immunocytochemical (ICC) 
      and fluorescence in situ hybridization (FISH), what makes its standardization 
      difficult. We report a case of a primary DSRCT of parotid gland in a 17-year-old 
      male diagnosed by FNA cytology. The cytomorphological diagnosis was coupled with 
      ICC and FISH analysis performed on stained smears. We emphasize the feasibility 
      and reliability of cytological smears for the application of immunocytochemical 
      and molecular techniques.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Lozano, Maria D
AU  - Lozano MD
AUID- ORCID: 0000-0002-6796-9380
AD  - Department of Pathology, Clinica University of Navarra, Pamplona, Spain.
FAU - Landa, Ana
AU  - Landa A
AD  - Medical Oncology, University Hospital of San Sebastian, San Sebastian, Spain.
FAU - Tobar, Laura G
AU  - Tobar LG
AD  - Department of Pathology, Clinica University of Navarra, Pamplona, Spain.
FAU - De Andrea, Carlos
AU  - De Andrea C
AD  - Department of Pathology, Clinica University of Navarra, Pamplona, Spain.
FAU - Larrache, Javier
AU  - Larrache J
AD  - Department of Radiology, Clinica University of Navarra, Pamplona, Spain.
FAU - Echeveste, Jose I
AU  - Echeveste JI
AD  - Department of Pathology, Clinica University of Navarra, Pamplona, Spain.
FAU - Paricio, Jose J
AU  - Paricio JJ
AD  - Department of Pathology, Clinica University of Navarra, Pamplona, Spain.
FAU - Sanchez, Beatriz
AU  - Sanchez B
AD  - Medical Oncology, University Hospital of San Sebastian, San Sebastian, Spain.
FAU - Medina, Andrea
AU  - Medina A
AD  - Medical Oncology, University Hospital of San Sebastian, San Sebastian, Spain.
FAU - Paisan, Ana
AU  - Paisan A
AD  - Medical Oncology, University Hospital of San Sebastian, San Sebastian, Spain.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20200713
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
SB  - IM
MH  - Adolescent
MH  - Biopsy, Fine-Needle/methods
MH  - Cytodiagnosis/methods
MH  - Desmoplastic Small Round Cell Tumor/*diagnosis/*pathology
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - Male
MH  - Parotid Gland/*pathology
OTO - NOTNLM
OT  - DSRCT parotid
OT  - FISH
OT  - FNA cytology
OT  - ICC
OT  - stained smears
EDAT- 2020/07/14 06:00
MHDA- 2021/10/01 06:00
CRDT- 2020/07/14 06:00
PHST- 2020/04/21 00:00 [received]
PHST- 2020/06/04 00:00 [revised]
PHST- 2020/06/18 00:00 [accepted]
PHST- 2020/07/14 06:00 [pubmed]
PHST- 2021/10/01 06:00 [medline]
PHST- 2020/07/14 06:00 [entrez]
AID - 10.1002/dc.24542 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 2020 Sep;48(9):827-832. doi: 10.1002/dc.24542. Epub 2020 Jul 
      13.