PMID- 32659700
OWN - NLM
STAT- MEDLINE
DCOM- 20210527
LR  - 20221207
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 86
DP  - 2020 Sep
TI  - IL-7R gene variants are associated with breast cancer susceptibility in Chinese 
      Han women.
PG  - 106756
LID - S1567-5769(20)31517-4 [pii]
LID - 10.1016/j.intimp.2020.106756 [doi]
AB  - BACKGROUND: Interleukin 7 receptor (IL-7R) is a member of the type I cytokine 
      receptor family, which affects the occurrence of various tumors by forming a 
      signaling complex with its ligand Interleukin 7 (IL-7). This study aimed to 
      explore the potential relationships of IL-7R polymorphisms with breast cancer 
      susceptibility in the Chinese Han women. METHODS: Five polymorphisms of IL-7R 
      gene (rs969129, rs10213865, rs10053847, rs118137916, and rs6451231) form 553 
      patients and 550 healthy individuals among the Chinese Han women were genotyped 
      using Agena MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals 
      (95% CIs) were calculated to evaluate the relationship. RESULTS: The resulted of 
      this study showed that rs10213865 was related to an increased breast cancer risk 
      in allele (P = 0.045), dominant (P = 0.040), and log-additive (P = 0.029) models. 
      As for rs969129, an increased risk of breast cancer was found in the allele 
      (P = 0.018), co-dominant (P = 0.017), recessive (P = 0.034), and additive 
      (P = 0.019) models. Rs6451231 was related to an increased risk of breast cancer 
      under allele (P = 0.018), co-dominant (P = 0.021), and log-additive (P = 0.019) 
      models. Age stratified analysis revealed that rs6451231 could enhance risk of 
      breast cancer among the individuals older than 52 years. Furthermore, there was a 
      significant correlation between haplotype 
      C(rs969129)G(rs10213865)A(rs10053847)G(rs118137916) and the decreased risk of 
      breast cancer (P = 0.010). CONCLUSIONS: This study firstly proved that IL-7R 
      polymorphisms were significantly correlated with an increased susceptibility of 
      breast cancer in the Chinese Han women.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Wang, Zhenghua
AU  - Wang Z
AD  - Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi 710061, China; Department of Medical Oncology, The 
      First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 
      121004, China.
FAU - Wang, Xiaoyu
AU  - Wang X
AD  - Department of Medical Oncology, The First Affiliated Hospital of Jinzhou Medical 
      University, Jinzhou, Liaoning 121004, China.
FAU - Gao, Yu
AU  - Gao Y
AD  - Department of Medical Oncology, The First Affiliated Hospital of Jinzhou Medical 
      University, Jinzhou, Liaoning 121004, China.
FAU - Wang, Yuanyuan
AU  - Wang Y
AD  - Department of Medical Oncology, The First Affiliated Hospital of Jinzhou Medical 
      University, Jinzhou, Liaoning 121004, China.
FAU - Xu, Minghao
AU  - Xu M
AD  - Department of Medical Oncology, The First Affiliated Hospital of Jinzhou Medical 
      University, Jinzhou, Liaoning 121004, China.
FAU - Han, Qiuyue
AU  - Han Q
AD  - Department of Medical Oncology, The First Affiliated Hospital of Jinzhou Medical 
      University, Jinzhou, Liaoning 121004, China.
FAU - Zhao, Xinhan
AU  - Zhao X
AD  - Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi 710061, China. Electronic address: 
      zhaoxinhan@mail.xjtu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200710
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Receptors, Interleukin-7)
SB  - IM
MH  - Adult
MH  - *Asian People
MH  - Breast Neoplasms/epidemiology/*genetics
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - *Genotype
MH  - Humans
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, Interleukin-7/*genetics
MH  - Risk
OTO - NOTNLM
OT  - Breast cancer
OT  - Cancer susceptibility
OT  - IL-7R
OT  - Polymorphisms
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/07/14 06:00
MHDA- 2021/05/28 06:00
CRDT- 2020/07/14 06:00
PHST- 2020/05/11 00:00 [received]
PHST- 2020/06/11 00:00 [revised]
PHST- 2020/06/26 00:00 [accepted]
PHST- 2020/07/14 06:00 [pubmed]
PHST- 2021/05/28 06:00 [medline]
PHST- 2020/07/14 06:00 [entrez]
AID - S1567-5769(20)31517-4 [pii]
AID - 10.1016/j.intimp.2020.106756 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2020 Sep;86:106756. doi: 10.1016/j.intimp.2020.106756. Epub 
      2020 Jul 10.