PMID- 32660239
OWN - NLM
STAT- MEDLINE
DCOM- 20201127
LR  - 20201127
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 54
IP  - 16
DP  - 2020 Aug 18
TI  - Ambient PM Toxicity Is Correlated with Expression Levels of Specific MicroRNAs.
PG  - 10227-10236
LID - 10.1021/acs.est.0c03876 [doi]
AB  - Uncertainties regarding optimized air pollution control remain as the underlying 
      mechanisms of city-specific ambient particulate matter (PM)-induced health 
      effects are unknown. Here, water-soluble extracts of PMs collected from four 
      global cities via automobile air-conditioning filters were consecutively injected 
      three times by an amount of 1, 2, and 2 mg into the blood circulation of Wistar 
      rats after filtration by a 0.45 mum pore size membrane. Acute health effects, such 
      as immune and inflammatory responses and hemorrhage in alveoli, were observed 
      right after the PM extraction injection. Significant differences between cities 
      in biomarker tumor necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant 
      protein-1 (MCP-1) levels were detected following the second and third PM 
      injections. Rats' inflammatory responses varied substantially with the injections 
      of city-specific PMs. Repeated PM extract exposure rendered the rats more 
      vulnerable to subsequent challenges, and downregulation of certain microRNAs was 
      observed in rats. Among the studied miRNAs, miR-125b, and miR-21 were most 
      sensitive to the PM exposure, exhibiting a negative dose-response-type 
      relationship with a source-specific PM (oxidative potential) toxicity (r(2) = 
      0.63 and 0.57; p-values < 0.05). The results indicated that city-specific PMs 
      could induce different health effects by selectively regulating different miRNAs, 
      and that certain microRNAs, e.g., miR-125b and miR-21, may be externally mediated 
      to neutralize PM-related health damages.
FAU - Chen, Haoxuan
AU  - Chen H
AUID- ORCID: 0000-0001-8398-9093
AD  - State Key Joint Laboratory of Environmental Simulation and Pollution Control, 
      College of Environmental Sciences and Engineering, Peking University, Beijing 
      100871, China.
FAU - Zhang, Xiangyu
AU  - Zhang X
AD  - State Key Joint Laboratory of Environmental Simulation and Pollution Control, 
      College of Environmental Sciences and Engineering, Peking University, Beijing 
      100871, China.
FAU - Zhang, Ting
AU  - Zhang T
AD  - State Key Joint Laboratory of Environmental Simulation and Pollution Control, 
      College of Environmental Sciences and Engineering, Peking University, Beijing 
      100871, China.
FAU - Li, Xinyue
AU  - Li X
AD  - State Key Joint Laboratory of Environmental Simulation and Pollution Control, 
      College of Environmental Sciences and Engineering, Peking University, Beijing 
      100871, China.
FAU - Li, Jing
AU  - Li J
AD  - Linde + Robinson Laboratories, California Institute of Technology, Pasadena, 
      California 91125, United States.
FAU - Yue, Yang
AU  - Yue Y
AD  - Institute of Environmental Engineering, ETH Zurich, Zurich 8093, Switzerland.
AD  - Laboratory for Advanced Analytical Technologies, Empa, Swiss Federal Laboratories 
      for Materials Science and Technology, Dubendorf 8600, Switzerland.
FAU - Wang, Minfei
AU  - Wang M
AD  - State Key Joint Laboratory of Environmental Simulation and Pollution Control, 
      College of Environmental Sciences and Engineering, Peking University, Beijing 
      100871, China.
FAU - Zheng, Yunhao
AU  - Zheng Y
AUID- ORCID: 0000-0002-5788-886X
AD  - Institute of Environment and Sustainable Development in Agriculture, Chinese 
      Academy of Agricultural Sciences, Beijing 100081, China.
FAU - Fan, Hanqing
AU  - Fan H
AD  - Department of Earth and Environmental Engineering, Columbia University, New York, 
      New York 10027, United States.
FAU - Wang, Jing
AU  - Wang J
AUID- ORCID: 0000-0003-2078-137X
AD  - Institute of Environmental Engineering, ETH Zurich, Zurich 8093, Switzerland.
AD  - Laboratory for Advanced Analytical Technologies, Empa, Swiss Federal Laboratories 
      for Materials Science and Technology, Dubendorf 8600, Switzerland.
FAU - Yao, Maosheng
AU  - Yao M
AUID- ORCID: 0000-0002-1442-8054
AD  - State Key Joint Laboratory of Environmental Simulation and Pollution Control, 
      College of Environmental Sciences and Engineering, Peking University, Beijing 
      100871, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200727
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Air Pollutants)
RN  - 0 (MicroRNAs)
RN  - 0 (Particulate Matter)
SB  - IM
MH  - *Air Pollutants/analysis/toxicity
MH  - Animals
MH  - Cities
MH  - *MicroRNAs/genetics
MH  - Particle Size
MH  - Particulate Matter/analysis/toxicity
MH  - Rats
MH  - Rats, Wistar
EDAT- 2020/07/15 06:00
MHDA- 2020/11/28 06:00
CRDT- 2020/07/15 06:00
PHST- 2020/07/15 06:00 [pubmed]
PHST- 2020/11/28 06:00 [medline]
PHST- 2020/07/15 06:00 [entrez]
AID - 10.1021/acs.est.0c03876 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2020 Aug 18;54(16):10227-10236. doi: 
      10.1021/acs.est.0c03876. Epub 2020 Jul 27.