PMID- 32660584 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200928 IS - 2234-0726 (Print) IS - 2234-2451 (Electronic) IS - 2234-0726 (Linking) VI - 32 IP - 1 DP - 2020 Apr 9 TI - Minimal clinically important difference of commonly used patient-reported outcome measures in total knee arthroplasty: review of terminologies, methods and proposed values. PG - 19 LID - 10.1186/s43019-020-00038-3 [doi] LID - 19 AB - PURPOSE: The aim of this article was to highlight various terminologies and methods of calculation of minimal clinically important difference (MCID) and summarize MCID values of frequently used patient-reported outcome measures (PROMs) evaluating total knee arthroplasty (TKA). MATERIALS AND METHODS: PubMed and EMBASE databases were searched through May 2019. Of 71 articles identified, 18 articles matched and underwent a comprehensive analysis for terminologies used to indicate clinical significance, method of calculation, and reported MCID values. RESULTS: MCID was the most common terminology (67% studies) and anchor-based methods were most commonly employed (67% studies) to calculate it. The analytical methods used to calculate and the estimated values of MCID for clinical use are highly variable. MCID values reported for WOMAC scores are 20.5 to 36.0, 17.6 to 33.0 and 12.9 to 25.0 for pain, function and stiffness sub-scales, respectively, and 4.7 to 10.0 for OKS. CONCLUSION: There was lack of standardization in the methodology employed to calculate MCID in the available studies. MCID values reported in this review could be used for patients undergoing TKA, although caution is advised in their interpretation and application. FAU - Maredupaka, Siddhartha AU - Maredupaka S AD - TK Orthopedic Surgery, 55 Dongpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13535, Republic of Korea. FAU - Meshram, Prashant AU - Meshram P AD - TK Orthopedic Surgery, 55 Dongpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13535, Republic of Korea. FAU - Chatte, Manish AU - Chatte M AD - TK Orthopedic Surgery, 55 Dongpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13535, Republic of Korea. FAU - Kim, Woo Hyun AU - Kim WH AD - TK Orthopedic Surgery, 55 Dongpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13535, Republic of Korea. FAU - Kim, Tae Kyun AU - Kim TK AD - TK Orthopedic Surgery, 55 Dongpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13535, Republic of Korea. osktk2000@yahoo.com. LA - eng PT - Journal Article PT - Review DEP - 20200409 PL - England TA - Knee Surg Relat Res JT - Knee surgery & related research JID - 101575761 PMC - PMC7219224 OTO - NOTNLM OT - Knee osteoarthritis OT - MCID OT - Minimal clinical difference OT - Minimal clinically important difference OT - Total knee arthroplasty COIS- One of the authors certifies that he (TKK) has received during study period, an amount of less than USD 10,000 from Smith and Nephew (Memphis, TN, USA), has received during the study period, an amount of less than USD 10,000 from B. Braun (Tuttlingen, Baden Wurttemberg, Germany), outside the submitted work. The author certifies that neither (s)he, nor any members of their family, have any commercial association (such as consultancies, stock ownership, equity interest, patent/licensing arrangements etc.) that might pose a conflict of interest in connection with the submitted article. EDAT- 2020/07/15 06:00 MHDA- 2020/07/15 06:01 PMCR- 2020/04/09 CRDT- 2020/07/15 06:00 PHST- 2019/12/05 00:00 [received] PHST- 2020/03/13 00:00 [accepted] PHST- 2020/07/15 06:00 [entrez] PHST- 2020/07/15 06:00 [pubmed] PHST- 2020/07/15 06:01 [medline] PHST- 2020/04/09 00:00 [pmc-release] AID - 10.1186/s43019-020-00038-3 [pii] AID - 38 [pii] AID - 10.1186/s43019-020-00038-3 [doi] PST - epublish SO - Knee Surg Relat Res. 2020 Apr 9;32(1):19. doi: 10.1186/s43019-020-00038-3.