PMID- 32660629
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220415
IS  - 2234-0726 (Print)
IS  - 2234-2451 (Electronic)
IS  - 2234-0726 (Linking)
VI  - 32
IP  - 1
DP  - 2020 Jun 17
TI  - Sex does not clinically influence the functional outcome of total knee 
      arthroplasty but females have a lower rate of satisfaction with pain relief.
PG  - 32
LID - 10.1186/s43019-020-00048-1 [doi]
LID - 32
AB  - BACKGROUND: The aims were to assess whether sex had a clinically significant 
      independent influence on the outcome of total knee arthroplasty (TKA) according 
      to the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) 
      score, Short Form (SF-) 12 scores and patient satisfaction at 1 year. METHODS: A 
      retrospective cohort of 3510 primary TKA were identified. Patient demographics, 
      comorbidities, WOMAC and SF-12 scores were collected preoperatively and 1 year 
      postoperatively. Patient satisfaction were assessed at 1 year. RESULTS: There 
      were 1584 males and 1926 females. The preoperative WOMAC and SF-12 scores were 
      significantly (p < 0.001) worse in females but were not greater than the minimal 
      clinically important difference (MCID). When adjustments had been made for 
      confounding differences, females showed a significantly greater improvement in 
      their function (1.5 points, p = 0.03) and total (1.5 points, p = 0.03) WOMAC 
      scores compared to males, but these were not greater than the MCID. When 
      adjustments had been made for confounding differences, females were less likely 
      to be satisfied with their pain relief (p = 0.03) relative to males. CONCLUSION: 
      Sex does not clinically influence the knee specific outcome (WOMAC) or overall 
      generic (SF-12) health 1 year after TKA. However, satisfaction with pain relief 
      after TKA was significantly less likely in female patients. LEVEL OF EVIDENCE II: 
      Prognostic retrospective cohort study.
FAU - Clement, N D
AU  - Clement ND
AUID- ORCID: 0000-0001-8792-0659
AD  - Department of Orthopaedics, Freeman Hospital, Newcastle upon Tyne Hospitals NHS 
      Foundation Trust, Freeman Road, High Heaton, Newcastle upon Tyne, NE7 7DN, UK. 
      nickclement@doctors.org.uk.
FAU - Weir, D
AU  - Weir D
AD  - Department of Orthopaedics, Freeman Hospital, Newcastle upon Tyne Hospitals NHS 
      Foundation Trust, Freeman Road, High Heaton, Newcastle upon Tyne, NE7 7DN, UK.
FAU - Holland, J
AU  - Holland J
AD  - Department of Orthopaedics, Freeman Hospital, Newcastle upon Tyne Hospitals NHS 
      Foundation Trust, Freeman Road, High Heaton, Newcastle upon Tyne, NE7 7DN, UK.
FAU - Deehan, D J
AU  - Deehan DJ
AD  - Department of Orthopaedics, Freeman Hospital, Newcastle upon Tyne Hospitals NHS 
      Foundation Trust, Freeman Road, High Heaton, Newcastle upon Tyne, NE7 7DN, UK.
LA  - eng
PT  - Journal Article
DEP - 20200617
PL  - England
TA  - Knee Surg Relat Res
JT  - Knee surgery & related research
JID - 101575761
PMC - PMC7301486
OTO - NOTNLM
OT  - Outcome
OT  - Satisfaction
OT  - Sex
OT  - Total knee arthroplasty
OT  - WOMAC
COIS- David Weir is an educational lecturer for Stryker. Jim Holland is an educational 
      lecturer for Zimmer. The other authors declare that they have no competing 
      interests.
EDAT- 2020/07/15 06:00
MHDA- 2020/07/15 06:01
PMCR- 2020/06/17
CRDT- 2020/07/15 06:00
PHST- 2020/02/12 00:00 [received]
PHST- 2020/05/21 00:00 [accepted]
PHST- 2020/07/15 06:00 [entrez]
PHST- 2020/07/15 06:00 [pubmed]
PHST- 2020/07/15 06:01 [medline]
PHST- 2020/06/17 00:00 [pmc-release]
AID - 10.1186/s43019-020-00048-1 [pii]
AID - 48 [pii]
AID - 10.1186/s43019-020-00048-1 [doi]
PST - epublish
SO  - Knee Surg Relat Res. 2020 Jun 17;32(1):32. doi: 10.1186/s43019-020-00048-1.