PMID- 32661611
OWN - NLM
STAT- MEDLINE
DCOM- 20201201
LR  - 20201201
IS  - 1534-3111 (Electronic)
IS  - 1522-6417 (Print)
IS  - 1522-6417 (Linking)
VI  - 22
IP  - 7
DP  - 2020 Jul 13
TI  - Molecular Mechanisms Underlying the Circadian Rhythm of Blood Pressure in 
      Normotensive Subjects.
PG  - 50
LID - 10.1007/s11906-020-01063-z [doi]
LID - 50
AB  - PURPOSE OF REVIEW: Blood pressure (BP) follows a circadian rhythm (CR) in 
      normotensive subjects. BP increases in the morning and decreases at night. This 
      review aims at providing an up-to-date overview regarding the molecular 
      mechanisms underlying the circadian regulation of BP. RECENT FINDINGS: The 
      suprachiasmatic nucleus (SCN) is the regulatory center for CRs. In SCN 
      astrocytes, the phosphorylated glycogen synthase kinase-3beta (pGSK-3beta) also follows 
      a CR and its expression reaches a maximum in the morning and decreases at night. 
      pGSK-3beta induces the beta-catenin migration to the nucleus. During the daytime, the 
      nuclear beta-catenin increases the expression of the glutamate excitatory amino acid 
      transporter 2 (EAAT2) and glutamine synthetase (GS). In SCN, EAAT2 removes 
      glutamate from the synaptic cleft of glutamatergic neurons and transfers it to 
      the astrocyte cytoplasm where GS converts glutamate into glutamine. Thus, 
      glutamate decreases in the synaptic cleft. This decreases the stimulation of the 
      glutamate receptors AMPA-R and NMDA-R located on glutamatergic post-synaptic 
      neurons. Consequently, activation of NTS is decreased and BP increases. The 
      opposite occurs at night. Despite several studies resulting from animal studies, 
      the circadian regulation of BP appears largely controlled in normotensive 
      subjects by the canonical WNT/beta-catenin pathway involving the SCN, astrocytes, 
      and glutamatergic neurons.
FAU - Lecarpentier, Yves
AU  - Lecarpentier Y
AD  - Centre de Recherche Clinique, Grand Hopital de l'Est Francilien, 77104, Meaux, 
      France. yves.c.lecarpentier@gmail.com.
FAU - Schussler, Olivier
AU  - Schussler O
AD  - Department of Thoracic surgery, Nouvel Hopital Civil, Hopitaux Universitaires de 
      Strasbourg, Strasbourg, France.
AD  - Department of Cardiovascular Surgery, Research Laboratory, Geneva University 
      Hospital, Geneva, Switzerland.
FAU - Hebert, Jean-Louis
AU  - Hebert JL
AD  - Cardiology Institute, Pitie-Salpetriere Hospital, AP-HP, Paris, France.
FAU - Vallee, Alexandre
AU  - Vallee A
AD  - Diagnosis and Therapeutic Center, Hypertension and Cardiovascular Prevention 
      Unit, Paris-Descartes University, Hotel-Dieu Hospital, AP-HP, Paris, France.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200713
PL  - United States
TA  - Curr Hypertens Rep
JT  - Current hypertension reports
JID - 100888982
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Animals
MH  - Blood Pressure
MH  - *Circadian Rhythm
MH  - Glutamic Acid
MH  - Humans
MH  - *Hypertension
MH  - Suprachiasmatic Nucleus
PMC - PMC7359176
OTO - NOTNLM
OT  - Arterial blood pressure
OT  - Astrocyte
OT  - Canonical WNT/beta-catenin pathway
OT  - Circadian rhythm
OT  - Glutamine synthetase, nucleus tractus solitarius
OT  - Glycogen synthase kinase
OT  - Suprachiasmatic nucleus
COIS- The authors declare no conflicts of interest relevant to this manuscript.
EDAT- 2020/07/15 06:00
MHDA- 2020/12/02 06:00
PMCR- 2020/07/13
CRDT- 2020/07/15 06:00
PHST- 2020/07/15 06:00 [entrez]
PHST- 2020/07/15 06:00 [pubmed]
PHST- 2020/12/02 06:00 [medline]
PHST- 2020/07/13 00:00 [pmc-release]
AID - 10.1007/s11906-020-01063-z [pii]
AID - 1063 [pii]
AID - 10.1007/s11906-020-01063-z [doi]
PST - epublish
SO  - Curr Hypertens Rep. 2020 Jul 13;22(7):50. doi: 10.1007/s11906-020-01063-z.