PMID- 32661700 OWN - NLM STAT- MEDLINE DCOM- 20210818 LR - 20210818 IS - 1435-702X (Electronic) IS - 0721-832X (Linking) VI - 258 IP - 12 DP - 2020 Dec TI - Paracentral acute middle maculopathy-review of the literature. PG - 2583-2596 LID - 10.1007/s00417-020-04826-1 [doi] AB - Paracentral acute middle maculopathy (PAMM) is a recently identified spectral-domain optical coherence tomography (SD-OCT) finding characterized by a hyper-reflective band spanning the inner nuclear layer (INL), which typically evolves to INL atrophy in later stages. Typical clinical features include the sudden onset of one or multiple paracentral scotomas, normal or mild reduction in visual acuity, and a normal fundus appearance or a fundus with a deep grayish lesion. Although its pathophysiology is not yet fully understood, ischemia at the level of the intermediate and deep capillary plexa has been demonstrated to play a major role. Since its first description, an increasing number of publications on PAMM have been published in ophthalmology scientific journals. The purpose of this study is to provide a review of the current literature on PAMM. FAU - Moura-Coelho, Nuno AU - Moura-Coelho N AUID- ORCID: 0000-0002-5176-1411 AD - Ophthalmology, Centro Hospitalar Universitario Lisboa Central (CHULC), Centro Hospitalar Universitario Lisboa Central, Rua Jose Antonio Serrano, 1150-199, Lisbon, Portugal. nunomouracoelho.oft@gmail.com. AD - NOVA Medical School, Faculdade de Ciencias Medicas - Universidade Nova de Lisboa (NMS|FCM-UNL), Centro Hospitalar Universitario Lisboa Central, Rua Jose Antonio Serrano, 1150-199, Lisbon, Portugal. nunomouracoelho.oft@gmail.com. AD - Ophthalmology, Instituto Portugues de Retina (IPR), Lisbon, Portugal. nunomouracoelho.oft@gmail.com. FAU - Gaspar, Teresa AU - Gaspar T AD - NOVA Medical School, Faculdade de Ciencias Medicas - Universidade Nova de Lisboa (NMS|FCM-UNL), Centro Hospitalar Universitario Lisboa Central, Rua Jose Antonio Serrano, 1150-199, Lisbon, Portugal. tcatarinarg@gmail.com. AD - Internal Medicine, Centro Hospitalar Barreiro-Montijo (CHBM), Centro Hospitalar Barreiro-Montijo, Avenida Movimento das Forcas Armadas, 2834-003, Barreiro, Portugal. tcatarinarg@gmail.com. FAU - Ferreira, Joana Tavares AU - Ferreira JT AD - Ophthalmology Department, Hospital CUF Cascais, Cascais, Portugal. AD - Ophthalmology Department, Hospital CUF Descobertas, Lisbon, Portugal. AD - Ophthalmology, Escola Superior de Tecnologia da Saude de Lisboa do Instituto Politecnico de Lisboa, Lisbon, Portugal. AD - Centro de Estudos das Ciencias da Visao, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal. FAU - Dutra-Medeiros, Marco AU - Dutra-Medeiros M AD - Ophthalmology, Centro Hospitalar Universitario Lisboa Central (CHULC), Centro Hospitalar Universitario Lisboa Central, Rua Jose Antonio Serrano, 1150-199, Lisbon, Portugal. AD - NOVA Medical School, Faculdade de Ciencias Medicas - Universidade Nova de Lisboa (NMS|FCM-UNL), Centro Hospitalar Universitario Lisboa Central, Rua Jose Antonio Serrano, 1150-199, Lisbon, Portugal. AD - Ophthalmology, Instituto Portugues de Retina (IPR), Lisbon, Portugal. AD - Ophthalmology, Associacao Protectora dos Diabeticos de Portugal (APDP), Lisbon, Portugal. FAU - Cunha, Joao Paulo AU - Cunha JP AD - Ophthalmology Department, Hospital CUF Cascais, Cascais, Portugal. AD - Ophthalmology, Escola Superior de Tecnologia da Saude de Lisboa do Instituto Politecnico de Lisboa, Lisbon, Portugal. LA - eng PT - Journal Article PT - Review DEP - 20200713 PL - Germany TA - Graefes Arch Clin Exp Ophthalmol JT - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JID - 8205248 SB - IM MH - Fluorescein Angiography MH - Humans MH - *Macular Degeneration MH - *Retinal Diseases/diagnosis MH - Retinal Vessels MH - Tomography, Optical Coherence OTO - NOTNLM OT - Deep capillary ischemia OT - Paracentral acute middle maculopathy OT - Retinal imaging OT - Spectral-domain optical coherence tomography, optical coherence tomography angiography EDAT- 2020/07/15 06:00 MHDA- 2021/08/19 06:00 CRDT- 2020/07/15 06:00 PHST- 2019/11/26 00:00 [received] PHST- 2020/07/03 00:00 [accepted] PHST- 2020/06/29 00:00 [revised] PHST- 2020/07/15 06:00 [pubmed] PHST- 2021/08/19 06:00 [medline] PHST- 2020/07/15 06:00 [entrez] AID - 10.1007/s00417-020-04826-1 [pii] AID - 10.1007/s00417-020-04826-1 [doi] PST - ppublish SO - Graefes Arch Clin Exp Ophthalmol. 2020 Dec;258(12):2583-2596. doi: 10.1007/s00417-020-04826-1. Epub 2020 Jul 13.