PMID- 32662507
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 46
IP  - 6
DP  - 2020 Dec 1
TI  - Longitudinal Assessment and Functional Neuroimaging of Movement Variability 
      Reveal Novel Insights Into Motor Dysfunction in Clinical High Risk for Psychosis.
PG  - 1567-1576
LID - 10.1093/schbul/sbaa072 [doi]
AB  - Motor dysfunction in youth at clinical high risk (CHR) for psychosis is thought 
      to reflect abnormal neurodevelopment within cortical-subcortical motor circuits 
      and may be important for understanding clinical trajectories of CHR individuals. 
      However, to date, our perspective of brain-behavior relationships has been 
      informed solely by cross-sectional correlational studies linking behavior in the 
      lab to brain structure or respective resting-state network connectivity. Here, we 
      assess movement dysfunction from 2 perspectives: study 1 investigates the 
      longitudinal progression of handwriting variability and positive symptoms in a 
      sample of 91 CHR and healthy controls during a 12-month follow-up and study 2 
      involves a multiband functional magnetic resonance imaging task exploring the 
      relationship between power grip force stability and motor network brain 
      activation in a subset of participants. In study 1, we found that greater 
      handwriting variability was a stable feature of CHR participants who experienced 
      worse symptom progression. Study 2 results showed that CHR individuals had 
      greater variability in their grip force and greater variability was related to 
      decreased activation in the associative cortico-striatal network compared to 
      controls. Motor variability may be a stable marker of vulnerability for psychosis 
      risk and possible indicator of a vulnerable cortico-striatal brain network 
      functioning in CHR participants, although the effects of antipsychotic medication 
      should be considered.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of the 
      Maryland Psychiatric Research Center.All rights reserved. For permissions, please 
      email: journals.permissions@oup.com.
FAU - Dean, Derek J
AU  - Dean DJ
AD  - Department of Psychology, Vanderbilt University, Nashville, TN.
FAU - Bernard, Jessica A
AU  - Bernard JA
AD  - Department of Psychological and Brain Sciences, Texas A&M University, College 
      Station, TX.
AD  - Institute for Neuroscience, Texas A&M University, College Station, TX.
FAU - Damme, Katherine S F
AU  - Damme KSF
AD  - Department of Psychology, Northwestern University, Evanston, IL.
FAU - O'Reilly, Randall
AU  - O'Reilly R
AD  - Departments of Psychology, Computer Science, and Center for Neuroscience, 
      University of California Davis, Davis, CA.
FAU - Orr, Joseph M
AU  - Orr JM
AD  - Department of Psychological and Brain Sciences, Texas A&M University, College 
      Station, TX.
AD  - Institute for Neuroscience, Texas A&M University, College Station, TX.
FAU - Mittal, Vijay A
AU  - Mittal VA
AD  - Department of Psychology, Northwestern University, Evanston, IL.
AD  - Department of Psychiatry, Northwestern University, Chicago IL.
AD  - Institute for Policy Research, Northwestern University, Evanston, IL.
AD  - Department of Medical Social Sciences, Northwestern University, Chicago, IL.
AD  - Institute for Innovations in Developmental Sciences, Northwestern University, 
      Evanston/Chicago, IL.
LA  - eng
GR  - R21 MH103231/MH/NIMH NIH HHS/United States
GR  - R21 MH110374/MH/NIMH NIH HHS/United States
GR  - R33 MH103231/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cerebral Cortex/diagnostic imaging/*physiopathology
MH  - Child
MH  - Corpus Striatum/diagnostic imaging/*physiopathology
MH  - *Disease Progression
MH  - Disease Susceptibility
MH  - Female
MH  - Functional Neuroimaging
MH  - Hand Strength/*physiology
MH  - *Handwriting
MH  - Humans
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Motor Activity/*physiology
MH  - Motor Skills/*physiology
MH  - Nerve Net/diagnostic imaging/*physiopathology
MH  - Psychotic Disorders/diagnostic imaging/*physiopathology
MH  - Risk
MH  - Young Adult
PMC - PMC7707079
OTO - NOTNLM
OT  - clinical high risk
OT  - functional magnetic resonance imaging
OT  - handwriting
OT  - longitudinal
OT  - motor control
OT  - power grip
OT  - variability
EDAT- 2020/07/15 06:00
MHDA- 2021/10/26 06:00
PMCR- 2021/07/14
CRDT- 2020/07/15 06:00
PHST- 2020/07/15 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2020/07/15 06:00 [entrez]
PHST- 2021/07/14 00:00 [pmc-release]
AID - 5871221 [pii]
AID - sbaa072 [pii]
AID - 10.1093/schbul/sbaa072 [doi]
PST - ppublish
SO  - Schizophr Bull. 2020 Dec 1;46(6):1567-1576. doi: 10.1093/schbul/sbaa072.