PMID- 32662625
OWN - NLM
STAT- MEDLINE
DCOM- 20210216
LR  - 20210216
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 12
IP  - 31
DP  - 2020 Aug 5
TI  - Hollow Mesoporous Silica Nanoparticles with Extra-Large Mesopores for Enhanced 
      Cancer Vaccine.
PG  - 34658-34666
LID - 10.1021/acsami.0c09484 [doi]
AB  - Owing to the limitations of conventional cancer therapies, cancer immunotherapy 
      has emerged for the prevention of cancer recurrence. To provoke adaptive immune 
      responses that are antigen-specific, it is important to develop an efficient 
      antigen delivery system that can enhance the activation and maturation of the 
      dendritic cells (DCs) in the human body. In this study, we synthesize hollow 
      mesoporous silica nanoparticles with extra-large mesopores (H-XL-MSNs) based on a 
      single-step synthesis from core-shell mesoporous silica nanoparticles with a core 
      composed of an assembly of iron oxide nanoparticles. The hollow void inside the 
      mesoporous silica nanoparticles with large mesopores allows a high loading 
      efficiency of various model proteins of different sizes. The H-XL-MSNs are coated 
      with a poly(ethyleneimine) (PEI) solution to provide an immune adjuvant and 
      change the surface charge of the particles for loading and slow release of a 
      model antigen. An in vitro study using a cancer vaccine based on the PEI-coated 
      H-XL-MSNs with the loading of the model antigen showed an enhanced activation of 
      the DCs. An in vivo study demonstrated that the resulting cancer vaccine 
      increased the antigen-specific cytotoxic T cells, enhanced the suppression of 
      tumor growth, and improved the survival rate after challenging cancer to mice. 
      These findings suggest that these hollow MSNs with extra-large pores can be used 
      as excellent antigen carriers for immunotherapy.
FAU - Lee, Jun Yup
AU  - Lee JY
AD  - School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, 
      Republic of Korea.
FAU - Kim, Min Kyung
AU  - Kim MK
AD  - Department of Health Sciences and Technology, Samsung Advanced Institute for 
      Health Sciences & Technology (SAIHST), Sungkyunkwan University (SKKU), Suwon 
      16419, Republic of Korea.
FAU - Nguyen, Thanh Loc
AU  - Nguyen TL
AD  - School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, 
      Republic of Korea.
FAU - Kim, Jaeyun
AU  - Kim J
AUID- ORCID: 0000-0002-4687-6732
AD  - School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, 
      Republic of Korea.
AD  - Department of Health Sciences and Technology, Samsung Advanced Institute for 
      Health Sciences & Technology (SAIHST), Sungkyunkwan University (SKKU), Suwon 
      16419, Republic of Korea.
AD  - Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University 
      (SKKU), Suwon 16419, Republic of Korea.
AD  - Institute of Quantum Biophysics (IQB), Sungkyunkwan University (SKKU), Suwon 
      16419, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20200728
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Cancer Vaccines)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Adjuvants, Immunologic
MH  - Animals
MH  - Cancer Vaccines/chemistry/*immunology
MH  - Dendritic Cells/immunology
MH  - Melanoma, Experimental/*immunology/pathology
MH  - Mice
MH  - Nanoparticles/*chemistry
MH  - Particle Size
MH  - Porosity
MH  - Silicon Dioxide/*chemistry
MH  - Surface Properties
MH  - T-Lymphocytes, Cytotoxic/immunology
OTO - NOTNLM
OT  - cancer immunotherapy
OT  - cytotoxic T cells
OT  - dendritic cells
OT  - hollow silica nanoparticles
OT  - mesoporous silica nanoparticles
EDAT- 2020/07/15 06:00
MHDA- 2021/02/17 06:00
CRDT- 2020/07/15 06:00
PHST- 2020/07/15 06:00 [pubmed]
PHST- 2021/02/17 06:00 [medline]
PHST- 2020/07/15 06:00 [entrez]
AID - 10.1021/acsami.0c09484 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2020 Aug 5;12(31):34658-34666. doi: 
      10.1021/acsami.0c09484. Epub 2020 Jul 28.