PMID- 32662704
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20220531
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 48
IP  - 7
DP  - 2020 Jul
TI  - Non-linear relationship between gamma-glutamyl transferase and type 2 diabetes 
      mellitus risk: secondary analysis of a prospective cohort study.
PG  - 300060520937911
LID - 10.1177/0300060520937911 [doi]
LID - 0300060520937911
AB  - OBJECTIVE: To investigate the association between gamma-glutamyl transferase 
      (GGT) and type 2 diabetes mellitus (T2DM) risk. METHODS: This was a secondary 
      analysis based on a publicly available DRYAD dataset that included 15 444 study 
      participants that received medical examinations at a single centre in Japan 
      between 2004 and 2015. Crude, minimally-adjusted and fully-adjusted regression 
      models were used to evaluate the relationship between GGT levels and T2DM risk. 
      RESULTS: The study participants (mean +/- SD age of 43.72 +/- 8.90 years; 8415 of 
      15 444 [54.49%] were male) were followed-up for a median of 1968 days (5.39 
      years). After adjusting for potential covariates, a non-linear relationship 
      between the baseline GGT level and T2DM incidence was observed. The inflection 
      point for T2DM risk was 10 IU/l GGT; below this point, the T2DM incidence 
      increased by 1.18-fold per unit change in GGT. Above this point, the association 
      between GGT and the incidence rate of T2DM became nonsignificant. CONCLUSION: 
      Baseline GGT exhibited a non-linear association with T2DM incidence. Elevated GGT 
      levels should be incorporated into routine screening for individuals at high risk 
      of T2DM, allowing for early intervention targeting GGT to potentially reduce 
      T2DM-related morbidity.
FAU - Wang, Hao
AU  - Wang H
AD  - Department of Cardiology, Luoyang Central Hospital Affiliated to Zhengzhou 
      University, Luoyang, Henan Province, China.
FAU - Li, Lixia
AU  - Li L
AUID- ORCID: 0000-0002-7382-2190
AD  - Department of Cardiology, Luoyang Central Hospital Affiliated to Zhengzhou 
      University, Luoyang, Henan Province, China.
FAU - Zhang, Shouyan
AU  - Zhang S
AUID- ORCID: 0000-0003-2902-1668
AD  - Department of Cardiology, Luoyang Central Hospital Affiliated to Zhengzhou 
      University, Luoyang, Henan Province, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
RN  - EC 2.3.2.2 (gamma-glutamyltransferase, human)
SB  - IM
MH  - Adult
MH  - *Diabetes Mellitus, Type 2/diagnosis/epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
MH  - *gamma-Glutamyltransferase
PMC - PMC7361500
OTO - NOTNLM
OT  - Gamma-glutamyl transferase
OT  - non-linearity
OT  - type 2 diabetes mellitus
EDAT- 2020/07/15 06:00
MHDA- 2021/05/15 06:00
PMCR- 2020/07/14
CRDT- 2020/07/15 06:00
PHST- 2020/07/15 06:00 [entrez]
PHST- 2020/07/15 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/07/14 00:00 [pmc-release]
AID - 10.1177_0300060520937911 [pii]
AID - 10.1177/0300060520937911 [doi]
PST - ppublish
SO  - J Int Med Res. 2020 Jul;48(7):300060520937911. doi: 10.1177/0300060520937911.