PMID- 32664413
OWN - NLM
STAT- MEDLINE
DCOM- 20210217
LR  - 20210217
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 14
DP  - 2020 Jul 10
TI  - Genetic Markers for Later Remission in Response to Early Improvement of 
      Antidepressants.
LID - 10.3390/ijms21144884 [doi]
LID - 4884
AB  - Planning subsequent treatment strategies based on early responses rather than 
      waiting for delayed antidepressant action can be helpful. We identified genetic 
      markers for later non-remission in patients exhibiting poor early improvement 
      using whole-exome sequencing data of depressive patients treated in a 
      naturalistic manner. Among 1000 patients, early improvement at 2 weeks (reduction 
      in Hamilton Depression Rating Scale [HAM-D] score >/= 20%) and remission at 12 
      weeks (HAM-D score </= 7) were evaluated. Gene- and variant-level analyses were 
      conducted to compare patients who did not exhibit early improvement and did not 
      eventually achieve remission (n = 126) with those who exhibited early improvement 
      and achieved remission (n = 385). Genes predicting final non-remission in 
      patients who exhibited poor early improvement (COMT, PRNP, BRPF3, SLC25A40, and 
      CGREF1 in males; PPFIBPI, LZTS3, MEPCE, MAP1A, and PFAS in females; ST3GAL5 in 
      the total population) were determined. Among the significant genes, variants in 
      the PRNP (rs1800014), COMT (rs6267), BRPF3 (rs200565609), and SLC25A40 genes 
      (rs3213633) were identified. However, interpretations should be made cautiously, 
      as complex pharmacotherapy involves various genes and pathways. Early detection 
      of poor early improvement and final non-remission based on genetic risk would be 
      helpful for decision-making in a clinical setting.
FAU - Kang, Hee-Ju
AU  - Kang HJ
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju 
      61469, Korea.
FAU - Kim, Ki-Tae
AU  - Kim KT
AD  - Department of Laboratory Medicine, Korea University Anam Hospital, Seoul 02841, 
      Korea.
FAU - Yoo, Kyung-Hun
AU  - Yoo KH
AD  - Seoul National University Biomedical Informatics (SNUBI), Division of Biomedical 
      Informatics, Seoul National University College of Medicine, Seoul 151-742, Korea.
FAU - Park, Yoomi
AU  - Park Y
AD  - Seoul National University Biomedical Informatics (SNUBI), Division of Biomedical 
      Informatics, Seoul National University College of Medicine, Seoul 151-742, Korea.
FAU - Kim, Ju-Wan
AU  - Kim JW
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju 
      61469, Korea.
FAU - Kim, Sung-Wan
AU  - Kim SW
AUID- ORCID: 0000-0002-6739-2163
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju 
      61469, Korea.
FAU - Shin, Il-Seon
AU  - Shin IS
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju 
      61469, Korea.
FAU - Kim, Ju Han
AU  - Kim JH
AD  - Seoul National University Biomedical Informatics (SNUBI), Division of Biomedical 
      Informatics, Seoul National University College of Medicine, Seoul 151-742, Korea.
FAU - Kim, Jae-Min
AU  - Kim JM
AUID- ORCID: 0000-0001-7409-6306
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju 
      61469, Korea.
LA  - eng
GR  - NRF-2019M3C7A1031345/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20200710
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Antidepressive Agents)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Antidepressive Agents/*therapeutic use
MH  - Depressive Disorder, Major/*drug therapy/*genetics
MH  - Female
MH  - Genetic Markers/*genetics
MH  - Genetic Variation/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Remission Induction/methods
MH  - Signal Transduction/genetics
MH  - Treatment Outcome
PMC - PMC7402334
OTO - NOTNLM
OT  - antidepressant
OT  - genetic marker
OT  - improvement
OT  - remission
OT  - treatment outcome
OT  - whole-exome sequencing
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2020/07/16 06:00
MHDA- 2021/02/18 06:00
PMCR- 2020/07/01
CRDT- 2020/07/16 06:00
PHST- 2020/06/01 00:00 [received]
PHST- 2020/07/01 00:00 [revised]
PHST- 2020/07/08 00:00 [accepted]
PHST- 2020/07/16 06:00 [entrez]
PHST- 2020/07/16 06:00 [pubmed]
PHST- 2021/02/18 06:00 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - ijms21144884 [pii]
AID - ijms-21-04884 [pii]
AID - 10.3390/ijms21144884 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Jul 10;21(14):4884. doi: 10.3390/ijms21144884.