PMID- 32664812
OWN - NLM
STAT- MEDLINE
DCOM- 20210422
LR  - 20210422
IS  - 2058-7384 (Electronic)
IS  - 0394-6320 (Print)
IS  - 0394-6320 (Linking)
VI  - 34
DP  - 2020 Jan-Dec
TI  - Primary central nervous system ALK-positive anaplastic large cell lymphoma with 
      CD56 abnormally expression in a Chinese child: Challenge in diagnostic practice.
PG  - 2058738420941756
LID - 10.1177/2058738420941756 [doi]
LID - 2058738420941756
AB  - Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma 
      (ALK + ALCL) is most frequent in youth and possesses a broad morphologic 
      spectrum. However, involvement in central nervous system (CNS) is definitely 
      rare. The case we presented was a 12-year-old Chinese male who presented with 
      headache and emesis for a couple of days. The neoplastic component was smaller 
      cells resembling starry-sky growth pattern and immunohistochemical stained 
      positively for CD30, ALK1, and CD56. Monoclonal T-cell receptor (TCRgamma) gene 
      rearrangement and gene translocation involving ALK identified by fluorescence in 
      situ hybridization (FISH) using ALK break apart probe supported the diagnosis of 
      ALK + ALCL. This case showed ALK + ALCL occur in a rare site with an abnormal 
      CD56 expression. Awareness of this entity is important to distinguish it from 
      other intracranial lymphoma.
FAU - Liu, Qian
AU  - Liu Q
AD  - Department of Pathology, Jiangxi Provincial People's Hospital Affiliated to 
      Nanchang University, Nanchang, China.
AD  - Department of Pathology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Chen, Xian
AU  - Chen X
AD  - Department of Pathology, Hospital of Chengdu University of Traditional Chinese 
      Medicine, Chengdu, China.
FAU - Li, Gandi
AU  - Li G
AD  - Department of Pathology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Ye, Yunxia
AU  - Ye Y
AD  - Department of Pathology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Liu, Weiping
AU  - Liu W
AD  - Department of Pathology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Zhao, Sha
AU  - Zhao S
AD  - Department of Pathology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Zhang, Wenyan
AU  - Zhang W
AUID- ORCID: 0000-0002-0760-2763
AD  - Department of Pathology, West China Hospital of Sichuan University, Chengdu, 
      China.
LA  - eng
PT  - Case Reports
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CD56 Antigen)
RN  - 0 (Ki-1 Antigen)
RN  - 0 (NCAM1 protein, human)
RN  - EC 2.7.10.1 (ALK protein, human)
RN  - EC 2.7.10.1 (Anaplastic Lymphoma Kinase)
SB  - IM
MH  - Anaplastic Lymphoma Kinase/*genetics
MH  - *Biomarkers, Tumor/analysis/genetics
MH  - Brain Neoplasms/*genetics/*immunology
MH  - CD56 Antigen/*analysis
MH  - Child
MH  - Fatal Outcome
MH  - Gene Rearrangement
MH  - Genes, T-Cell Receptor gamma
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Ki-1 Antigen/analysis
MH  - Lymphoma, Large-Cell, Anaplastic/*genetics/*immunology
MH  - Male
MH  - Translocation, Genetic
PMC - PMC7364798
OTO - NOTNLM
OT  - ALK + anaplastic large cell lymphoma (ALK + ALCL)
OT  - CD56
OT  - central nervous system (CNS)
COIS- Declaration of conflicting interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2020/07/16 06:00
MHDA- 2021/04/23 06:00
PMCR- 2020/07/15
CRDT- 2020/07/16 06:00
PHST- 2020/07/16 06:00 [entrez]
PHST- 2020/07/16 06:00 [pubmed]
PHST- 2021/04/23 06:00 [medline]
PHST- 2020/07/15 00:00 [pmc-release]
AID - 10.1177_2058738420941756 [pii]
AID - 10.1177/2058738420941756 [doi]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2020 Jan-Dec;34:2058738420941756. doi: 
      10.1177/2058738420941756.