PMID- 32664843
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220405
IS  - 2772-4336 (Electronic)
IS  - 2772-4328 (Linking)
VI  - 16
IP  - 3
DP  - 2021
TI  - Corticosteroids in Inflammatory Bowel Disease Patients: A Practical Guide for 
      Physicians.
PG  - 210-218
LID - 10.2174/1574884715666200714114044 [doi]
AB  - Inflammatory Bowel Diseases (IBDs) are chronic conditions characterized by 
      unknown etiology and pathogenesis with deregulation of mucosal immunity. Among 
      possible treatments, corticosteroids, already available from the '50s, are still 
      the mainstay of treatment for moderate to severe disease. Nonetheless, the use of 
      steroids is still largely empirical and solid evidence about therapeutic schemes 
      are lacking. Moreover, due to the important side-effects and for the 
      unsatisfactory impact on the long-term natural history of the disease, the 
      steroid-sparing has become an important therapeutic goal in IBD management. 
      Besides conventional steroids, the so-called "low bioavailability" steroids, 
      which are steroids with high affinity for peripheral receptors and elevated 
      hepatic first-pass metabolism, have demonstrated efficacy and a more favorable 
      safety profile. In the present review of the literature evidence of efficacy and 
      safety of conventional and low bioavailability steroids in IBD patients are 
      evaluated, and practical suggestions for a correct use in clinical practice are 
      presented according to the current clinical guidelines.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Di Paolo, Maria Carla
AU  - Di Paolo MC
AD  - Department of Gastroenterology and Digestive Endoscopy, S. Giovanni Addolorata 
      Hospital, Via dell' Amba Aradam 9, 00184 Rome, Italy.
FAU - Pagnini, Cristiano
AU  - Pagnini C
AD  - Department of Gastroenterology and Digestive Endoscopy, S. Giovanni Addolorata 
      Hospital, Via dell' Amba Aradam 9, 00184 Rome, Italy.
FAU - Graziani, Maria Giovanna
AU  - Graziani MG
AD  - Department of Gastroenterology and Digestive Endoscopy, S. Giovanni Addolorata 
      Hospital, Via dell' Amba Aradam 9, 00184 Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Curr Rev Clin Exp Pharmacol
JT  - Current reviews in clinical and experimental pharmacology
JID - 9918227368306676
RN  - 0 (Adrenal Cortex Hormones)
SB  - IM
MH  - Adrenal Cortex Hormones/adverse effects
MH  - Chronic Disease
MH  - *Colitis
MH  - Humans
MH  - *Inflammatory Bowel Diseases/drug therapy
MH  - *Physicians
OTO - NOTNLM
OT  - Inflammatory bowel disease
OT  - corticosteroids
OT  - crohn's disease
OT  - low bioavailability steroids.
OT  - peripheral receptors
OT  - ulcerative colitis
EDAT- 2020/07/16 06:00
MHDA- 2022/04/05 06:00
CRDT- 2020/07/16 06:00
PHST- 2020/02/07 00:00 [received]
PHST- 2020/05/19 00:00 [revised]
PHST- 2020/06/10 00:00 [accepted]
PHST- 2020/07/16 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2020/07/16 06:00 [entrez]
AID - CCP-EPUB-108164 [pii]
AID - 10.2174/1574884715666200714114044 [doi]
PST - ppublish
SO  - Curr Rev Clin Exp Pharmacol. 2021;16(3):210-218. doi: 
      10.2174/1574884715666200714114044.