PMID- 3266525
OWN - NLM
STAT- MEDLINE
DCOM- 19890516
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 94
IP  - 1-2
DP  - 1988 Nov 22
TI  - Food intake suppression by growth factors and platelet peptides by direct action 
      in the central nervous system.
PG  - 161-6
AB  - Intracerebroventricular (i.c.v.) microinfusion of epidermal growth factor (EGF), 
      basic fibroblast growth factor (bFGF) and platelet factor 4 (PF4) suppressed 2 h 
      and nighttime food intake in rats. The following daytime food intake did not 
      change or increased. I.c.v. infusion of platelet-derived growth factor (PDGF) 
      suppressed only 2 h food intake. I.c.v. infusion of bovine serum albumin (BSA), 
      nerve growth factor (NGF), or inactivated EGF, bFGF and PF4 had no effect. 
      Intraperitoneal (i.p.) administration of EGF, bFGF, PF4 and PDGF in doses 
      equivalent to or higher than those administered centrally had no effect. The 
      results suggest a central action of growth factors and platelet peptides on 
      feeding regulation.
FAU - Plata-Salaman, C R
AU  - Plata-Salaman CR
AD  - Department of Psychology and Institute for Neuroscience, University of Delaware, 
      Newark 19716.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 37270-94-3 (Platelet Factor 4)
RN  - 62031-54-3 (Fibroblast Growth Factors)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
MH  - Animals
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - Epidermal Growth Factor/administration & dosage/*pharmacology
MH  - Feeding Behavior/*drug effects
MH  - Fibroblast Growth Factors/administration & dosage/*pharmacology
MH  - Infusions, Parenteral
MH  - Male
MH  - Platelet Factor 4/administration & dosage/*pharmacology
MH  - Platelet-Derived Growth Factor/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reference Values
EDAT- 1988/11/22 00:00
MHDA- 1988/11/22 00:01
CRDT- 1988/11/22 00:00
PHST- 1988/11/22 00:00 [pubmed]
PHST- 1988/11/22 00:01 [medline]
PHST- 1988/11/22 00:00 [entrez]
AID - 0304-3940(88)90288-1 [pii]
AID - 10.1016/0304-3940(88)90288-1 [doi]
PST - ppublish
SO  - Neurosci Lett. 1988 Nov 22;94(1-2):161-6. doi: 10.1016/0304-3940(88)90288-1.