PMID- 32666169
OWN - NLM
STAT- MEDLINE
DCOM- 20201102
LR  - 20201102
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 36
IP  - 11
DP  - 2020 Nov
TI  - Diffusion-weighted imaging in hypertrophic cardiomyopathy: association with high 
      T2-weighted signal intensity in addition to late gadolinium enhancement.
PG  - 2229-2238
LID - 10.1007/s10554-020-01933-2 [doi]
AB  - Diffusion-weighted imaging (DWI) has been confirmed to be associated with late 
      gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM). In this 
      context, we aimed to study whether DWI could reflect the active tissue injury and 
      edema information of HCM which were usually indicated by T2 weighted images. 
      Forty HCM patients were examined using a 3.0 T magnetic resonance scanner. Cine, 
      T2-weighted short tau inversion recovery (T2-STIR), DWI and LGE sequences were 
      acquired. T1 mapping was also included to quantify the focal and diffuse 
      fibrosis. Cardiac troponin I (cTnI) was tested to assess the recently myocardial 
      injury. Student's t-test, Mann-Whitney U test, One-way analysis, Kruskal-Wallis 
      analysis, the Spearman correlation analysis, and multivariable regression were 
      used in this study. The apparent diffusion coefficient (ADC) was significantly 
      elevated in the cTnI positive group (P = 0.01) and correlated with LGE 
      (rho = 0.312, P = 0.049) and HighT2 extent (rho = 0.443, P = 0.004) in the global 
      level. In the segmental analysis, the ADC significantly differentiated the 
      segments with and without HighT2/LGE presence (P = 0.00). The average ADC values 
      were higher in segments with HighT2 and LGE coexistence than in those with only 
      LGE presence (P < 0.05). Multivariable regression indicated that segmental HighT2 
      and LGE were both contributing factors to the ADC values. In this study of HCM, 
      we confirmed that ADC as a molecular diffusion parameter reflects the replacement 
      fibrosis of myocardium. Moreover, it also reveals edema extent and its 
      association with serum cTnI.
FAU - Shi, Ruo-Yang
AU  - Shi RY
AD  - Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, No. 160, Pujian Road, Shanghai, 200127, China.
FAU - An, Dong-Aolei
AU  - An DA
AD  - Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, No. 160, Pujian Road, Shanghai, 200127, China.
FAU - Chen, Bing-Hua
AU  - Chen BH
AD  - Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, No. 160, Pujian Road, Shanghai, 200127, China.
FAU - Wu, Rui
AU  - Wu R
AD  - Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, No. 160, Pujian Road, Shanghai, 200127, China.
FAU - Du, Liang
AU  - Du L
AD  - Robotics Institute, Shanghai Jiao Tong University, Shanghai, China.
FAU - Jiang, Meng
AU  - Jiang M
AD  - Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Xu, Jian-Rong
AU  - Xu JR
AD  - Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, No. 160, Pujian Road, Shanghai, 200127, China. xujrrj@163.com.
FAU - Wu, Lian-Ming
AU  - Wu LM
AD  - Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, No. 160, Pujian Road, Shanghai, 200127, China. wlmssmu@126.com.
LA  - eng
GR  - 81873886/National Natural Science Foundation of China/
GR  - 81873887/National Natural Science Foundation of China/
GR  - 2017YQ031/Shanghai Municipal Commission of Health and Family Planning excellent 
      young talent program/
GR  - YG2017QN44/Shanghai Jiao Tong University medical cross project/
GR  - SHDC12018X21/Shanghai Shenkang Hospital Development Center Clinical Research and 
      Cultivation Project/
GR  - 19DZ2203800/Shanghai Science and technology innovation action plan, technology 
      standard project Grant numbers/
PT  - Comparative Study
PT  - Journal Article
DEP - 20200714
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Biomarkers)
RN  - 0 (Contrast Media)
RN  - 0 (Troponin I)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Cardiomyopathy, Hypertrophic/blood/*diagnostic imaging/pathology
MH  - Contrast Media/*administration & dosage
MH  - *Diffusion Magnetic Resonance Imaging
MH  - Edema, Cardiac/blood/*diagnostic imaging/pathology
MH  - Female
MH  - Fibrosis
MH  - Gadolinium DTPA/*administration & dosage
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardium/metabolism/*pathology
MH  - Predictive Value of Tests
MH  - Troponin I/blood
OTO - NOTNLM
OT  - Cardiac troponin I
OT  - Diffusion weighted imaging
OT  - High signal intensity on T2-weighted imaging
OT  - Hypertrophic cardiomyopathy
EDAT- 2020/07/16 06:00
MHDA- 2020/11/03 06:00
CRDT- 2020/07/16 06:00
PHST- 2020/05/08 00:00 [received]
PHST- 2020/07/03 00:00 [accepted]
PHST- 2020/07/16 06:00 [pubmed]
PHST- 2020/11/03 06:00 [medline]
PHST- 2020/07/16 06:00 [entrez]
AID - 10.1007/s10554-020-01933-2 [pii]
AID - 10.1007/s10554-020-01933-2 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2020 Nov;36(11):2229-2238. doi: 
      10.1007/s10554-020-01933-2. Epub 2020 Jul 14.