PMID- 32666252
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20210818
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 258
IP  - 11
DP  - 2020 Nov
TI  - Choriocapillaris flow deficit associated with intraretinal hyperreflective foci 
      in intermediate age-related macular degeneration.
PG  - 2353-2362
LID - 10.1007/s00417-020-04837-y [doi]
AB  - PURPOSE: To evaluate the choriocapillaris (CC) flow deficit (FD) beneath drusen 
      associated with overlying intraretinal hyperreflective foci (HRF). METHODS: 
      Patients with intermediate age-related macular degeneration (AMD) who had 
      structural spectral-domain optical coherence tomography (SD-OCT) and OCT 
      angiography (OCTA) using the Cirrus HD-OCT with AngioPlex software were 
      retrospectively evaluated. A 6 x 6-mm-volume scan was used for the SD-OCT and 
      OCTA. Post-imaging processing steps included generation of drusen map, 
      identification of HRF, and generation of a signal-compensated CC slab prior to 
      binarization and CC FD computation. The CC OCTA image was aligned with the drusen 
      + HRF map to define regions of interest for CC FD measurement. The CC was 
      quantified below drusen with and without overlying HRF and within a 150-mum-wide 
      ring surrounding the drusen (unaffected by potential HRF-related shadowing), and 
      across the entire 6 x 6 macular region. RESULTS: Fifty-three eyes with 
      intermediate AMD were included, 25 eyes with HRF, and 28 eyes with no HRF. The 
      mean +/- SD FD% over the whole 6 x 6 macular region was 41.1 +/- 3.4 in eyes with HRF 
      compared with 39.5 +/- 3.5 in eyes without HRF (p = 0.001). The mean +/- SD CC FD% 
      below drusen with HRF (54.4 +/- 9.3) was significantly greater than below drusen 
      without HRF (49.6 +/- 9.5; p = 0.001). There was a strong positive correlation 
      between the quantity of HRF and the extent of the CC FD (Pearson 
      correlation = 0.81). CONCLUSION: Choriocapillaris flow deficits appear to be more 
      severe in eyes with HRF and in particular directly below HRF. As HRF are thought 
      to represent a higher risk or more advanced feature of intermediate AMD, these 
      findings highlight the relationship between the severity of CC FD and overall 
      severity of AMD.
FAU - Tiosano, Liran
AU  - Tiosano L
AD  - Doheny Image Reading and Research Lab, Doheny Eye Institute, 1355 San Pablo 
      Street, Suite 211, Los Angeles, CA, 90033, USA.
AD  - Department of Ophthalmology, David Geffen School of Medicine, UCLA, Los Angeles, 
      CA, USA.
AD  - Department of Ophthalmology, Hadassah-Hebrew University Medical Center, and the 
      Hebrew University - Hadassah School of Medicine, Jerusalem, Israel.
FAU - Byon, Iksoo
AU  - Byon I
AD  - Doheny Image Reading and Research Lab, Doheny Eye Institute, 1355 San Pablo 
      Street, Suite 211, Los Angeles, CA, 90033, USA.
AD  - Department of Ophthalmology, David Geffen School of Medicine, UCLA, Los Angeles, 
      CA, USA.
AD  - Department of Ophthalmology, Research Institute for Convergence of Biomedical 
      Science and Technology, Pusan National University Yangsan Hospital, Pusan 
      National University School of Medicine, Yangsan, South Korea.
FAU - Alagorie, Ahmed Roshdy
AU  - Alagorie AR
AD  - Doheny Image Reading and Research Lab, Doheny Eye Institute, 1355 San Pablo 
      Street, Suite 211, Los Angeles, CA, 90033, USA.
AD  - Department of Ophthalmology, David Geffen School of Medicine, UCLA, Los Angeles, 
      CA, USA.
AD  - Department of Ophthalmology, Faculty of Medicine, Tanta University, Tanta, Egypt.
FAU - Ji, Yong-Sok
AU  - Ji YS
AD  - Doheny Image Reading and Research Lab, Doheny Eye Institute, 1355 San Pablo 
      Street, Suite 211, Los Angeles, CA, 90033, USA.
AD  - Department of Ophthalmology, David Geffen School of Medicine, UCLA, Los Angeles, 
      CA, USA.
AD  - Department of Ophthalmology, Chonnam National University Medical School and 
      Hospital, Gwangju, South Korea.
FAU - Sadda, Srinivas R
AU  - Sadda SR
AUID- ORCID: 0000-0002-4939-3306
AD  - Doheny Image Reading and Research Lab, Doheny Eye Institute, 1355 San Pablo 
      Street, Suite 211, Los Angeles, CA, 90033, USA. Sadda@doheny.org.
AD  - Department of Ophthalmology, David Geffen School of Medicine, UCLA, Los Angeles, 
      CA, USA. Sadda@doheny.org.
LA  - eng
PT  - Journal Article
DEP - 20200715
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Choroid
MH  - Fluorescein Angiography
MH  - Humans
MH  - *Macular Degeneration/diagnosis
MH  - *Retinal Drusen/diagnosis
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
OTO - NOTNLM
OT  - Age-related macular degeneration
OT  - Choriocapillaris flow deficit
OT  - Hyperreflective foci
EDAT- 2020/07/16 06:00
MHDA- 2021/08/19 06:00
CRDT- 2020/07/16 06:00
PHST- 2019/12/13 00:00 [received]
PHST- 2020/07/08 00:00 [accepted]
PHST- 2020/06/19 00:00 [revised]
PHST- 2020/07/16 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2020/07/16 06:00 [entrez]
AID - 10.1007/s00417-020-04837-y [pii]
AID - 10.1007/s00417-020-04837-y [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2020 Nov;258(11):2353-2362. doi: 
      10.1007/s00417-020-04837-y. Epub 2020 Jul 15.