PMID- 32668273
OWN - NLM
STAT- MEDLINE
DCOM- 20210128
LR  - 20211002
IS  - 1873-5894 (Electronic)
IS  - 0730-725X (Print)
IS  - 0730-725X (Linking)
VI  - 72
DP  - 2020 Oct
TI  - Noninvasive assessment of abdominal adipose tissues and quantification of hepatic 
      and pancreatic fat fractions in type 2 diabetes mellitus.
PG  - 95-102
LID - S0730-725X(20)30326-X [pii]
LID - 10.1016/j.mri.2020.07.001 [doi]
AB  - The purpose of this study was to evaluate adipose tissue distributions and 
      hepatic and pancreatic fat contents using a 6-point Dixon MRI technique in type 2 
      diabetes mellitus (T2DM), and to assess associations between fat distributions 
      and biochemical markers of insulin resistance. Intra-abdominal MRI was 
      investigated in 14 T2DM patients, 13 age- and sex-matched healthy controls (HC) 
      and 11 young HC using a 3 T Prisma MRI scanner. All T2DM subjects completed a 
      fasting comprehensive metabolic panel, and demographic measurements were taken 
      according to standardized methodologies. We observed excellent correlation 
      (R(2) = 0.94) between hepatic fat fraction quantified using 6-point Dixon MRI and 
      gold standard MRS, establishing the accuracy and reliability of the Dixon 
      technique. Significantly increased visceral adipose tissue (VAT) volumes were 
      found in T2DM patients compared to age-matched HC (1569.81 +/- 670.62 cm(3) vs. 
      1106.60 +/- 566.85 cm(3), p = .04). We also observed a trend of increasing 
      subcutaneous adipose tissues (SAT), and total abdominal fat (TAT) volumes in T2DM 
      compared to age-matched HC. Hepatic fat fraction percentage (HFF%) was 44.6% 
      higher in T2DM compared to age-matched HC and 64.4% higher compared to young HC. 
      Pancreatic fat fractions in the head and body/tail were higher in T2DM patients 
      compared to both healthy cohorts. We also observed correlations between fat 
      contents of the liver and pancreas in T2DM patients, and association between 
      biochemical markers of T2DM with HFF, indicating a risk for non-alcoholic fatty 
      liver disease among T2DM. In summary, this study provides evidence of T2DM 
      patients having increased liver and pancreatic fat, as well as increased adipose 
      tissues.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Sarma, Manoj Kumar
AU  - Sarma MK
AD  - Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, 
      United States of America. Electronic address: msarma@mednet.ucla.edu.
FAU - Saucedo, Andres
AU  - Saucedo A
AD  - Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, 
      United States of America. Electronic address: asaucedo@mednet.ucla.edu.
FAU - Darwin, Christine Hema
AU  - Darwin CH
AD  - Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States 
      of America. Electronic address: cdarwin@mednet.ucla.edu.
FAU - Felker, Ely Richard
AU  - Felker ER
AD  - Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, 
      United States of America. Electronic address: efelker@mednet.ucla.edu.
FAU - Umachandran, Kavya
AU  - Umachandran K
AD  - Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, 
      United States of America. Electronic address: kavyauma@ucla.edu.
FAU - Kohanghadosh, Daniel
AU  - Kohanghadosh D
AD  - Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, 
      United States of America.
FAU - Xu, Edward
AU  - Xu E
AD  - Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, 
      United States of America.
FAU - Raman, Steve
AU  - Raman S
AD  - Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, 
      United States of America. Electronic address: sraman@mednet.ucla.edu.
FAU - Thomas, Michael Albert
AU  - Thomas MA
AD  - Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, 
      United States of America. Electronic address: athomas@mednet.ucla.edu.
LA  - eng
GR  - R21 EB020883/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20200712
PL  - Netherlands
TA  - Magn Reson Imaging
JT  - Magnetic resonance imaging
JID - 8214883
SB  - IM
MH  - Abdominal Fat/diagnostic imaging/*pathology
MH  - Adult
MH  - Diabetes Mellitus, Type 2/diagnostic imaging/*pathology
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Liver/*pathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Pancreas/*pathology
MH  - Reproducibility of Results
PMC - PMC7442732
MID - NIHMS1613312
OTO - NOTNLM
OT  - Abdominal fat
OT  - Adipose tissue
OT  - Dixon
OT  - Hepatic fat fraction
OT  - MRI
OT  - T2DM
EDAT- 2020/07/16 06:00
MHDA- 2021/01/29 06:00
PMCR- 2021/10/01
CRDT- 2020/07/16 06:00
PHST- 2020/05/13 00:00 [received]
PHST- 2020/07/01 00:00 [revised]
PHST- 2020/07/01 00:00 [accepted]
PHST- 2020/07/16 06:00 [pubmed]
PHST- 2021/01/29 06:00 [medline]
PHST- 2020/07/16 06:00 [entrez]
PHST- 2021/10/01 00:00 [pmc-release]
AID - S0730-725X(20)30326-X [pii]
AID - 10.1016/j.mri.2020.07.001 [doi]
PST - ppublish
SO  - Magn Reson Imaging. 2020 Oct;72:95-102. doi: 10.1016/j.mri.2020.07.001. Epub 2020 
      Jul 12.